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71.
肿瘤治疗存在的问题及中西医结合的研究重点 总被引:17,自引:3,他引:17
目前的肿瘤治疗主要存在以下几个问题:(1)肿瘤的过度治疗普遍存在;(2)急功近利而缺乏长远规划;(3)综合治疗缺乏合理的内涵;(4)缺少有效的个体化治疗方案;(5)对中医药的优势认识不足、发挥不够。中西医结合在肿瘤防治中大有可为,应重点围绕以下几个方面开展研究工作:(1)加强中医对恶性肿瘤基础知识的认识和研究;(2)加强中西医结合治疗肿瘤合理化、规范化方案的研究;(3)加强中西医结合治疗恶性肿瘤疗效标准的研究;(4)加强中西医结合防治肿瘤术后复发、转移的研究。 相似文献
72.
José GM Hofhuis Henk F van Stel Augustinus JP Schrijvers Johannes H Rommes Jan Bakker Peter E Spronk 《Critical care (London, England)》2009,13(1):118-3
During recent years increasing attention has been given to the quality of survival in critical care. Health-related quality
of life (HRQOL) is an important issue both for patients and their families. Furthermore, admission to the intensive care unit
can have adverse psychological effects in critically ill patients. Recent studies conducted in critically ill patients have
measured HRQOL. However, usually absent from such reports are evaluations of conceptual issues, addressing factors such as
why HRQOL should be measured in critically ill patients, how to define and standardize domains of HRQOL, whether proxies can
provide useful information about HRQOL in critically ill patients, whether response shift occurs in critically ill patients,
and whether post-traumatic stress disorder (PTSD) occurs in critically ill patients. Some studies reported moderate agreement
between patients and their proxies, although lower levels of agreement may be reported for psychosocial or physical functioning.
Response shift (adaptation and change in perception) appears to be an important phenomenon and likely to be present, but it
is seldom measured when estimating HRQOL in critically ill patients. Furthermore, vigilance for symptoms of PTSD and early
interventions to prevent PTSD are needed. 相似文献
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75.
A Lacout M El Hajjam C Julie P Lacombe JP Pelage 《Journal of Medical Imaging and Radiation Oncology》2008,52(6):580-582
We report the case of a patient with a single liver metastasis of a mucinous colonic carcinoma that mimics a haemangioma in T2‐weighted sequences. Although a very high T2 signal in non‐cystic lesions is highly specific for the diagnostic of haemangioma, the use of gadolinium‐enhancement MRI is recommended. In patients with a history of neoplasia, the diagnosis of benign liver nodules should be made with caution. 相似文献
76.
The frequency of reversible and irreversible visual impairment was determined in children with severe and profound sensorineural deafness, as subnormal vision can adversely affect their educational and social development. Eighty three of 87 such children attending an audiology service were examined to assess the incidence and severity of visual impairment. Each child underwent a detailed ophthalmic assessment. The criteria for visual impairment were visual acuity < 6/9 Snellen or equivalent and/or abnormal binocular vision. Forty five had a normal ophthalmic examination (54.2%). Twenty nine had visual impairment (34.9%) and nine had ophthalmological abnormalities that did not interfere with vision (10.9%). A higher proportion of children with risk factors for visual pathology demonstrated visual impairment than those in whom there were no risk factors. None the less, 44% of visual impairment was among patients without risk factors. The results underline the need to examine all children with severe and profound sensorineural deafness soon after diagnosis and indicate that children with multiple handicaps have a greater likelihood of visual impairment (11 of 14 cases). 相似文献
77.
G Larcos SM Gruenewald JP Fletcher 《Journal of Medical Imaging and Radiation Oncology》1995,39(3):254-256
Recent observations suggest that first degree relatives of patients with an abdominal aortic aneurysm (AAA) are also at risk for the development of this disorder. The first degree relatives of 130 adults with known AAA were invited to attend for an ultrasound examination. Fifty-two eligible relatives (mean age 53 years, range 41–73) from 38 families underwent sonographic screening. Using standard ultrasound criteria no participants were identified with an asymptomatic AAA. Thus, ultrasound of families of patients with AAA has a low yield and may not be useful for screening purposes. 相似文献
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79.
Massé D Voisine C Henry F Cordel S Barbieux I Josien R Meflah K Grégoire M Lieubeau B 《Cancer research》2002,62(4):1050-1056
We have demonstrated previously the ability of apoptotic cells to prime a functional immune response using an i.p. vaccination protocol with apoptotic cells and interleukin 2, before injecting a lethal dose of tumor cells into syngeneic rats. This protocol resulted in a survival rate of 33%. To elucidate the nature and the activity of the phagocytes involved in the clearance of apoptotic cells in vivo, we modulated the peritoneal cavity environment by administrating either thioglycollate or silica i.p. before injecting the apoptotic cells. Our results showed that thioglycollate abrogated vaccination efficiency, because none of the rats survived under these conditions. In fact, thioglycollate treatment induced a massive recruitment and activation of inflammatory macrophages that efficiently engulfed apoptotic cells, bypassing induction of specific immune responses. In contrast, silica treatment enhanced the vaccination efficiency of apoptotic cells plus interleukin 2 up to 66%. We distinguished a population of dendrite-like cells among the cells derived from the silica-treated peritoneal cavity both by their phenotype (MHC II(+)/CD80(+)/CD86(+)) and by their ability to induce the proliferation of allogeneic T cells in a mixed leukocyte reaction. Our results demonstrate the different roles of macrophages and dendritic-like cells in the physiological clearance of dead tumor cells and their implication in the design of immunomodulating vaccines. 相似文献
80.