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31.
Růzicka E Streitová H Jech R Kanovský P Roth J Rektorová I Mecír P Hortová H Bares M Hejduková B Rektor I 《Journal of neural transmission (Vienna, Austria : 1996)》2000,107(11):1297-1306
Efficiency and safety of amantadine sulfate (AMS) infusions were investigated in late stage complications of Parkinson's disease (PD). In an open-label study, 21 PD patients suffering from motor fluctuations and/or dyskinesias were administered AMS infusions (PK-Merz, 400 mg per day) during seven days. Oral AMS treatment followed. Significant improvement of UPDRS motor scores was observed between day 0 and day 7, remaining improved until day 21. Based on patients' diary notes, both severity and occurrence of hypokinetic "off" state significantly decreased (from 6.6 to 3.1 hours, p < 0.001, average "off" time per day) as well as dopaminergic-induced dyskinesias (from 2.5 to 1.3 hours, p < 0.05, average duration of dyskinesias per day). AMS infusions followed by oral administration appeared as a safe method for improvement of both motor fluctuations and dyskinesias in advanced PD. In advantage to simple oral therapy, AMS infusions allowed fast introduction of a profound and durable treatment effect. 相似文献
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AA Lapillonne FH Glorieux BL Salle PM Braillon M Chambon J Rigo G Putet J Senterre 《Acta paediatrica (Oslo, Norway : 1992)》1994,83(S405):117-122
Fat and mineral metabolic balance studies were performed in 25 normal very low-birth-weight infants ( 1500 g at birth) fed either pooled pasteurized human milk supplemented with calcium, phosphorus and magnesium, or a preterm formula. Calcium, phosphorus and magnesium intake were similar in both groups and averaged 100mg/kg/day, 72 mg/kg/day and 8 mg/kg/day, respectively. Calcium and phosphorus retention was higher in the subjects fed fortified human milk than in those receiving a preterm formula (65±14 and 62±9mg/kg/day versus 55±12 and 47±7mg/kg/day respectively). The difference was only significant for phosphorus. Magnesium retention was similar in the two groups and averaged 3 mg/kg/day. Fat intake and absorption was significantly higher in the preterm formula fed group than in the one fed fortified human milk (5.5±0.4 g/kg/day and 88±4% versus 4.2±1 g/kg/day, 79±6% respectively). Assessment of the whole body bone mineral content by dual energy X-ray absorptiometry was performed at 3 and 6 months of age in another group of 25 low-birth-weight infants fed either fortified human milk or a preterm formula. Whole body bone mineral content (BMCt) was low (43.3±30.8 g of hydroxyapatite) at 3 months of age (theoretical term) compared to normal full-term newborns at birth. There was no significant influence of the diet. At 6 months of age, BMCt reached 168.6±36.6g, a value similar to that of full-term newborns, with no significant difference between the two regimen groups. The deficit in the 12 subjects who had a BMCt under 30 g at 3 months of age had been corrected at age 6 months. Premature babies fed a pooled pasteurized human milk enriched with calcium, phosphorus and magnesium favored a better retention of calcium and phosphorus. However, no significant influence of the two diets studied was observed on the gain in BMCt over the first 6 months of life. 相似文献
34.
Moderate and severe malnutrition are endemic in much of the developing world and in association with pockets of deprivation in the developed world. The cost in terms of individual and social development is high. The principles of effective management are clearly documented. A low cost, community based treatment programme for moderately and severely malnourished children under 3 years of age was established at a health centre in rural Jamaica. Children were followed up monthly and defaulters were rigorously recalled. Management consisted of carefully delivered dietary advice, antibiotics, anthelminthics, and vitamin supplements. All children improved and the response of 36 children, who were treated in the first year, showed an accelerated weight gain, with catch-up growth and the maintenance of length gain. There was a significant increase in the weight for age, at 1.9% per month over six months, which exceeds the rate reported with food supplementation programmes and nutrition rehabilitation centres. 相似文献
35.
