全文获取类型
收费全文 | 8662篇 |
免费 | 950篇 |
国内免费 | 54篇 |
专业分类
耳鼻咽喉 | 83篇 |
儿科学 | 359篇 |
妇产科学 | 246篇 |
基础医学 | 1316篇 |
口腔科学 | 208篇 |
临床医学 | 1005篇 |
内科学 | 1628篇 |
皮肤病学 | 115篇 |
神经病学 | 790篇 |
特种医学 | 502篇 |
外国民族医学 | 1篇 |
外科学 | 1032篇 |
综合类 | 203篇 |
一般理论 | 3篇 |
预防医学 | 797篇 |
眼科学 | 144篇 |
药学 | 746篇 |
1篇 | |
中国医学 | 18篇 |
肿瘤学 | 469篇 |
出版年
2021年 | 111篇 |
2020年 | 65篇 |
2019年 | 112篇 |
2018年 | 139篇 |
2017年 | 121篇 |
2016年 | 105篇 |
2015年 | 134篇 |
2014年 | 188篇 |
2013年 | 265篇 |
2012年 | 329篇 |
2011年 | 380篇 |
2010年 | 213篇 |
2009年 | 209篇 |
2008年 | 317篇 |
2007年 | 373篇 |
2006年 | 346篇 |
2005年 | 346篇 |
2004年 | 304篇 |
2003年 | 295篇 |
2002年 | 273篇 |
2001年 | 283篇 |
2000年 | 275篇 |
1999年 | 265篇 |
1998年 | 199篇 |
1997年 | 186篇 |
1996年 | 142篇 |
1995年 | 125篇 |
1994年 | 118篇 |
1993年 | 123篇 |
1992年 | 228篇 |
1991年 | 213篇 |
1990年 | 233篇 |
1989年 | 214篇 |
1988年 | 185篇 |
1987年 | 194篇 |
1986年 | 153篇 |
1985年 | 154篇 |
1984年 | 129篇 |
1983年 | 125篇 |
1982年 | 68篇 |
1981年 | 68篇 |
1979年 | 106篇 |
1978年 | 84篇 |
1977年 | 82篇 |
1976年 | 98篇 |
1975年 | 80篇 |
1974年 | 77篇 |
1973年 | 83篇 |
1972年 | 83篇 |
1969年 | 57篇 |
排序方式: 共有9666条查询结果,搜索用时 15 毫秒
71.
The synthesis and localization of alternatively spliced fibronectin EIIIB in resting and thrombin-treated megakaryocytes 总被引:1,自引:1,他引:0
There are several species of alternatively spliced fibronectin (FN). One of these, FN EIIIB, is primarily present in embryonic and in proliferating and migrating cells and is believed to be important for cell maturation. We have studied the synthesis, localization, and secretion of this FN isoform in isolated guinea pig megakaryocytes, nonmegakaryocytic bone marrow cells, and platelets. There was 7.5 times more general FN in megakaryocytes than in nonmegakaryocytic cells based on the analysis of equivalent amounts of protein. FN EIIIB was detected by Western blotting in megakaryocytes but not in nonmegakaryocytic cells present in bone marrow. Neither megakaryocytes nor platelets secreted FN EIIIB, while megakaryocytes secreted 25.3% +/- 4.6% general FN and platelets secreted about 61% general FN in response to thrombin. Analysis of immunostained cells by confocal microscopy revealed that FN EIIIB had been redistributed to the surface of megakaryocytes in response to thrombin. Synthesis was studied by metabolic labeling, and megakaryocytes were shown to synthesize FN and FN EIIIB. Thus, megakaryocytes and platelets are among a small number of adult cells and tissues that synthesize and contain FN EIIIB. The expression of FN EIIIB on the megakaryocyte surface may influence migration and maturation. 相似文献
72.
Intestinal schistosomiasis japonica: CT-pathologic correlation 总被引:1,自引:0,他引:1
Lee RC; Chiang JH; Chou YH; Rubesin SE; Wu HP; Jeng WC; Hsu CC; Tiu CM; Chang T 《Radiology》1994,193(2):539
73.
Jacqueline Barnes 《Child and Adolescent Mental Health》1997,2(4):163-169
There is increasing interest in the influence of community characteristics on child development and family functioning. In order to address questions on community influence, it is important to be aware of the measures available and their strengths and limitations. Useful strategies have been developed within a number of disciplines, including sociology, social and community psychology, and criminology. Methods include summarising information from existing administrative databases and census data, conducting observations, and using survey instruments with residents. The most commonly used methods are reviewed and their psychometric properties described . 相似文献
74.
Leukotriene B4 (LTB4) and the protein kinase C activator, 4-beta-phorbol dibutyrate (PDBu), both induced a pronounced and concentration-dependent stimulation of hydrogen peroxide (H2O2) generation by purified guinea pig peritoneal eosinophils in the concentration range 1 nM-1 microM. The LTB4 response was inhibited competitively by the specific LTB4 receptor antagonist, U-75302, with a KB of 25 nM, while the concentration-response curves for both stimuli were shifted rightwards (3.8-fold and 2.8-fold for LTB4 and PDBu, respectively) by the competitive protein kinase C inhibitor, 1-O-hexadecyl-2-O-methylglycerol at a concentration of 300 microM. LTB4 appears, therefore, to induce respiratory burst in eosinophils via a receptor-mediated mechanism involving protein kinase C. 相似文献
75.
