全文获取类型
收费全文 | 247篇 |
免费 | 28篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 7篇 |
妇产科学 | 14篇 |
基础医学 | 30篇 |
口腔科学 | 22篇 |
临床医学 | 39篇 |
内科学 | 52篇 |
皮肤病学 | 8篇 |
神经病学 | 16篇 |
特种医学 | 10篇 |
外科学 | 18篇 |
综合类 | 3篇 |
现状与发展 | 1篇 |
预防医学 | 21篇 |
眼科学 | 1篇 |
药学 | 23篇 |
肿瘤学 | 8篇 |
出版年
2023年 | 4篇 |
2022年 | 12篇 |
2021年 | 14篇 |
2020年 | 20篇 |
2019年 | 26篇 |
2018年 | 23篇 |
2017年 | 13篇 |
2016年 | 10篇 |
2015年 | 18篇 |
2014年 | 13篇 |
2013年 | 13篇 |
2012年 | 16篇 |
2011年 | 24篇 |
2010年 | 9篇 |
2009年 | 7篇 |
2008年 | 5篇 |
2007年 | 12篇 |
2006年 | 8篇 |
2005年 | 6篇 |
2004年 | 4篇 |
2003年 | 2篇 |
2002年 | 5篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1994年 | 2篇 |
1992年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有276条查询结果,搜索用时 15 毫秒
61.
62.
Oktay Bilgir Belma Gökçen Ferda Bilgir Aslı Guler Mehmet Calan Arif Yuksel Behnaz Aslanıpour Murat Akşit Giray Bozkaya 《The American journal of the medical sciences》2018,355(1):37-43
Background
Growing evidence suggest that macrophage migration inhibitory factor (MIF) plays a vital role in glucose metabolism. We aimed to ascertain whether MIF levels are altered in subjects with prediabetes and also to determine the relationship between MIF and metabolic parameters as well as visceral fat mass.Material and Methods
This cross-sectional study included 40 subjects with prediabetes and 40 age-, body mass index (BMI)- and sex-matched subjects with normal glucose tolerance. Circulating MIF levels were measured using enzyme-linked immunosorbent assay. Metabolic parameters of recruited subjects were evaluated. Visceral fat mass was measured using bioelectrical impedance method.Results
Circulating MIF levels were found to be elevated in subjects with prediabetes compared to controls (26.46 ± 16.98 versus 17.44 ± 11.80 ng/mL, P = 0.007). MIF positively correlated with BMI, visceral fat mass and indirect indices of homeostasis model assessment of insulin resistance. In linear regression model, an independent association was found between MIF levels and metabolic parameters, including BMI, visceral fat mass and homeostasis model assessment of insulin resistance. Multivariate logistic regression analyses revealed that the odds ratio for prediabetes was higher in subjects in the highest quartile of MIF compared to those in the lowest quartile, after adjusting for potential confounders.Conclusions
Increased MIF levels are associated with the elevation of prediabetic risk. 相似文献63.
Kadhim Sulaiman Prashanth Panduranga Ibrahim Al‐Zakwani Alawi A. Alsheikh‐Ali Khalid F. AlHabib Jassim Al‐Suwaidi Wael Al‐Mahmeed Hussam AlFaleh Abdelfatah Elasfar Ahmed Al‐Motarreb Mustafa Ridha Bassam Bulbanat Mohammed Al‐Jarallah Nooshin Bazargani Nidal Asaad Haitham Amin 《European journal of heart failure》2015,17(4):374-384
64.
Fatemeh Haidari Behnaz Abiri Masood Iravani Seyyed-Mohsen Razavi 《Nutrition and cancer》2019,71(5):709-717
The solar ultraviolet B–vitamin D-cancer hypothesis was first suggested in 1980 based on a geographical ecological study. Since then, several ecological and observational studies, as well as researches of mechanisms have supported the hypothesis. Also, the association between vitamin D condition and cancer risk has been assessed in a number of epidemiologic studies, while data from interventional studies remain scant. In regard of cancer locations, the body of evidence is most substantial for colorectal cancer, for which support comes from studies of 25(OH)D, vitamin D intake, and region of residence in a sunny weather. Collectively evidence demonstrates that vitamin D has a potent and beneficial effect at antagonizing and blocking several mitogenic mechanisms related to tumorigenesis. Taken together with the epidemiological studies and limited clinical trials, individuals may need to consider elevating 25(OH)D levels via sun exposure and/or vitamin D supplementation to decrease risk of colorectal cancer, in addition to standard care, treat cancer. 相似文献
65.
Idiotype-pulsed dendritic cell vaccination for B-cell lymphoma: clinical and immune responses in 35 patients 总被引:57,自引:8,他引:57
Timmerman JM Czerwinski DK Davis TA Hsu FJ Benike C Hao ZM Taidi B Rajapaksa R Caspar CB Okada CY van Beckhoven A Liles TM Engleman EG Levy R 《Blood》2002,99(5):1517-1526
Tumor-specific clonal immunoglobulin expressed by B-cell lymphomas (idiotype [Id]) can serve as a target for active immunotherapy. We have previously described the vaccination of 4 patients with follicular lymphoma using dendritic cells (DCs) pulsed with tumor-derived Id protein and now report on 35 patients treated using this approach. Among 10 initial patients with measurable lymphoma, 8 mounted T-cell proliferative anti-Id responses, and 4 had clinical responses--2 complete responses (CRs) (progression-free [PF] for 44 and 57 months after vaccination), 1 partial response (PR) (PF for 12 months), and 1 molecular response (PF for 75+ months). Subsequently, 25 additional patients were vaccinated after first chemotherapy, and 15 of 23 (65%) who completed the vaccination schedule mounted T-cell or humoral anti-Id responses. Induction of high-titer immunoglobulin G anti-Id antibodies required coupling of Id to the immunogenic carrier protein keyhole limpet hemocyanin (Id-KLH). These antibodies could bind to and induce tyrosine phosphorylation in autologous tumor cells. Among 18 patients with residual tumor at the time of vaccination, 4 (22%) had tumor regression, and 16 of 23 patients (70%) remain without tumor progression at a median of 43 months after chemotherapy. Six patients with disease progression after primary DC vaccination received booster injections of Id-KLH protein, and tumor regression was observed in 3 of them (2 CRs and 1 PR). We conclude that Id-pulsed DC vaccination can induce T-cell and humoral anti-Id immune responses and durable tumor regression. Subsequent boosting with Id-KLH can lead to tumor regression despite apparent resistance to the primary DC vaccine. 相似文献
66.