Pathophysiologic considerations as well as non-comparative clinical results suggest that very high purity concentrates may slow immunologic deterioration in human immunodeficiency virus (HIV)-infected hemophiliacs. In an attempt to evaluate this hypothesis, we prospectively compared CD4 cell counts, skin testing responses, and changes of the clinical status in 20 asymptomatic HIV-positive hemophiliacs, randomly assigned to continue the treatment with an intermediate purity concentrate or to receive a very high purity product, purified by immunoaffinity chromatography with monoclonal antibodies. In the group switched to the very high purity concentrate there was no significant change of the CD4 cell counts over the 96-week follow-up period, whereas in the group continued on the intermediate purity concentrate, a highly significant decline was detected (P less than .013). Furthermore, in the very high purity group, four of six anergic patients at entry acquired reactivity to skin testing. The results of this study clearly support the use of very high purity concentrates for the replacement therapy of HIV-infected hemophiliacs. 相似文献
36.
This study was undertaken to explore whether nuclear chromatinconstituents can participate in and/or be affected by redoxreactions catalyzed by nickel, like those of nickel complexeswith small peptides, e.g. tetraglycine (G4) and oxygen. Calfthymus DNA, nucleohistone (NH) or free histones were incubatedat 37°C, pH 7.6, for up to 96 h with nickeI(II)acetate (NiAcet)or nickel subsulfide (M3S2) and/or G4. The effects on DNA andNH were studied by means of melting profiles. Free individualhistones and histones extracted from NH prior to and after exposureto nickel compounds and/or G4 were examined by electro-phoresison polyacrylamide gels. Two-day exposure of DNA to NiAcet, G4,or NiAcet + G4 had no significant effect on its melting temperature.Incubation of NH with NiAcet, however, markedly increased itsmelting temperature by 2.2 ± 0.3°C after 24 h and3.0 ± 0.5°C after 96 % h (P < 0.01 versus NH aloneat either time). Incubation of NH with NiAcet + G4 also resultedin a significant rise of the melting temperature by 1.4 ±0.3°C after 24 h (P <0.05) and 5.5 ± 0.3°Cafter 96 h (P < 0.0001). G4 alone had no effect. Exposureof NH to NiAcet + G4, but not to the individual chemicals, slowlydecreased solubility of the histone components in 0.2 M H2SO4.Only trace amounts of histones could be extracted from NH withacid after 72-h exposure to NiAcet + G4. Treatment of free histoneswith NiAcet, Ni3S2 and/or G4 resulted in a slow random polymerizationof the proteins by NiAcet + G4, Ni3S2 + G4 and Ni3S2 alone,but not NiAcet or G4 alone. The action of Ni3S2 alone was slowerthan that of either nickel compound combined with G4. The presentfindings indicate that nickel carcinogens NiAcet and Ni3S2,in the presence of G4 or even alone (Ni3S2, are capable of causingprotein-protein and perhaps also protein-DNA crosslinking. Reactionsof this type may be involved in the mechanism(s) of nickel carcinogenesis. 相似文献
37.
Masclee AA; Hopman WP; Corstens FH; Rosenbusch G; Jansen JB; Lamers CB 《Radiology》1989,173(2):407-410
Both ultrasonography (US) and cholescintigraphy are used to study gallbladder dynamics. The present study was undertaken to determine whether the two methods provide the same or different information relating to gallbladder emptying. Emptying was simultaneously studied with both methods during infusion of graded physiologic doses of cholecystokinin (CCK) in six healthy subjects. Infusion of stepwise increasing doses of CCK, ranging from 0.03 to 0.5 Ivy dog units per kilogram of body weight per hour (IDU/kg.h), induced significant dose-related increases in plasma CCK, decreases in gallbladder volume assessed with US, and gallbladder emptying assessed with cholescintigraphy. The threshold dose for inducing significant gallbladder emptying was 0.13 IDU/kg.h, as determined with both techniques, indicating similar detection limits. There was a highly significant correlation between decreases in gallbladder volume and decreases in radioactive counts over the gallbladder region, with a tendency toward greater gallbladder responses at sonography during the early phase of gallbladder contraction and toward greater responses at cholescintigraphy during the later phase of gallbladder contraction. It is concluded that these methods can be used interchangeably for the quantitation of gallbladder emptying. 相似文献
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