Lesley Barclay RN CM BA MEd Louise Everitt RN CM Post Grad Dip-Comm Health Frances Rogan RN CM B App S M Com Nurs Virginia Schmied RN CM BA MA Hons Aileen Wyllie RN CM BA MHPEd 《Journal of advanced nursing》1997,25(4):719-728
This paper presents the results of a qualitative study conducted by midwife researchers into women's experience of new motherhood. Data were collected using focus groups involving 55 first-time mothers and analysed using grounded theory method. The analysis produced six categories: 'realizing', 'unready', 'drained', 'aloneness', 'loss' and 'working it out'. The core category, 'becoming a mother', integrates all other categories and encapsulates the process of change experienced by women. Also explained are factors mediating the often distressing experience of becoming a mother. The analysis provides a conceptualization of early motherhood enabling the development of strategies for midwives, nurses and others helping women negotiate this challenge. 相似文献
76.
77.
In order to determine the frequency and natural history of benign extracerebral fluid collections, computed tomography reports from a period of 26 months at Oklahoma Children's Memorial Hospital were reviewed (total scans: 3,411). Bilateral frontal extracerebral fluid collections were found in 94 infants under 1 year of age. Eighty-two infants had computed tomography scans as part of the evaluation for macrocrania. Thirteen patients had the typical findings of benign extracerebral fluid collections but otherwise were completely asymptomatic. Longitudinal observation for up to 30 months failed to reveal any changes in neurologic status of these patients. Benign extracerebral fluid collections are a relatively common cause of macrocrania in infants. The presence of these fluid collections is not of immediate concern, providing that clinical evaluations fail to identify either neurologic or developmental abnormalities. 相似文献
78.
Summary— Experiments were designed to determine whether or not indapamide, an antihypertensive agent with vasodilator properties, inhibits endothelium-dependent contractions. Rings of aortae with and without endothelium from spontaneously hypertensive rats (SHR) were suspended in conventional organ chambers for the measurement of isometric force. Acetylcholine and adenosine diphosphate-β-S in the presence of a nitric oxide synthase inhibitor, caused endothelium-dependent contractions, which were inhibited by indapamide. The compound (10−4 M) also slightly reduced the contractions of rings without endothelium evoked by U-46,619, which activates thromboxane-endoperoxide receptors. These results demonstrate that indapamide inhibits endothelium-dependent contractions in the SHR aorta, and suggest that the inhibition is due, at least in part, to the action of the drug on the hypertensive vascular smooth muscle. 相似文献
79.
Loss of heterozygosity mutations of tumor suppressor genes in cytologically atypical areas in chronic lymphocytic thyroiditis 总被引:1,自引:0,他引:1
Hunt JL Baloch ZW Barnes L Swalsky PA Trusky CL Sesatomi E Finkelstein S LiVolsi VA 《Endocrine pathology》2002,13(4):321-330
The relationship between chronic lymphocytic thyroiditis (CLT) and papillary thyroid carcinoma (PTC) is a subject of controversy. Some investigators suggest a causal relationship, whereas others regard the two as only a coincidental occurrence. An additional complicating factor is the presence of atypical nuclei frequently found within lymphoid infiltrates in CLT, which resemble those in PTC. The finding of the RET-PTC translocations in CLT has been reported by two independent groups of investigators, suggesting that the areas of nuclear atypia in CLT are neoplastic rather than reactive. In the present study, we report additional molecular findings that support the hypothesis that the atypical nuclear changes in CLT may be preneoplastic or neoplastic. We microdissected small areas with atypical nuclei in glands with CLT and observed loss-of-heterozygosity mutations of tumor suppressor genes. These genetic mutations are evidence of clonal preneoplastic or neoplastic changes in the follicular cells of CLT. The clinical malignant potential of these minute foci is likely to be very small but remains to be determined. 相似文献
80.
Targeted gene disruption of murine CD7 总被引:2,自引:0,他引:2
CD7 is a 40 kDa type I transmembrane glycoprotein member of the Ig
superfamily. CD7 is a marker of mature human T cells and NK cells, and is
expressed early in their development. Cross-linking CD7 positively
modulates T cell and NK cell activity as measured by calcium fluxes,
expression of adhesion molecules, cytokine secretion and proliferation. CD7
associates directly with phosphoinositol 3'-kinase, and CD7 ligation
induces production of D-3 phosphoinositides and tyrosine phosphorylation.
Severe combined immunodeficiency has been associated with a lack of
lymphocyte surface CD7. The CD7 ligand is unknown. The murine CD7 homolog
is encoded by a single gene on chromosome 11. In order to characterize the
role of CD7 in lymphocyte development and function we have eliminated the
CD7 gene by targeted disruption. CD7- deficient mice display normal
histology of thymus and spleen, normal lymphocyte populations in primary
and secondary lymphoid tissues, and normal serum Ig levels. Specific
antibody responses after immunization with T-dependent and T-independent
antigens are equivalent in wild-type and CD7 knockout mice. CD7-deficient
lymphocytes respond normally to T cell mitogenic and allogeneic stimuli,
and display normal NK cell cytotoxicity.
相似文献