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51.
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53.
Meniru GI; Gorgy A; Podsiadly BT; Craft IL 《Human reproduction (Oxford, England)》1997,12(11):2443-2446
Percutaneous epididymal sperm aspiration (PESA) and intracytoplasmic sperm
injection (ICSI) were carried out in patients with congenital bilateral
absence of the vas deferens (CBAVD) and men with failed reversal of
vasectomy (FRV). PESA was successful in 55 out of 62 patients with CBAVD
(89%) and in 57 out of 60 men with FRV (95%). The fertilization rates after
ICSI (53 and 55%), cleavage rates (70 and 76%) and pregnancy rates (36 and
32%) did not differ significantly between the two respective groups (CBAVD
and FRV). PESA and ICSI are effective both in patients with CBAVD and in
those with FRV.
相似文献
54.
RD Maw † GR Kinghorn ‡ CA Bowman § BT Goh ¶ AT Nayagam M Nathan†† 《Journal of the European Academy of Dermatology and Venereology》2002,16(1):58-62
OBJECTIVES: To determine the safety and efficacy of imiquimod (Aldara) 5% cream in the treatment of prepuce-associated warts in uncircumcised males. METHODS: An open-label study in six UK medical centres with 35 uncircumcised males with prepuce-associated warts treated with imiquimod 5% cream three times per week for up to 16 weeks. Other anogenital warts were also treated. RESULTS: Three times weekly application of imiquimod was found to be safe, with erythema as the most commonly reported local skin reaction. Forty per cent of patients had complete clearance of anogenital warts within 16 weeks. CONCLUSIONS: Imiquimod cream at a dosing regimen of three times per week, is effective and has an acceptable safety profile in the treatment of prepuce associated warts and other external anogenital warts in uncircumcised males. 相似文献
55.
Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease 总被引:6,自引:1,他引:5
Liao A; Nitsch RM; Greenberg SM; Finckh U; Blacker D; Albert M; Rebeck GW; Gomez-Isla T; Clatworthy A; Binetti G; Hock C; Mueller-Thomsen T; Mann U; Zuchowski K; Beisiegel U; Staehelin H; Growdon JH; Tanzi RE; Hyman BT 《Human molecular genetics》1998,7(12):1953-1956
alpha2-Macroglobulin (A2M) is a proteinase inhibitor found in association
with senile plaques (SP) in Alzheimer's disease (AD). A2M has been
implicated biochemically in binding and degradation of the amyloid beta
(Abeta) protein which accumulates in SP. We studied the relationship
between Alzheimer's disease and a common A2M polymorphism, Val1000
(GTC)/Ile1000 (ATC), which occurs near the thiolester active site of the
molecule. In an initial exploratory data set (90 controls and 171
Alzheimer's disease) we noted an increased frequency of the G/G genotype
from 0.07 to 0.12. We therefore tested the hypothesis that the G/G genotype
is over-represented in Alzheimer's disease in an additional independent
data set: a group of 359 controls and 566 Alzheimer's disease patients. In
the hypothesis testing cohort, the G/G genotype increased from 0.07 in
controls to 0.12 in Alzheimer's disease (P < 0.05, Fisher's exact test).
The odds ratio for Alzheimer's disease associated with the G/G genotype was
1.77 (1.16-2.70, P < 0.01) and in combination with APOE4 was 9.68 (95%
CI 3.91-24.0, P < 0.001). The presence of the G allele was associated
with an increase in Abeta burden in a small series. The A2M receptor,
A2M-r/LRP, is a multifunctional receptor whose ligands include
apolipoprotein E and the amyloid precursor protein. These four proteins
have each been genetically linked to Alzheimer's disease, suggesting that
they may participate in a common disease pathway.
相似文献
56.
57.
Anna Parys Elien Vandoorn Jacqueline King Annika Graaf Anne Pohlmann Martin Beer Timm Harder Kristien Van Reeth 《Emerging infectious diseases》2021,27(3):939
We report a zoonotic infection of a pig farmer in the Netherlands with a Eurasian avian-like swine influenza A(H1N1) virus that was also detected in the farmed pigs. Both viruses were antigenically and genetically characterized. Continued surveillance of swine influenza A viruses is needed for risk assessment in humans and swine. 相似文献
58.
Yi-Ping Rong Geert Bultynck Ademuyiwa S. Aromolaran Fei Zhong Jan B. Parys Humbert De Smedt Gregory A. Mignery H. Llewelyn Roderick Martin D. Bootman Clark W. Distelhorst 《Proceedings of the National Academy of Sciences of the United States of America》2009,106(34):14397-14402
Although the presence of a BH4 domain distinguishes the antiapoptotic protein Bcl-2 from its proapoptotic relatives, little is known about its function. BH4 deletion converts Bcl-2 into a proapoptotic protein, whereas a TAT-BH4 fusion peptide inhibits apoptosis and improves survival in models of disease due to accelerated apoptosis. Thus, the BH4 domain has antiapoptotic activity independent of full-length Bcl-2. Here we report that the BH4 domain mediates interaction of Bcl-2 with the inositol 1,4,5-trisphosphate (IP3) receptor, an IP3-gated Ca2+ channel on the endoplasmic reticulum (ER). BH4 peptide binds to the regulatory and coupling domain of the IP3 receptor and inhibits IP3-dependent channel opening, Ca2+ release from the ER, and Ca2+-mediated apoptosis. A peptide inhibitor of Bcl-2-IP3 receptor interaction prevents these BH4-mediated effects. By inhibiting proapoptotic Ca2+ signals at their point of origin, the Bcl-2 BH4 domain has the facility to block diverse pathways through which Ca2+ induces apoptosis. 相似文献
59.
Background
The study was performed to investigate the association of psychological stress and quality of life (QOL) among patients with the cardiovascular disease (CVD) of hypertension plus stroke or hypertension only. 相似文献60.
由于妊娠期母体生理功能的改变,药物更易于通过胎盘进入胎儿体内。妊娠期用药不当可导致胎儿畸形或死亡。本文就耳鼻咽喉科常用的几类药物在妊娠期的应用指征做一编译,以供同道们参考。 相似文献