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981.
Claudie Laprise Sreenath A. Madathil Paul Allison Priya Abraham Anantharam Raghavendran Hameed P. Shahul Akhil‐Soman ThekkePurakkal Geneviève Castonguay François Coutlée Nicolas F. Schlecht Marie‐Claude Rousseau Eduardo L. Franco Belinda Nicolau 《International journal of cancer. Journal international du cancer》2016,138(4):912-917
Oral cancer is a major public health issue in India with ~77,000 new cases and 52,000 deaths yearly. Paan chewing, tobacco and alcohol use are strong risk factors for this cancer in India. Human papillomaviruses (HPVs) are also related to a subset of head and neck cancers (HNCs). We examined the association between oral HPV and oral cancer in a sample of Indian subjects participating in a hospital‐based case‐control study. We recruited incident oral cancer cases (N = 350) and controls frequency‐matched by age and sex (N = 371) from two main referral hospitals in Kerala, South India. Sociodemographic and behavioral data were collected by interviews. Epithelial cells were sampled using Oral CDx® brushes from the oral cancer site and the normal mucosa. Detection and genotyping of 36 HPV genotypes were done using a polymerase chain reaction protocol. Data collection procedures were performed by qualified dentists via a detailed protocol with strict quality control, including independent HPV testing in India and Canada. HPV DNA was detected in none of the cases or controls. Associations between oral cancer and risk factors usually associated with HPV infection, such as oral sex and number of lifetime sexual partners, were examined by logistic regression and were not associated with oral cancer. Lack of a role for HPV infection in this study may reflect cultural or religious characteristics specific to this region in India that are not conducive to oral HPV transmission. A nationwide representative prevalence study is needed to investigate HPV prevalence variability among Indian regions. 相似文献
982.
Alexandre Tang Gilles Dadaglio Marine Oberkampf Selene Di Carlo Lucie Peduto Daphné Laubreton Belinda Desrues Cheng‐Ming Sun Xavier Montagutelli Claude Leclerc 《International journal of cancer. Journal international du cancer》2016,139(6):1358-1371
Enhancing anti‐tumor immunity and preventing tumor escape are efficient strategies to increase the efficacy of therapeutic cancer vaccines. However, the treatment of advanced tumors remains difficult, mainly due to the immunosuppressive tumor microenvironment. Regulatory T cells and myeloid‐derived suppressor cells have been extensively studied, and their role in suppressing tumor immunity is now well established. In contrast, the role of B lymphocytes in tumor immunity remains unclear because B cells can promote tumor immunity or display regulatory functions to control excessive inflammation, mainly through IL‐10 secretion. Here, in a mouse model of HPV‐related cancer, we demonstrate that B cells accumulated in the draining lymph node of tumor‐bearing mice, due to a prolonged survival, and showed a decreased expression of MHC class II and CD86 molecules and an increased expression of Ly6A/E, PD‐L1 and CD39, suggesting potential immunoregulatory properties. However, B cells from tumor‐bearing mice did not show an increased ability to secrete IL‐10 and a deficiency in IL‐10 production did not impair tumor growth. In contrast, in B cell‐deficient μMT mice, tumor rejection occurred due to a strong T cell‐dependent anti‐tumor response. Genetic analysis based on single nucleotide polymorphisms identified genetic variants associated with tumor rejection in μMT mice, which could potentially affect reactive oxygen species production and NK cell activity. Our results demonstrate that B cells play a detrimental role in anti‐tumor immunity and suggest that targeting B cells could enhance the anti‐tumor response and improve the efficacy of therapeutic cancer vaccines. 相似文献
983.
Nicolau B Marcenes W Allison P Sheiham A 《Community dentistry and oral epidemiology》2005,33(2):93-98
AIM: To investigate the relationship between height and dental caries in Brazilian adolescents. METHODS: A cross-sectional survey design was used to collect retrospective data. Of 764 eligible 13-year-old adolescents enrolled in urban private or public schools in a Brazilian town, 652 were clinically examined and interviewed. Data were collected on socioeconomic circumstances, family related variables, oral health behaviour and anthropometric measures (height and weight). Dental caries was measured by decayed, missing and filled teeth (DMFT) index. The DMFT was categorized according to two levels of severity (low DMFT = 6; high DMFT > 6) using the 75th percentile of the distribution as the cut-off point. Data analysis involved multiple logistic regression. RESULTS: Adolescents who were the second or later child were 1.90 times more likely to have a high DMFT, whilst being a taller adolescent had a protective effect on caries experience (OR = 0.04; 95% CI = 0.00-0.79). In addition, adolescents from rural areas (OR = 2.74; 95% CI = 1.56-4.82), those whose mothers had less than 8 years of education (OR = 2.10; 95% CI = 1.03-4.27) and those who reported high levels of paternal punishment (OR = 1.60; 95% CI = 1.02-2.52) had an increased risk of having a high DMFT. CONCLUSION: There is a relationship between height and dental caries experience in this sample of Brazilian adolescents. 相似文献
984.