Expression of the human germinal center-associated lymphoma (HGAL) protein, a new marker of germinal center B-cell derivation 总被引:3,自引:1,他引:3
Natkunam Y Lossos IS Taidi B Zhao S Lu X Ding F Hammer AS Marafioti T Byrne GE Levy S Warnke RA Levy R 《Blood》2005,105(10):3979-3986
We identified the human germinal center-associated lymphoma (HGAL) in gene-expression profiling studies of diffuse large B-cell lymphoma (DLBCL). The expression of HGAL correlated with survival in patients with DLBCL. The HGAL gene is the human homolog of M17, a mouse gene expressed specifically in normal germinal center (GC) B cells. We generated a monoclonal antibody against the HGAL protein and show that HGAL is expressed in the cytoplasm of GC lymphocytes and in lymphomas of GC derivation. Among 727 lymphomas tested by immunohistochemistry on tissue microarrays, HGAL staining was found in follicular lymphomas (103 of 107), Burkitt lymphomas (40 of 40), mediastinal large B lymphomas (7 of 8), and in DLBCLs (103 of 151). Most marginal zone lymphomas lacked HGAL staining. Lymphocyte-predominant Hodgkin lymphomas (12 of 17) and, surprisingly, classical Hodgkin lymphomas (78 of 107) were found to be positive. Hierarchical clustering of comparative immunohistologic results in DLBCLs demonstrates that the expression of HGAL is similar to 2 other GC-associated proteins, BCL6 and CD10, but different from 2 markers associated with a non-GC phenotype, MUM1/IRF4 and BCL2. The restricted expression and GC specificity of HGAL protein suggest that it may have an important role in the diagnosis of specific lymphomas, and, potentially in the identification of subtypes associated with different prognoses. 相似文献
67.
68.
Leila Zare Fekri Mohammad Nikpassand Sakineh Pourmirzajani Behnaz Aghazadeh 《RSC advances》2018,8(40):22313
A novel, efficient and one-pot multi-component procedure for the synthesis of simple pyrano[3,2-c]chromen-5(4H)-ones or pyrazolyl pyrano[3,2-c]chromen-5(4H)-ones via reaction of aryl aldehydes, acetophenones and 4-hydroxycoumarin promoted by amino glucose-functionalized silica-coated NiFe2O4 nanoparticles under solvent-free conditions without using any other harmful organic reagents was reported. The structure of this nanoparticle was characterized by transmission electron microscopies, X-ray diffraction and Fourier transform infrared spectroscopies. The catalyst could easily be separated from the reaction mixture by using an external magnetic field and it was reusable. The high purity of the desired products, eco-friendliness, short reaction time and easy workup procedure can be mentioned as the other advantages of this method.We have developed NiFe2O4@SiO2@glucose amine as a new, mild and efficient avenue for the synthesis of pyrano[3,2-c]chromen-5(4H)-ones. 相似文献
69.
Mehdi MOHEBALI Behnaz AKHOUNDI Zahra KAKOOEI Zabih ZAREI Sorour CHAREHDAR Soheila MOLAEI 《Iranian Journal of Parasitology》2015,10(3):360-365
Background: Visceral leishmaniasis is systematic serous parasitic disease with public health importance. Zoonotic form of visceral leishmaniasis is wide spread in Mediterranean basin and South America regions. Direct agglutination test (DAT) is an accurate, reliable and non-expensive serological test for the diagnosis of visceral leishmaniasis in human and canines but the antigen preparation involves some limitations. This study aimed to compare the conventional production of DAT antigen with our modified DAT antigen and then assessed on human and dog pooled sera.
Methods: Conventional DAT antigen has been prepared at the School of Public Health, Tehran University of Medical Sciences and some modifications were carried out on it, which named as modified DAT antigen. Three positive and one negative human and dog pooled serum were separately used for the comparison of modified DAT with conventional DAT antigen batches with one-month interval for a period of 9 months.
Results: A good concordance was observed between modified DAT compared to conventional DAT antigens for the detection of visceral leishmaniasis on human (100%) and dog (94.4%) pooled sera, respectively.
Conclusion: Since the modified DAT antigen could be reduced the preparation time from 3 days to several hours and a good degree of agreement was found between modified DAT and convention DAT antigen batches, it can be used as a simple and easy tool for screening and serodiagnosis of human and canine L. infantum infection.Key Words: Direct agglutination test, Antigen modification, Visceral leishmaniasis 相似文献
70.
Bodurka DC Deavers MT Tian C Sun CC Malpica A Coleman RL Lu KH Sood AK Birrer MJ Ozols R Baergen R Emerson RE Steinhoff M Behmaram B Rasty G Gershenson DM 《Cancer》2012,118(12):3087-3094