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排序方式: 共有709条查询结果,搜索用时 15 毫秒
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Hisanori Isomura Ayumu Taguchi Taisuke Kajino Naoya Asai Masahiro Nakatochi Seiichi Kato Keiko Suzuki Kiyoshi Yanagisawa Motoshi Suzuki Teruaki Fujishita Tomoya Yamaguchi Masahide Takahashi Takashi Takahashi 《Cancer science》2021,112(4):1614-1623
We previously reported that ROR1 is a crucial downstream gene for the TTF-1/NKX2-1 lineage-survival oncogene in lung adenocarcinoma, while others have found altered expression of ROR1 in multiple cancer types. Accumulated evidence therefore indicates ROR1 as an attractive molecular target, though it has yet to be determined whether targeting Ror1 can inhibit tumor development and growth in vivo. To this end, genetically engineered mice carrying homozygously floxed Ror1 alleles and an SP-C promoter–driven human mutant EGFR transgene were generated. Ror1 ablation resulted in marked retardation of tumor development and progression in association with reduced malignant characteristics and significantly better survival. Interestingly, gene set enrichment analysis identified a hypoxia-induced gene set (HALLMARK_HYPOXIA) as most significantly downregulated by Ror1 ablation in vivo, which led to findings showing that ROR1 knockdown diminished HIF-1α expression under normoxia and clearly hampered HIF-1α induction in response to hypoxia in human lung adenocarcinoma cell lines. The present results directly demonstrate the importance of Ror1 for in vivo development and progression of lung adenocarcinoma, and also identify Ror1 as a novel regulator of Hif-1α. Thus, a future study aimed at the development of a novel therapeutic targeting ROR1 for treatment of solid tumors such as seen in lung cancer, which are frequently accompanied with a hypoxic tumor microenvironment, is warranted. 相似文献
75.
Kitabatake M Inoue S Yasui F Yokochi S Arai M Morita K Shida H Kidokoro M Murai F Le MQ Mizuno K Matsushima K Kohara M 《Vaccine》2007,25(4):630-637
A vaccine for severe acute respiratory syndrome (SARS) is being intensively pursued against its re-emergence. We generated a SARS coronavirus (SARS-CoV) spike protein-expressing recombinant vaccinia virus (RVV-S) using highly attenuated strain LC16m8. Intradermal administration of RVV-S into rabbits induced neutralizing (NT) antibodies against SARS-CoV 1 week after administration and the NT titer reached 1:1000 after boost immunization with RVV-S. Significantly, NT antibodies against SARS-CoV were induced by administration of RVV-S to rabbits that had been pre-immunized with LC16m8. RVV-S can induce NT antibodies against SARS-CoV despite the presence of NT antibodies against VV. These results suggest that RVV-S may be a powerful SARS vaccine, including in patients previously immunized with the smallpox vaccine. 相似文献
76.
Yuji Kato MD PhD Takeshi Hayashi MD PhD Toshiki Kobayashi MD PhD Ayumu Masuoka MD PhD Tetsuya Abe MD Takahiro Hasebe MD PhD Norio Tanahashi MD PhD Masaki Takao MD PhD 《Headache》2017,57(5):792-795
Coarctation of the aorta (CoA) is reported to be associated with an increased risk for migraine. We describe here the case of a 13‐year‐old female patient who presented migraine with aura after surgical repair of CoA with a stent. As possible reasons for her condition, we postulate host responses to stent placement and/or disturbed cerebral autoregulation related to intracranial hypertension before the surgical repair and hypotension afterward, leading to hypoperfusion. This case demonstrates that de novo migraine with aura can occur after surgical repair of CoA and should be recognized as a potential complication. 相似文献
77.
Neutrophil/lymphocyte ratio as a prognostic indicator of hepatic arterial infusion chemotherapy with arterial cisplatin plus continuous 5‐fluorouracil
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78.
79.
Clinical and molecular genetic characterization of two siblings with trisomy 2p24.3‐pter and monosomy 5p14.3‐pter
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