全文获取类型
收费全文 | 2428篇 |
免费 | 128篇 |
国内免费 | 119篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 102篇 |
妇产科学 | 29篇 |
基础医学 | 231篇 |
口腔科学 | 160篇 |
临床医学 | 224篇 |
内科学 | 489篇 |
皮肤病学 | 21篇 |
神经病学 | 360篇 |
特种医学 | 164篇 |
外科学 | 295篇 |
综合类 | 39篇 |
一般理论 | 1篇 |
预防医学 | 108篇 |
眼科学 | 17篇 |
药学 | 241篇 |
中国医学 | 1篇 |
肿瘤学 | 181篇 |
出版年
2023年 | 13篇 |
2022年 | 30篇 |
2021年 | 40篇 |
2020年 | 31篇 |
2019年 | 35篇 |
2018年 | 35篇 |
2017年 | 44篇 |
2016年 | 50篇 |
2015年 | 60篇 |
2014年 | 59篇 |
2013年 | 99篇 |
2012年 | 102篇 |
2011年 | 113篇 |
2010年 | 105篇 |
2009年 | 86篇 |
2008年 | 110篇 |
2007年 | 130篇 |
2006年 | 112篇 |
2005年 | 105篇 |
2004年 | 74篇 |
2003年 | 80篇 |
2002年 | 77篇 |
2001年 | 87篇 |
2000年 | 71篇 |
1999年 | 62篇 |
1998年 | 58篇 |
1997年 | 57篇 |
1996年 | 37篇 |
1995年 | 46篇 |
1994年 | 41篇 |
1993年 | 46篇 |
1992年 | 44篇 |
1991年 | 56篇 |
1990年 | 45篇 |
1989年 | 57篇 |
1988年 | 51篇 |
1987年 | 50篇 |
1986年 | 46篇 |
1985年 | 40篇 |
1984年 | 23篇 |
1983年 | 15篇 |
1982年 | 11篇 |
1981年 | 8篇 |
1980年 | 19篇 |
1979年 | 21篇 |
1978年 | 18篇 |
1977年 | 14篇 |
1976年 | 12篇 |
1974年 | 7篇 |
1966年 | 10篇 |
排序方式: 共有2675条查询结果,搜索用时 15 毫秒
91.
Barone Roberto Clauser Carlo Testori Tiziano Del Fabbro Massimo 《Clinical oral investigations》2019,23(8):3257-3265
Clinical Oral Investigations - The aim of this study was to assess the combined role of current radiographic risk indicators and patient age in predicting lower lip sensitivity disturbances after... 相似文献
92.
Michele Barone MD PhD Maria Teresa Viggiani MD Annabianca Amoruso MD Raffaele Licinio MD Andrea Iannone MD Lucia Montenegro MD Maria Principia Scavo PhD Irene Addante BS Alfredo Di Leo MD PhD 《JPEN. Journal of parenteral and enteral nutrition》2014,38(8):991-995
Background: No data about the influence of age and underlying diseases on home enteral nutrition (HEN)–related complications are reported in the literature. Herein, we retrospectively investigated this issue by analyzing HEN‐related complications in a cohort of consecutive patients grouped according to the underlying disease and age. Material and Methods: We reviewed the medical records of 101 patients referring to our team in 2007–2010 to obtain patients’ demographic data, age, nutrition status, duration of HEN treatment, and type of HEN‐related complications. They were divided in cancer and neurologic patients and subgrouped on the basis of their age. HEN‐related complications were expressed as complication rates. Results: Patients with neurological diseases suffered a significantly higher number of complications as compared with cancer patients (P = .04). Age did not significantly influence complication rates. The mechanical complications were the most frequent. The majority of HEN‐related complications were resolved at home. Conclusion: Our data strongly suggest that HEN‐related complications are influenced by underlying diseases and not by age. In neurologic patients, dementia, loss of autonomy, and the different therapies administered by PEG probably play an important role in increasing the number of HEN‐related complications as compared with cancer patients. The most frequent complications can be managed at home, reducing the costs of hospitalizations and discomfort for the patient. 相似文献
93.
