全文获取类型
收费全文 | 159篇 |
免费 | 11篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 4篇 |
基础医学 | 12篇 |
口腔科学 | 5篇 |
临床医学 | 21篇 |
内科学 | 36篇 |
皮肤病学 | 10篇 |
神经病学 | 4篇 |
特种医学 | 30篇 |
外科学 | 18篇 |
综合类 | 8篇 |
预防医学 | 4篇 |
眼科学 | 2篇 |
药学 | 11篇 |
肿瘤学 | 3篇 |
出版年
2023年 | 1篇 |
2022年 | 1篇 |
2021年 | 1篇 |
2020年 | 3篇 |
2018年 | 3篇 |
2017年 | 3篇 |
2016年 | 7篇 |
2015年 | 4篇 |
2014年 | 2篇 |
2013年 | 2篇 |
2012年 | 3篇 |
2011年 | 1篇 |
2010年 | 9篇 |
2009年 | 9篇 |
2008年 | 2篇 |
2007年 | 9篇 |
2006年 | 2篇 |
2005年 | 2篇 |
2004年 | 8篇 |
2003年 | 2篇 |
2002年 | 2篇 |
2000年 | 2篇 |
1999年 | 1篇 |
1998年 | 7篇 |
1997年 | 5篇 |
1996年 | 6篇 |
1995年 | 1篇 |
1994年 | 4篇 |
1993年 | 4篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 5篇 |
1988年 | 7篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 2篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1982年 | 8篇 |
1980年 | 2篇 |
1978年 | 6篇 |
1977年 | 2篇 |
1976年 | 8篇 |
1975年 | 2篇 |
排序方式: 共有170条查询结果,搜索用时 0 毫秒
71.
72.
Abstract: Until recently, little attention has been directed towards the role the toothbrush may play in human health, even though a report of toothbrush as a significant factor in the infection appeared in 1920. It is common knowledge that the human mouth harbours a wide variety of microorganisms, some of which, at any given time, can be assumed to be potential pathogens. This was not known when toothbrushes were originally designed, yet the common toothbrush has been used in basically the same form for about 200 years. In today's world of organ transplantation and alteration of the immune system, it is important to consider the toothbrush as a source of potential pathogens. Given the fact that very often people will traumatize themselves with their toothbrush, this trauma may become a potential portal of entry for organisms. In this article, we have attempted to demonstrate the importance of toothbrush disinfection, given tips on home toothbrush care and hope to motivate the dentists to educate the patients on the importance of toothbrush disinfection. 相似文献
73.
74.
R. Rosental I. Adamsone D. Babarykin D. Amerika E. Pettersson 《Transplant international》1998,11(S1):S337-S339
Abstract In patients receiving cyclosporine A (CyA) - based immunosuppressive therapy, Ca2+ channel blockers (CCBs) prevent the development of CyA - related nephrotoxicity in which increased Ca2+ content plays an important role. We evaluated the dynamics of the intracellular (erythrocytes) and extracellular (plasma) Ca2+ levels and the influence of the CCB, Phenihydine, on this process during the conversion from Sandimmun (S) to Sandimmun Neoral (SN). Forty-two patients were enrolled. The conversion from S to SN normalized the elevated CA2+ level of erythrocytes in groups with Phenihydine ( n = 20) and without Phenyhidine ( n = 12) 4 weeks after the switch ( P < 0.05); this level remained stable until the end of study. Therefore we suggest that the switch from S to SN is effective in reducing elevated intracellular Ca2+ levels. The decrease of Ca2+ content in erythrocytes was similar in all groups switched to SN (with or without Phenihydine). The last effect should be an important argument to focus the further long-term investigations on the ability of CCBs to act as cytoprotective and nephroprotective agents during immunosuppressive protocols with the new microemulsion formulation of CyA. 相似文献
75.
76.
77.
Background:
Cancer fear and fatalism are believed to be higher in ethnic minorities and may contribute to lower engagement with cancer prevention and early detection. We explored the levels of cancer fear and fatalism in six ethnic groups in the United Kingdom and examined the contribution of acculturation and general fatalism.Methods:
A cross-sectional survey of 720 White British, Caribbean, African, Indian, Pakistani, and Bangladeshi women (120 of each) was conducted. Three items assessed cancer fear and two cancer fatalism. Acculturation was assessed using (self-reported) migration status, ability to speak English, and understanding of health leaflets; general fatalism with a standard measure.Results:
Relative to White British women, African and Indian women were more fearful of cancer, Bangladeshi women less fearful, and Pakistani and Caribbean women were similar to White British women. Cancer fatalism was higher in all the ethnic minority groups compared with White British women. Less acculturated women were less likely to worry (ORs 0.21–0.45, all P<0.05) or feel particularly afraid (ORs 0.11–0.31, all P<0.05) but more likely to feel uncomfortable about cancer (ORs 1.97–3.03, all P<0.05). Lower acculturation (ORs 4.30–17.27, P<0.05) and general fatalism (OR 2.29, P<0.05) were associated with the belief that cancer is predetermined.Conclusions:
In general, cancer fear and fatalism are more prevalent among ethnic minority than White British women and even more so in less acculturated ethnic minorities. This may affect their participation in cancer prevention and early detection. 相似文献78.
79.
80.
Goud PT; Goud AP; Rybouchkin AV; De Sutter P; Dhont M 《Human reproduction (Oxford, England)》1998,13(5):1336-1345
Obtaining karyotypes from human spermatozoa after microinjection into
Syrian golden hamster oocytes is difficult and the hitherto reported
results are unsatisfactory. This may be related to the injection and
culture technique or to the high susceptibility of the hamster oocytes to
undergo parthenogenetic activation or both. Therefore, we investigated the
hamster oocyte-human sperm microinjection model using the following two
approaches: (i) application of contemporary techniques for injection
(touching the sperm tail) and culture (hamster embryo culture medium,
HECM-3, 10% CO2) and (ii) omission of Ca2+ from the injection medium. Thus,
in the first series of experiments, 252 hamster oocytes were injected with
human spermatozoa. Among the 219 (87%) oocytes that survived the injection
procedure, the mean percentages of male pronucleus formation [two pronuclei
(2PN), two polar bodies (PB)], mitotic metaphase entry and sperm chromosome
spreads were 41.4, 27.8 and 18.2% respectively. Analysis of the oocytes
which failed to develop the male pronucleus following injection revealed
that most of them had developed only the hamster female PN while the sperm
nuclei were either intact or swollen (partially decondensed), indicating
that failure of oocyte activation was not the likely reason for the failure
of male PN formation in these oocytes. In the next series of experiments,
sibling oocytes were alternately injected with spermatozoa suspended either
in the regular (1.9 mM Ca2+) or Ca2+-free injection medium (experiment set
2, n=278). A significant improvement was noted in the mean percentages of
oocytes with 2PN, 2PB, metaphase entry and sperm chromosome spreads in the
Ca2+-free group versus the regular group (2PN, 2PB: 51 versus 36.6%,
metaphase entry: 36.3 versus 26.9% and sperm chromosome spreads: 28 versus
20.4%; all P < 0.04). Thus, parthenogenetic activation appears to be one
of the contributing factors for the failure of male PN formation after
heterospecific hamster ICSI. From these experiments it can be concluded
that application of the advanced injection and culture techniques and
omission of Ca2+ from the injection medium are promising for the routine
application of the hamster oocyte microinjection for karyotyping of human
spermatozoa with poor fertilizing capacity.
相似文献