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Methodological exemplar of integrating quantitative and qualitative evidence – supportive care for men with prostate cancer: what are the most important components? 下载免费PDF全文
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Gastric function was assessed in Wistar rats which received propantheline bromide by daily injection for 20 weeks. The results were compared with those from two control groups, one of which was injected daily with saline for 20 weeks. Gastric acid secretion, as measured by test meal and after ligation of the pylorus, was similar in all three groups. Acid secretion, as measured by test meal with pentagastrin 100 µg/kg body weight, gastric emptying, and fundic mucosal volume, expressed in terms of body weight, were all significantly increased in rats given propantheline. Only those measurements of acid secretion obtained by test meal with pentagastrin showed a significant correlation with fundic mucosal volume. Hence, since this method provides the most accurate indication of secretory capacity, it is concluded that the prolonged parenteral administration of propantheline may lead to an increase in parietal cell mass and its correlate, maximal secretory capacity. The mechanism by which these changes are produced is obscure.The author is grateful to Mr. Howard Ireson for his expert technical assistance, and to Mr. Ralph Marshall, Department of Medical Illustration, Cardiff Royal Infirmary, for the photography employed.Propantheline bromide (Pro-Banthine) was generously supplied by G. D. Searle and Co., Ltd. 相似文献
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Osteomyelitis (bone infection) and neuro-osteoarthropathy (Charcot arthropathy) are limb-threatening complications of diabetic
neuropathy with very different therapies. Distinguishing between them may be difficult, but it is important. In Charcot arthropathy,
noninfectious soft tissue inflammation accompanies rapidly progressive destruction, first of joints, then of bone. This occurs
in a well-vascularized and severely neuropathic, but nonulcerated, foot. In osteomyelitis, chronic soft tissue ulceration
precedes infection of bone, which may be physically exposed. Magnetic resonance imaging and bone biopsy are the preferred
diagnostic tests, provided adequate technical and interpretive skills are available. 相似文献
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Dr. Ramanathan Visvanathan BM BCH FRCS FWACS FICS 《Digestive diseases and sciences》1992,37(10):1600-1605
H+ secretion was studied in guinea pig fundic mucosa incubated in (A) bicarbonate-Ringer's gassed with 95% O2-5% CO2, or (B) HEPES gassed with 100% O2 before and after luminal pH was lowered to 2.0 for periods up to 90 min. At pH 2.0 for 60 min, H+ secretion in group A tissues fell by 35±4% (P=0.02) from a control rate of 1.35±0.09 eq/cm2/hr and in group B tissues by 50±11% (P=0.01) from a control rate of 1.59±0.08 eq/cm2/hr. After 90 min at pH 2.0, H+ secretion in group A fell by 53±8% (P=0.02) from a control rate of 1.47±0.07 eq/cm2/hr and in group B fell by 44±6% (P=0.01) from a control rate of 1.38±0.07 eq/cm2/hr. Histamine 1×10–4 M stimulation following exposure to pH 2.0 for 90 min increased secretion in group A tissues from 0.80 ±0.14 to 1.06±0.13 eq/cm2/hr (P<0.05), compared with an increase in nonacidified controls from 1.15±0.22 to 1.80±0.20 eq/cm2/hr (P<0.05) and in group B tissues from 1.27±0.10 to 1.56±0.19 eq/cm2/hr (P<0.05) compared with nonacidified controls from 1.43±0.22 to 2.23±0.41 eq/cm2/hr (P<0.05). Secretory function and electrical characteristics were adversely affected by luminal acidification to pH 2.0 and suggested a breach in the mucosal barrier with damage to parietal cells.This study was funded by the National Institute of Health Grant No. AM 15681. 相似文献
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Remnant Lipoprotein Cholesterol and Mortality After Acute Myocardial Infarction: Further Evidence for a Hypercholesterolemia Paradox From the TRIUMPH Registry 下载免费PDF全文
Seth S. Martin MD MHS Kamil F. Faridi MD Parag H. Joshi MD MHS Michael J. Blaha MD MPH Krishnaji R. Kulkarni PhD Arif A. Khokhar BM BCh MA Thomas M. Maddox MD Edward P. Havranek MD Peter P. Toth MD PhD Fengming Tang MS John A. Spertus MD MPH Steven R. Jones MD 《Clinical cardiology》2015,38(11):660-667
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Using workload measurement tools in diverse care contexts: the experience of staff in mental health and learning disability inpatient settings 下载免费PDF全文