Barbara Borroni Francesca Ferrari Daniela Galimberti Benedetta Nacmias Cinzia Barone Silvia Bagnoli Chiara Fenoglio Irene Piaceri Silvana Archetti Cristian Bonvicini Massimo Gennarelli Marinella Turla Elio Scarpini Sandro Sorbi Alessandro Padovani 《Neurobiology of aging》2014
A causative association was recently demonstrated between homozygous TREM2 mutations and frontotemporal dementia (FTD)-like syndrome and between heterozygous TREM2 exon2 genetic variations and late-onset Alzheimer's disease (AD). The objective of this study was to evaluate whether heterozygous TREM2 genetic variations might be associated to the risk of FTD. TREM2 exon 2 was sequenced in a group of 1030 subjects—namely, 352 patients fulfilling clinical criteria for FTD, 484 healthy control subjects (HCs), and 194 patients with AD. The mutation frequency and the associated clinical characteristics were analyzed. We identified 8 missense and nonsense mutations in TREM2 exon 2 in 24 subjects. These mutations were more frequent in patients with FTD than in HCs (4.0% vs. 1.0%, p = 0.005). In particular, TREM2 Q33X, R47H, T66M, and S116C mutations were found in FTD and were absent in HCs. These mutations were associated with either the semantic variant of primary progressive aphasia or the behavioral variant FTD phenotypes. The FTD and AD groups were not significantly different with regard to TREM2 genetic variation frequency (AD: 2.6%, p = 0.39). Heterozygous TREM2 mutations modulate the risk of FTD in addition to increasing susceptibility to AD. Additional studies are warranted to investigate the possible role of these mutations in the pathogenesis of neurodegenerative disorders. 相似文献
94.
Mousavinejad M. Skidmore S. Barone F. G. Tyers P. Pisupati V. Poptani H. Plagge A. Barker R. A. Murray P. Taylor A. Hill C. J. 《Molecular imaging and biology》2020,22(5):1244-1254
Molecular Imaging and Biology - Human pluripotent stem cell (hPSC)-derived dopaminergic neuron progenitor cells (DAPCs) are a potential therapy for Parkinson’s disease (PD). However, their... 相似文献
95.
Prevalence and Clinical Aspects of Mild Cognitive Impairment in Parkinson's Disease: A Meta-Analysis
Chiara Baiano PhD Paolo Barone MD PhD Luigi Trojano MD PhD Gabriella Santangelo PhD 《Movement disorders》2020,35(1):45-54
Mild cognitive impairment associated with Parkinson's disease (PD) is a risk factor for the development of dementia. Despite the importance of early identification of mild cognitive impairment in PD, its prevalence and clinical correlates are still debated. The present meta-analysis provides a robust estimate of prevalence rate of mild cognitive impairment in PD according to the Movement Disorder Society clinical criteria and to explore the differences between PD patients with and without mild cognitive impairment in demographic, clinical, and neuropsychiatric features. A systematic literature search was performed up to April 2019 using PsycInfo (PROQUEST), PubMed, and Scopus. From 4706 titles and abstracts, 41 studies were selected (n = 7053 patients). Pooled mild cognitive impairment prevalence was 40% on a total sample of 7053 PD patients (95% confidence interval = 36–44; Q = 490.14, P < 0.0001; I2 = 91.84%) with a higher frequency for the multiple domain subtype (31%; 95% confidence interval = 23–41, Q = 93.24; P < 0.0001; I2 = 92.49%). Meta-regression analysis revealed that stage of PD moderate prevalence estimates of mild cognitive impairment (β = 2.80; P = 0.008). Mild cognitive impairment in PD was associated with older age, lower education, longer disease duration, higher levodopa equivalent daily dose, more severe motor symptoms, and postural instability/gait difficulty motor subtype, poorer quality of life, higher levels of apathy, and depression. The present meta-analysis indicated that mild cognitive impairment in PD is a frequent cognitive status deserving to be early detected by means of standardized cognitive assessments in clinical practice. © 2019 International Parkinson and Movement Disorder Society 相似文献
96.
