全文获取类型
收费全文 | 3174篇 |
免费 | 256篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 72篇 |
妇产科学 | 41篇 |
基础医学 | 559篇 |
口腔科学 | 41篇 |
临床医学 | 366篇 |
内科学 | 732篇 |
皮肤病学 | 44篇 |
神经病学 | 266篇 |
特种医学 | 245篇 |
外科学 | 394篇 |
综合类 | 15篇 |
一般理论 | 1篇 |
预防医学 | 310篇 |
眼科学 | 51篇 |
药学 | 162篇 |
肿瘤学 | 134篇 |
出版年
2023年 | 19篇 |
2022年 | 27篇 |
2021年 | 62篇 |
2020年 | 31篇 |
2019年 | 45篇 |
2018年 | 59篇 |
2017年 | 51篇 |
2016年 | 48篇 |
2015年 | 65篇 |
2014年 | 121篇 |
2013年 | 125篇 |
2012年 | 190篇 |
2011年 | 170篇 |
2010年 | 103篇 |
2009年 | 100篇 |
2008年 | 139篇 |
2007年 | 183篇 |
2006年 | 156篇 |
2005年 | 155篇 |
2004年 | 145篇 |
2003年 | 135篇 |
2002年 | 114篇 |
2001年 | 105篇 |
2000年 | 117篇 |
1999年 | 102篇 |
1998年 | 57篇 |
1997年 | 56篇 |
1996年 | 64篇 |
1995年 | 43篇 |
1994年 | 35篇 |
1993年 | 39篇 |
1992年 | 63篇 |
1991年 | 63篇 |
1990年 | 45篇 |
1989年 | 46篇 |
1988年 | 42篇 |
1987年 | 39篇 |
1986年 | 41篇 |
1985年 | 31篇 |
1984年 | 21篇 |
1983年 | 16篇 |
1982年 | 20篇 |
1981年 | 19篇 |
1980年 | 10篇 |
1979年 | 19篇 |
1978年 | 15篇 |
1977年 | 12篇 |
1976年 | 12篇 |
1975年 | 11篇 |
1970年 | 10篇 |
排序方式: 共有3447条查询结果,搜索用时 15 毫秒
81.
Patient‐ and family‐centred care in the intensive care unit: a challenge in the daily practice of healthcare professionals
下载免费PDF全文
![点击此处可从《Journal of clinical nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
82.
Ellen Strijbos Martijn R. Tannemaat Iris Alleman Robert H.P. de Meel Jaap A. Bakker Ruud van Beek Frank P. Kroon Guus F. Rimmelzwaan Jan J.G.M. Verschuuren 《Vaccine》2019,37(7):919-925
Objective
To investigate the efficacy and safety of an influenza vaccination in patients with myasthenia gravis with acetylcholine receptor antibodies (AChR MG).Methods
An influenza vaccination or placebo was administered to 47 AChR MG patients. Before and 4?weeks after administration blood samples and clinical outcome scores were obtained. Antibodies to the vaccine strains A/California/7/2009 (H1N1)pdm09, A/Hong Kong/4801/14 (H3N2) and B/Brisbane/060/08 were measured using the hemagglutination-inhibition (HI) assay and disease-specific AChR antibody titers were measured with a radio-immunoprecipitation assay. Forty-seven healthy controls (HC) were vaccinated with the same influenza vaccine to compare antibody titers.Results
A post-vaccination, seroprotective titer (HI?≥?1:40) was achieved in 89.4% of MG patients vs. 93.6% in healthy controls for the H3N2 strain, 95.7% vs 97.9% for the H1N1 strain and 46.8 vs 51% for the B-strain. A seroprotective titer for all three strains of the seasonal influenza vaccine was reached in 40.4% (19/47) of the MG group and in 51% (24/47) of the HC group. Immunosuppressive medication did not significantly influence post geomean titers (GMT). The titers of disease-specific AChR antibodies were unchanged 4?weeks after vaccination. The clinical outcome scores showed no exacerbation of MG symptoms.Conclusion
The antibody response to an influenza vaccination in patients with AChR MG was not different from that in healthy subjects, even in AChR MG patients using immunosuppressive medication. Influenza vaccination does not induce an immunological or clinical exacerbation of AChR MG.Clinical trial registry
The influenza trial is listed on clinicaltrialsregister.eu under 2016-003138-26. 相似文献83.
