Risperidone and serum lipid profile changes in child and adolescent patients

Objectives

Atypical antipsychotics (AAPs) have been reported to cause metabolic dysregulation that can cause AAPs-related weight gain. The purpose of this study was to assess triglyceride, cholesterol, and weight changes among risperidone-treated children and youths.

Methods

Eighty-one subjects treated with risperidone for any psychiatric disturbances were included in the study. Fasting total low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglyceride (TG) levels were measured at the baseline and at the sixth month of treatment.

Results

TG, TC and LDL-C levels increased over time and reached statistical significance but there has been no change in HDL-C levels. Seven subjects (8.64%) crossed the threshold into clinically significant hypertriglyceridemia, four subjects (4.94%) crossed the threshold into clinically significant hypercholesterolemia, defined as going over the 95th percentile of published age normed plasma TG and TC levels, respectively. There was a positive correlation between TG and TC elevations and weight gain. There was no significant association with age, gender, diagnoses, risperidone dose and changes of serum TG, TC or LDL-C levels.

Conclusion

The present study identified significant associations between lipid dysregulation and risperidone treatment. Since there is little research available on long-term lipid profile follow-up with atypical antipsychotics treatment in children and youths, controlled studies in larger samples should be carried out to reveal the relationship between risperidone use and plasma lipid parameters in the pediatric population.     

Comparison of Olive Oil and Dry-Clean Keeping Methods in Umbilical Cord Care as Microbiological

The application of olive oil is one of the traditional practices used in umbilical cord care in Turkey. The study was conducted experimentally, so as to compare microbiologically the efficacy of olive oil use and keeping the stump dry. Data were obtained using a personal information form and an omphalitis follow-up form, as well as from cultures taken from the infants’ umbilical cords. Cultures were taken from the neonates’ umbilical cords at three different times. The Pearson chi-square test, student t test, percentages, and averages were used for statistical data analysis. The average time for separation is 9.46 days. For the control group, this period is 9.8 days, while for the study group, it is 9.1, lacking a statistically significant difference between the two groups (P > 0.05). However, when the cut-off point for umbilical cord detachment is set at 10 days, the cords of 71.6% of the neonates in the study group, compared with 55.6% of the control group, are observed to have separated before 10 days, representing a significant difference between the groups (P < 0.05). In all of the cultures collected, growth was noted in 35.9% of the study group and 33.3% of the control group. The correlation between the method used for the care of the cord and the total culture results was not statistically significant (P > 0.05). Olive oil can be used in the umbilical cord care of neonates under appropriate conditions; we recommended that this investigation be repeated on expanded sample groups.     

The quality of sexual life in women with gynaecological cancers

Objectives

This cross-sectional study was conducted with the aim of determining the quality of sexual life and related factors in women with gynaecological cancers.

Methods

The study was conducted in the gynaecological oncology clinic of a state hospital. Women who were diagnosed with gynaecological cancers constituted the study population. Eighty married women who were diagnosed with cancer and who agreed to participate were included in the study. Data were collected by a personal data form, the Sexual Quality of Life (SQOL) Questionnaire-Female and the Multidimensional Scale of Perceived Social Support (MSPSS).

Results

The mean age of the women was 52.16 (SD 10.04). Of the patients, 61.3% had ovarian cancer, 22.5% endometrial cancer, and 13.8% cervical cancer and 56.3% had been diagnosed with cancer during the previous year. Sixty percent of the women were receiving cancer therapy. The mean score of MSPSS was 67.60 (SD 14.03), and SQOL was 52.50 (SD 22.87). Although there was no significant difference between mean SQOL according to individual and disease characteristics, a positive statistically significant relationship was detected between total and subdimension (family, friend and significant other) scores of MSPSS (p?Conclusions According to the results obtained from the study, it can be stated that the sexual quality of life of women with gynaecological cancers is moderate and social support, especially support from a significant person, may affect quality of sexual life positively.     

糖尿病视网膜病变患者高密度脂蛋白-3和总抗氧化能力以及NOx水平分析

目的:比较糖尿病视网膜病变组与对照组数据,以研究高密度脂蛋白-3(HDL3)、NOx和总抗氧化状态之间的关系.方法:前瞻性病例对照研究.106例受试者分为3组,84例2型糖尿病有或无视网膜病变患者,对照组为22例正常人.患者均行血清高密度脂蛋白-3的浓度检测和血清NOx水平测定.用铁还原法(FRAP)测量血浆总抗氧化能力.结果:糖尿病患者(DM)空腹血糖、糖化血红蛋白、甘油三酯显著高于对照组.正常人中HDL3水平为14.4(12.0)mg/dL,糖尿病视网膜病变患者为18.1(12.6)mg/dL,糖尿病无视网膜病变患者为14.0(12.5)mg/dL,组间差异无统计学意义(P=0.262).糖尿病患者FRAP水平低于对照组(P=0.003),但糖尿病视网膜病变组与非糖尿病视网膜病变组之间其差异无统计学意义.结论:研究发现:2型糖尿病视网膜病变患者、糖尿病无视网膜病变患者以及对照组间HDL和HDL3水平无明显不同.HDL3可能无法预测糖尿病视网膜病变患者的患病风险.糖尿病患者中血清NOx水平较高,FRAP水平较低.     

Obstructive sleep apnea is the triggering factor for massive hemoptysis

Purpose

The purpose of this study was to investigate the prevalence of obstructive sleep apnea (OSA) in patients with hemoptysis.

Methods

Files of patients who had undergone bronchial arterial embolization due to hemoptysis between 1 December 2009 and 2015 were evaluated and interviews of patients were conducted until 1 June 2016. Pittsburgh Sleep Quality Index (PSQI), STOP and STOP-BANG surveys were administered. OSA risk was determined with Berlin Questionnaire.

Results

Study group consisted of 53 patients and 58 control subjects. Mean age was 46.94 ± 14.36 and 41.97 ± 12.92 in patient and control group, respectively. Of these patients, seven had re-embolization procedure because of recurrence of hemoptysis. High OSA risk was more common among patients with hemoptysis (24.5%, n = 13) than the control group (8.6%, n = 5) (p = 0.023). Percentage of high risk OSA patients with massive hemoptysis, nonmassive hemoptysis, and control subjects was 29.7% (n = 11), 12.5% (n = 2), and 8.6% (n = 5), respectively (p = 0.022). There were more high OSA risk subjects among patients with idiopathic hemoptysis 44.4% (four out of nine), while 20.5% (nine out of 53) patients with a known etiology had high risk (p = 0.127). The number of patients with high OSA risk was also higher in patients who required a second embolization procedure (four out of seven, 57.1%), while 19.6% of patients without need for re-embolization had high risk (p = 0.031).

Conclusions

OSA is found to be a risk factor for hemoptysis and also may provoke massive hemoptysis. It seems reasonable to consider OSA as an underlying condition in idiopathic hemoptysis. OSA may contribute to embolization failure.