全文获取类型
收费全文 | 828篇 |
免费 | 42篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 13篇 |
妇产科学 | 38篇 |
基础医学 | 75篇 |
口腔科学 | 38篇 |
临床医学 | 76篇 |
内科学 | 151篇 |
皮肤病学 | 5篇 |
神经病学 | 46篇 |
特种医学 | 30篇 |
外科学 | 201篇 |
综合类 | 50篇 |
一般理论 | 1篇 |
预防医学 | 35篇 |
眼科学 | 11篇 |
药学 | 37篇 |
肿瘤学 | 73篇 |
出版年
2023年 | 9篇 |
2022年 | 23篇 |
2021年 | 25篇 |
2020年 | 12篇 |
2019年 | 20篇 |
2018年 | 31篇 |
2017年 | 30篇 |
2016年 | 17篇 |
2015年 | 21篇 |
2014年 | 33篇 |
2013年 | 38篇 |
2012年 | 44篇 |
2011年 | 80篇 |
2010年 | 39篇 |
2009年 | 47篇 |
2008年 | 62篇 |
2007年 | 63篇 |
2006年 | 45篇 |
2005年 | 47篇 |
2004年 | 49篇 |
2003年 | 46篇 |
2002年 | 37篇 |
2001年 | 7篇 |
2000年 | 10篇 |
1999年 | 8篇 |
1998年 | 6篇 |
1997年 | 8篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1994年 | 3篇 |
1993年 | 3篇 |
1992年 | 3篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有888条查询结果,搜索用时 259 毫秒
881.
Bradley AJ Kovács IJ Gatherer D Dargan DJ Alkharsah KR Chan PK Carman WF Dedicoat M Emery VC Geddes CC Gerna G Ben-Ismaeil B Kaye S McGregor A Moss PA Pusztai R Rawlinson WD Scott GM Wilkinson GW Schulz TF Davison AJ 《Journal of medical virology》2008,80(9):1615-1623
Most human cytomegalovirus (HCMV) genes are highly conserved in sequence among strains, but some exhibit a substantial degree of variation. Two of these genes are UL146, which encodes a CXC chemokine, and UL139, which is predicted to encode a membrane glycoprotein. The sequences of these genes were determined from a collection of 184 HCMV samples obtained from Africa, Australia, Asia, Europe, and North America. UL146 is hypervariable throughout, whereas variation in UL139 is concentrated in a sequence encoding a potentially highly glycosylated region. The UL146 sequences fell into 14 genotypes, as did all previously reported sequences. The UL139 sequences grouped into 8 genotypes, and all previously reported sequences fell into a subset of these. There were minor differences among continents in genotypic frequencies for UL146 and UL139, but no clear geographical separation, and identical nucleotide sequences were represented among communities distant from each other. The frequent detection of multiple genotypes indicated that mixed infections are common. For both genes, the degree of divergence was sufficient to preclude reliable sequence alignments between genotypes in the most variable regions, and the mode of evolution involved in generating the genotypes could not be discerned. Within genotypes, constraint appears to have been the predominant mode, and positive selection was detected marginally at best. No evidence was found for linkage disequilibrium. The emerging scenario is that the HCMV genotypes developed in early human populations (or even earlier), becoming established via founder or bottleneck effects, and have spread, recombined and mixed worldwide in more recent times. 相似文献
882.
Severe BK polyomavirus‐induced hemorrhagic cystitis in a kidney transplant recipient with the absence of renal allograft involvement
下载免费PDF全文
![点击此处可从《Transplant infectious disease》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Mahwash Kamal Amit Govil Manish Anand Bassam G. Abu Jawdeh Silvi Shah 《Transplant infectious disease》2018,20(1)
BK polyomavirus mostly manifests as polyomavirus‐associated nephropathy (PyVAN) in kidney transplant patients and polyoma virus‐associated hemorrhagic cystitis (PyVHC) in bone marrow transplant patients. PyVHC in kidney transplant patients is only reported in four cases in the literature. Our patient had severe hemorrhagic cystitis without renal involvement. We postulate that our patient's exposure to ifosfamide and radiation 8 years prior transplantation might predispose him to this disease. 相似文献
883.
Mohamad Bassam Sonbol Gina L Mazza Lanyu Mi Thomas Oliver Jason Starr Hallbera Gudmundsdottir Sean P Cleary Timothy Hobday Thorvardur R Halfdanarson 《The oncologist》2022,27(7):573
BackgroundPancreatic neuroendocrine tumors (pNETs) are rare cancers with outcomes determined by multiple factors including grade, stage, and clinical presentation. In this study, we aimed to determine the prognosis of patients with pNETs using a large population-based database.Materials and MethodsIn this population-based study, we identified patients with pNETs from the SEER 18 registry (2000-2016) using a combination of ICD-O-3 and histology codes. We calculated age-adjusted incidence rates using SEER*Stat 8.3.5. In addition, we analyzed overall survival (OS) using the Kaplan-Meier method, and investigated prognostic factors using a multivariable Cox proportional hazards model.ResultsA total of 8944 pNETs patients were identified. Annual incidence rates increased from 0.27 to 1.00 per 100 000. This was largely explained by an increase in number of patients diagnosed with localized disease in more recent years (2012-2016). Median OS was 68 months (95% CI [64, 73]) and 5-year OS rates in localized, regional, and metastatic disease were 83%, 67%, and 28%, respectively. There was a significant improvement in OS for patients diagnosed between 2009 and 2016 (median OS 85 months) compared with those diagnosed between 2000 and 2008 (median OS 46 months) (HR 0.66; 95% CI [0.62, 0.70]). This improvement in OS was consistent across all stages.Conclusions and RelevanceThis study shows a steady increase pNETs incidence with notable stage migration to earlier stages in recent years. This increase in incidence is accompanied by a significant improvement in survival across different disease stages. 相似文献
884.
