全文获取类型
收费全文 | 3336篇 |
免费 | 158篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 218篇 |
妇产科学 | 34篇 |
基础医学 | 379篇 |
口腔科学 | 79篇 |
临床医学 | 214篇 |
内科学 | 580篇 |
皮肤病学 | 67篇 |
神经病学 | 111篇 |
特种医学 | 148篇 |
外科学 | 439篇 |
综合类 | 309篇 |
一般理论 | 1篇 |
预防医学 | 159篇 |
眼科学 | 154篇 |
药学 | 385篇 |
中国医学 | 38篇 |
肿瘤学 | 170篇 |
出版年
2023年 | 22篇 |
2022年 | 59篇 |
2021年 | 108篇 |
2020年 | 50篇 |
2019年 | 61篇 |
2018年 | 83篇 |
2017年 | 62篇 |
2016年 | 80篇 |
2015年 | 113篇 |
2014年 | 135篇 |
2013年 | 166篇 |
2012年 | 212篇 |
2011年 | 185篇 |
2010年 | 163篇 |
2009年 | 137篇 |
2008年 | 174篇 |
2007年 | 187篇 |
2006年 | 177篇 |
2005年 | 154篇 |
2004年 | 165篇 |
2003年 | 118篇 |
2002年 | 99篇 |
2001年 | 74篇 |
2000年 | 58篇 |
1999年 | 53篇 |
1998年 | 50篇 |
1997年 | 58篇 |
1996年 | 63篇 |
1995年 | 41篇 |
1994年 | 40篇 |
1993年 | 18篇 |
1992年 | 28篇 |
1991年 | 21篇 |
1990年 | 28篇 |
1989年 | 28篇 |
1988年 | 32篇 |
1987年 | 26篇 |
1986年 | 26篇 |
1985年 | 28篇 |
1984年 | 21篇 |
1983年 | 16篇 |
1982年 | 12篇 |
1981年 | 16篇 |
1980年 | 10篇 |
1979年 | 14篇 |
1978年 | 12篇 |
1977年 | 4篇 |
1975年 | 3篇 |
1974年 | 3篇 |
1965年 | 4篇 |
排序方式: 共有3513条查询结果,搜索用时 0 毫秒
11.
12.
Reports of accessory soleus muscle are rare, perhaps as a result of it often remaining unrecognized. It presents as a swelling behind the ankle and may be mistaken for a tumour or inflammatory lesion, as occurred in the first of a series of three cases. The other two were incidental findings, one in a 30 year old man with an open tibial fracture and the other in a 9 month old child with a club foot. Patients present with either pain or a diagnostic problem. When large, it may make wearing of footwear difficult. Computerized tomography with electromyography enables confirmation of the diagnosis. Pain is relieved by epimysiotomy and when encountered incidentally during surgery, incision of the epimysium is all that is needed. Excision of the muscle may be considered only if wearing of footwear is difficult. The significance of its presence in a case of club foot is unknown. Disinsertion of its insertion was all that was required to obtain surgical correction of the deformity in the present case. Awareness of the condition will prevent unnecessary surgery in asymptomatic cases. 相似文献
13.
14.
15.
Keloid fibroblast responsiveness to epidermal growth factor and activation of downstream intracellular signaling pathways. 总被引:8,自引:0,他引:8
Latha Satish Mary Babu Kien T Tran Patricia A Hebda Alan Wells 《Wound repair and regeneration》2004,12(2):183-192
Keloids, which overgrow the boundaries of the original injury, represent aberrations in the fundamental process of wound healing that include over-abundant cell in-migration, cell proliferation, and inflammation, as well as increased extracellular matrix synthesis and defective remodeling. To understand the key events that result in the formation of these abnormal scars would open new avenues for better understanding of excessive repair, and might provide new therapeutic options. We examined epidermal growth factor receptor (EGFR)-induced cell motility in keloid fibroblasts, as this receptor initiates cell migration during normal wound repair. We show that keloid fibroblasts respond to EGF-induced cell migration but the response is somewhat diminished compared to normal adult fibroblasts (approximately 30% reduced); the mitogenic response was similarly blunted (approximately 5% reduced). Keloid fibroblasts express near normal levels of EGFR (82%), but show a much more attenuated activation of EGFR itself and the motility-associated phospholipase C-gamma. This was reflected in part by rapid loss of EGFR upon exposure to EGF. Interestingly, while extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK-MAPK) activation was relatively robust in keloid fibroblasts, the downstream triggering of the motility-associated calpain activity was blunted. This was reflected by high cell-substratum adhesiveness in the keloid fibroblasts. Thus, the blunted migratory response to EGF noted in keloid fibroblasts appears due to limited activation of two important biochemical switches for cell motility. 相似文献
16.