Few models have been proposed to explain the aetiology of traumatic dental injuries. Those that have, focus on risk factors at present stage of life. The contribution of risk factors for dental injuries at different stages of life needs to be investigated. OBJECTIVES: To test the relationship between life course experiences and the occurrence of traumatic dental injuries in adolescents. METHODS: A cross-sectional survey was used to collect data retrospectively. Out of a total number of 764 eligible 13-year-old-adolescents enrolled in private and public schools located in urban areas in the town of Cianorte, Brazil, 652 (85%) agreed to participate in the study. They were interviewed and examined for traumatic dental injuries by two trained dental epidemiologists using validated criteria. The interviews collected information on socioeconomic circumstances, family related variables, school grade and anthropometric measures (height and weight). RESULTS: Adolescent boys, those from non-nuclear families, those reporting high levels of paternal punishment and those who were at lower grades at school for their age were more likely to experience dental injuries than girls, adolescents from nuclear families, those reporting low levels of paternal punishment and those who were at higher grades at school. CONCLUSION: It was concluded that adolescents who experienced adverse psychosocial environments along the life course had more traumatic dental injuries than their counterparts who experienced more favourable environments. 相似文献
985.
Shawna Grissom Jessika Boles Katherine Bailey Kathryn Cantrell Amy Kennedy April Sykes Belinda N. Mandrell 《Supportive care in cancer》2016,24(6):2421-2427
Purpose
The primary objective of this study was to examine the relationship between play-based procedural preparation and support intervention and use of sedation in children with central nervous system (CNS) tumors during radiation therapy. The secondary objective was to analyze the cost-effectiveness of the intervention compared to costs associated with daily sedation.Methods
A retrospective chart review was conducted, and 116 children aged 5–12 years met criteria for inclusion. Outcome measures included the total number of radiation treatments received, the number of treatments received with and without sedation, and the type and duration of interventions, which consisted of developmentally appropriate play, education, preparation, and distraction provided by a certified child life specialist.Results
The results of univariate analyses showed that age, tumor location, and total number and duration of interventions were significantly associated with sedation use during radiation therapy. Multivariate analyses showed that, after adjustment for age, tumor location, and craniospinal radiation, a significant relationship was found between the total number and duration of the interventions and sedation use. The implementation of a play-based procedural preparation and support intervention provided by a certified child life specialist significantly reduced health-care costs by decreasing the necessity of daily sedation.Conclusions
Support interventions provided by child life specialists significantly decreased both sedation use and the cost associated with daily sedation during cranial radiation therapy in children with CNS tumors. This study supports the value of the child life professional as a play-based developmental specialist and a crucial component of cost-effective healthcare.986.
987.
Profiling postprandial thermogenesis in muscle and fat of sheep and the central effect of leptin administration 总被引:2,自引:0,他引:2
Brown adipose tissue thermogenesis is an important component of energy expenditure as exemplified in rodents. Other tissues such as white adipose tissue and muscle are also capable of thermogenesis, but regulation of heat production in these tissues is poorly understood. We used a relatively large animal model, the ovariectomized sheep, in which site-specific temperature measurements were made as an index of thermogenic output. Dataloggers were implanted into the retroperitoneal (visceral) fat, gluteal (sc) fat, and skeletal muscle of the hind limb, and were programmed to record temperature every 15 min. Animals (n = 4) were then placed on a feeding schedule (fed between 1100 and 1600 h) to entrain a postprandial response in thermogenesis. Baseline thermogenesis (0800-1100 h) was higher (P < 0.05) in visceral fat and muscle than in gluteal fat, whereas the amplitude of the postprandial increase was similar at all three sites. Intracerebroventricular infusion into the lateral ventricle of either vehicle (artificial cerebrospinal fluid) or leptin (10 microg/h at 100 microl/h) for 24 h (0900-0900) was performed in a cross-over design with a 1-wk recovery period between treatments. Central leptin infusion did not alter the basal thermogenic rate but markedly enhanced the postprandial response in both fat and muscle tissues. This was manifest by increased (P < 0.05) amplitude and duration of the postprandial thermogenic response, and the effect was greater in muscle and visceral fat than in gluteal fat. These data demonstrate that leptin is able to regulate thermogenesis in muscle, providing a novel target for the manipulation of energy balance. 相似文献
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