Ali AlSahow Abdullah Al-Muhaiteeb Hani Nawar Bassam AlHelal Anas AlYousef Emad Abdallah Ahmad AbuShall Sameh Elmekawi Basem Meshal Ahmed AlQallaf Heba AlRajab 《Medical principles and practice》2022,31(2):133
ObjectivesThe aim of this study was to review the use rituximab (RTX) and outcomes in immune-mediated glomerular diseases (glomerulonephritis [GN]) and to compare it to the established literature.MethodsAdult GN patients who received RTX between January 2014 and January 2018 in three public hospitals were reviewed. Membranous nephropathy (MN) and minimal change disease (MCD) were considered diseases with the literature supporting RTX use. Lupus nephritis (LN), primary focal segmental glomerulosclerosis (1<sup>o</sup> FSGS), IgA nephropathy, IgG4-related disease (IgG4-RD), and C3GN had insufficient literature support for RTX use. Clinical remission was assessed 6 months after receiving RTX.ResultsA total of 61 cases were analyzed. RTX was an add-on therapy in 87%. The remission rate was 95% in the MCD and MN versus 56% in the off-label group (p = 0.002). LN patients had a mean initial estimated glomerular filtration rate (eGFR) of 69 mL/min. All class III LN achieved remission, and 11 of 21 class IV achieved remission. The mean initial eGFR for 1<sup>o</sup> FSGS was 33 mL/min, and it did not improve, and only 2 of 5 had partial resolution of proteinuria. Proteinuria improved in 3 of 5 IgG4-RD cases with eGFR stabilization but failed to improve in C3GN cases with eGFR deterioration. Vasculitis cases (6 ANCA-associated vasculitis and 2 IgA vasculitis) were analyzed separately. Remission was achieved in only 2 ANCA-associated vasculitis cases, and none in IgA vasculitis cases.ConclusionsOur data support the use of RTX in resistant MCD and MN. RTX showed success in LN and IgG4-RD but not FSGS or C3GN. The small number of cases of vasculitis does not allow drawing a conclusion on RTX effectiveness. 相似文献
885.
Lucia K. Feldmann MD Roxanne Lofredi MD Bassam Al-Fatly MD PhD Johannes L. Busch MD Varvara Mathiopoulou MSc Jan Roediger MD Patricia Krause MD Gerd-Helge Schneider MD Katharina Faust MD Andreas Horn MD PhD Andrea A. Kühn MD Wolf-Julian Neumann MD 《Movement disorders》2023,38(4):692-697
Background
Subthalamic nucleus (STN) beta (13 - 35 Hz) activity is a biomarker reflecting motor state in Parkinson's disease (PD). Adaptive deep brain stimulation (DBS) aims to use beta activity for therapeutic adjustments, but many aspects of beta activity in real-life situations are unknown.Objective
The aim was to investigate Christmas-related influences on beta activity in PD.Methods
Differences in Christmas Day to nonfestive daily averages in chronic biomarker recordings in 4 PD patients with a sensing-enabled STN DBS implant were retrospectively analyzed. Sweet-spot and whole-brain network connectomic analyses were performed.Results
Beta activity was significantly reduced on Christmas Eve in all patients (4.00–9.00 p.m.: −12.30 ± 10.78%, P = 0.015). A sweet spot in the dorsolateral STN connected recording sites to motor, premotor, and supplementary motor cortices.Conclusions
We demonstrate that festive events can reduce beta biomarker activity. We conclude that circadian and holiday-related changes should be considered when tailoring adaptive DBS algorithms to patient demands. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. 相似文献886.
Nuno Maia Nekane Ibarluzea Mala Misra-Isrie Daniel C. Koboldt Isabel Marques Gabriela Soares Rosário Santos Carlo L. M. Marcelis Riikka Keski-Filppula Miriam Guitart Elisabeth Gabau Vila April Lehman Scott Hickey Mari Mori Paulien Terhal Irene Valenzuela Amaia Lasa-Aranzasti Anna Maria Cueto-González Brian H. Chhouk Rebecca C. Yeh Jennifer E. Neil Bassam Abu-Libde Tjitske Kleefstra Mariet W. Elting Andrea Császár Judit Kárteszi Beáta Bessenyei Hans van Bokhoven Paula Jorge Johanna M. van Hagen Arjan P. M. de Brouwer 《American journal of medical genetics. Part A》2023,191(1):135-143
We describe the phenotype of 22 male patients (20 probands) carrying a hemizygous missense variant in MED12. The phenotypic spectrum is very broad ranging from nonspecific intellectual disability (ID) to the three well-known syndromes: Opitz–Kaveggia syndrome, Lujan–Fryns syndrome, or Ohdo syndrome. The identified variants were randomly distributed throughout the gene (p = 0.993, χ2 test), but mostly outside the functional domains (p = 0.004; χ2 test). Statistical analyses did not show a correlation between the MED12-related phenotypes and the locations of the variants (p = 0.295; Pearson correlation), nor the protein domain involved (p = 0.422; Pearson correlation). In conclusion, establishing a genotype–phenotype correlation in MED12-related diseases remains challenging. Therefore, we think that patients with a causative MED12 variant are currently underdiagnosed due to the broad patients' clinical presentations. 相似文献
887.
888.