84.
85.
J. Klein-Nulend R. F. M. van Oers A. D. Bakker R. G. Bacabac 《Osteoporosis international》2014,25(5):1427-1437
One of the most serious healthcare problems in the world is bone loss and fractures due to a lack of physical activity in elderly people as well as in bedridden patients or otherwise inactive youth. Crucial here are the osteocytes. Buried within our bones, these cells are believed to be the mechanosensors that stimulate bone formation in the presence of mechanical stimuli and bone resorption in the absence of such stimuli. Intercellular signaling is an important physiological phenomenon involved in maintaining homeostasis in all tissues. In bone, intercellular communication via chemical signals like NO plays a critical role in the dynamic process of bone remodeling. If bones are mechanically loaded, fluid flows through minute channels in the bone matrix, resulting in shear stress on the cell membrane that activates the osteocyte. Activated osteocytes produce signaling molecules like NO, which modulate the activity of the bone-forming osteoblasts and the bone-resorbing osteoclasts, thereby orchestrating bone adaptation to mechanical loading. In this review, we highlight current insights in the role of NO in the mechanical adaptation of bone mass and structure, with emphasis on its role in local bone gain and loss as well as in remodeling supervised by osteocytes. Since mechanical stimuli and NO production enhance bone strength and fracture resistance, these new insights may facilitate the development of novel osteoporosis treatments. 相似文献
86.
Purpose
Non-invasive measurements of arterial stiffness including the augmentation index (AIx) and central blood pressure (BP) have been used to assess the cardiovascular health of patients with obstructive sleep apnoea (OSA), a well-established independent risk factor of cardiovascular disease. Continuous positive airway pressure (CPAP) can significantly reduce the AIx, but no studies have analysed the effect of auto-adjusting PAP (APAP) or studied morbidly obese patients with severe OSA at higher risk of cardiovascular disease. In this randomised, single-blinded crossover pilot trial, we aimed to compare the efficacy of CPAP with APAP (ResMed S8 Autoset II) in improving peripheral BP, central BP and the AIx, using SphygmoCor technology. 相似文献87.
Alice Guazzelli Parisa Meysami Emyr Bakker Ezio Bonanni Constantinos Demonacos Marija Krstic-Demonacos 《Expert opinion on investigational drugs》2013,22(8):719-732
Introduction: Malignant pleural mesothelioma (MPM) is a rare neoplasm with a poor prognosis, as current therapies are ineffective. Despite the increased understanding of the molecular biology of mesothelioma, there is still a lack of drugs that dramatically enhance patient survival.Area Covered: This review discusses recent and complete clinical trials supported by the NIH, other U.S. Federal agencies, universities and organizations found on clinicaltrials.gov. Firstly, chemotherapy-based trials are described, followed by immunotherapy and multitargeted therapy. Then we introduce drug repositioning and the use of drug docking as tools to find new interesting molecules. Finally, we highlight potential molecular pathways that may play a role in mesothelioma biology and therapy.Expert Opinion: Numerous biases are present in the clinical trials due to a restricted number of cases, inappropriate endpoints and inaccurate stratification of patients which delay the finding of a treatment for MPM. The most crucial issue of independent research for MPM is the lack of more substantive funding to translate these findings to the clinical setting. However, this approach is not necessarily scientific given the low mutational load of mesothelioma relative to other cancers, and therefore patients need a more solid rationale to have a good chance of successful treatment 相似文献
88.
89.
90.
Esmée A. Bakker Duck-chul Lee Xuemei Sui Thijs M.H. Eijsvogels Francisco B. Ortega I-Min Lee Carl J. Lavie Steven N. Blair 《Mayo Clinic proceedings. Mayo Clinic》2018,93(4):419-428