Rebecca Dann Tarik Hadi Emilie Montenont Ludovic Boytard Dornaszadat Alebrahim Jordyn Feinstein Nicole Allen Russell Simon Krista Barone Kunihiro Uryu Yu Guo Caron Rockman Bhama Ramkhelawon Jeffrey S. Berger 《Journal of the American College of Cardiology》2018,71(1):53-65
Background
Peripheral artery disease (PAD), a diffuse manifestation of atherothrombosis, is a major cardiovascular threat. Although platelets are primary mediators of atherothrombosis, their role in the pathogenesis of PAD remains unclear.Objectives
The authors sought to investigate the role of platelets in a cohort of symptomatic PAD.Methods
The authors profiled platelet activity, mRNA, and effector roles in patients with symptomatic PAD and in healthy controls. Patients with PAD and carotid artery stenosis were recruited into ongoing studies (NCT02106429 and NCT01897103) investigating platelet activity, platelet RNA, and cardiovascular disease.Results
Platelet RNA sequence profiling mapped a robust up-regulation of myeloid-related protein (MRP)-14 mRNA, a potent calcium binding protein heterodimer, in PAD. Circulating activated platelets were enriched with MRP-14 protein, which augmented the expression of the adhesion mediator, P-selectin, thereby promoting monocyte–platelet aggregates. Electron microscopy confirmed the firm interaction of platelets with monocytes in vitro and colocalization of macrophages with MRP-14 confirmed their cross talk in atherosclerotic manifestations of PAD in vivo. Platelet-derived MRP-14 was channeled to monocytes, thereby fueling their expression of key PAD lesional hallmarks and increasing their directed locomotion, which were both suppressed in the presence of antibody-mediated blockade. Circulating MRP-14 was heightened in the setting of PAD, significantly correlated with PAD severity, and was associated with incident limb events.Conclusions
The authors identified a heightened platelet activity profile and unraveled a novel immunomodulatory effector role of platelet-derived MRP-14 in reprograming monocyte activation in symptomatic PAD. (Platelet Activity in Vascular Surgery and Cardiovascular Events [PACE]; NCT02106429; and Platelet Activity in Vascular Surgery for Thrombosis and Bleeding [PIVOTAL]; NCT01897103) 相似文献97.
Eugenio Barone 《中国神经再生研究》2022,17(2):333
Down syndrome(DS) is the most frequent chromosomal abnormality that causes intellectual disability, resulting from the presence of an extra complete or segment of chromosome 21(HSA21)(Tramutola et al., 2020;Lanzillotta et al., 2021). Every year, approximately 6000 children are born with DS and most of them do not have an autonomous life. 相似文献
98.
99.
Umberto Bracale Ettore Marzano Piero Nastro Marco Barone Diego Cuccurullo Giorgio Cutini Francesco Corcione Giusto Pignata 《Surgical endoscopy》2010,24(10):2475-2479
Background
Esophagojejunostomy (EJS) represents the most difficult steps during totally laparoscopic total gastrectomy (TLTG). Over the past few years, several techniques have been developed. This study aimed to evaluate the feasibility and surgical outcomes of the laparoscopic intracorporeal side-to-side EJS during TLTG used to treat malignant disease of the stomach. 相似文献100.
Francesco Ardito Maria Vellone Alessandra Cassano Agostino M. De Rose Carmelo Pozzo Alessandro Coppola Bruno Federico Ivo Giovannini Carlo Barone Gennaro Nuzzo Felice Giuliante 《Journal of gastrointestinal surgery》2013,17(2):352-359