17.
Seeds of legume species Argyrolobium flaccidum, Desmodium elegans, D. tortuosum, Indigofera gangetica, Lespedeza stenocarpa and Sesbania sesban have been evaluated for the toxicity to rhizobia for the first time. Legume species differ in quantity and quality of released seed toxins to which the symbiotic bacteria respond differentially. Therefore, seed toxicity may be used as a selectable taxonomic marker for the strainal identification of rhizobia. Seed toxins are located in seed coat and are thermolabile to some extent. The seed genotypes, within the species, differ in toxicity and such polymorphism can be used in the selection of toxin-free seeds. Seed surface-disinfection procedures involving subsequent soaking and washing with water are the most useful methods for reducing the seed toxins. The seed toxins from I. gangetica inhibited the growth of its homologous strain but did not affect nodulation and symbiotic parameters. Various seed-toxin-producing legume species did not affect nodulation and symbiotic efficiency and effectiveness. 相似文献
18.
Anaerobic bacteraemia 总被引:1,自引:0,他引:1
19.
A K Deshpande G D Jindal I P Babu S N Nerurkar M D Kelkar G B Parulkar 《Journal of postgraduate medicine》1990,36(2):80-82
Impedance plethysmographic observations have been correlated with aortographic observations in 57 patients suspected of aortic occlusive diseases. Aortic occlusions have been characterised by marked decrease in blood flow index and significant increase in differential pulse arrival time at thigh level bilaterally. Atherosclerotic affection of the aorta has been featured by a bilateral decrease in the value of blood flow index as well as differential pulse arrival time at thigh level. Leriche's syndrome, however, has been found to decrease the blood flow index moderately at thigh in both the legs without any significant change in differential pulse arrival time. Aortography in all the patients has confirmed the diagnosis made by impedance plethysmography. 相似文献
20.
Interaction of human plasma fibronectin with cariogenic and non-cariogenic oral streptococci 总被引:1,自引:17,他引:1 下载免费PDF全文
The interaction of purified human plasma fibronectin (Fn) with bacteria was studied with a variety of oral streptococci. Each of the strains of Streptococcus mutans, Streptococcus salivarius, Streptococcus sanguis, and Streptococcus mitis tested was aggregated by Fn to various degrees, depending on the concentration of Fn added to the test mixtures. Binding assays performed with radiolabeled Fn and various strains of streptococci demonstrated various capabilities to bind Fn, and the amount of Fn bound by each strain was paralleled by its Fn-induced aggregation, with S. mutans 6715 giving the highest values in both assays. Because of the avid binding of Fn by certain strains of potentially cariogenic streptococci, we investigated the possibility that Fn may be present in human saliva and may be adsorbed from saliva onto artificial tooth pellicles. Immunoreactive Fn was detected in paraffin-stimulated whole saliva by enzyme-linked immunosorbent assays of saliva adsorbed onto gelatin-coated cuvettes and by immunoelectroblots (Western blots) of salivary components separated on sodium dodecyl sulfate-polyacrylamide slab gels. Furthermore, immunoreactive Fn was found to be present in artificial tooth pellicles formed by incubating hydroxyapatite beads with whole human saliva. These results demonstrate that certain strains of oral streptococci bind to and are aggregated by Fn. The presence of Fn in artificial tooth pellicles suggests that this macromolecule may play a role in the attachment of potentially cariogenic and other oral streptococci to dental tissues. 相似文献