Antioxidant enzyme and malondialdehyde values in social phobia before and after citalopram treatment

A growing body of evidence indicates that oxidative stress is involved in the etiopathogenesis of some psychiatric disorders. In our previous study, we have found that social phobia (SP) seems to be associated with elevated antioxidant enzymes and malondialdehyde (MDA) levels, a lipid peroxidation product. In the present investigation, we sought to determine whether the increased radical burden observed in patients with SP would be attenuated with alleviation of symptoms. Thirty-nine patients diagnosed with generalized SP and 39 healthy controls participated in this study. The measurements of MDA, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) were performed before and after a period of 8 weeks of citalopram treatment. In this period, the patients received citalopram but controls did not. The initial dose of citalopram was 20mg, with 20 mg increments occurring every 2 weeks, to a maximum dose of 60 mg, with the mean daily dose of 38.9 +/- 13.3 mg/day. All patients were evaluated by using Liebowitz Social Anxiety Scale (LSAS). The mean MDA, SOD, GSH-Px and CAT levels of the patient group at baseline were significantly higher than those of controls. Antioxidant enzymes and MDA levels decrease significantly through citalopram treatment. Significant and positive correlation was observed between decrease in the total LSAS scores, and SOD or CAT levels. In conclusion, our results suggest that, in patients with SP, subchronic treatment with citalopram may decrease antioxidant enzymes and MDA values and that they are state markers of SP because they return to normal values with treatment.     

Multiple infiltrating lipomas of the tongue

A rare case of multiple infiltrating lipomas in the tongue of a 54-year-old man is reported. There have been only five previously reported cases of infiltrating lipoma of the tongue. They were all solitary in nature. The present lesion is the first case reported in the English literature of multiple infiltrating lipoma of the tongue. Because of its infiltrating nature, this tumour may be mistaken for a liposarcoma. Achievement of adequate surgical margins is essential, as the recurrence rate may be as high as 62.5 per cent without complete excision.     

Free radicals in patients with post-traumatic stress disorder

There is mounting evidence indicating that reactive free radical species (FRs) are involved in initiation and development of many different forms of human pathologies including psychiatric disorders. In the present study, we aimed to determine whether antioxidant enzyme (glutathione peroxidase, GSH-Px; superoxide dismutase, SOD and catalase, CAT) activities and malondialdehyde (MDA) levels, a product of lipid peroxidation, were associated with post-traumatic stress disorder (PTSD). The study comprised 14 patients who had been diagnosed with PTSD according to DSM-IV criteria and met the admission criteria and 14 healthy controls. The activities of GSH-Px SOD, CAT and MDA were measured in both the patients and controls. In addition, all patients were assessed using the Clinician Administered PTSD Scale (CAPS). The mean GSH-Px, SOD, CAT activities and MDA levels of the patient group did not differ from those of the controls. However, in patients, the GSH-Px and SOD activities were significantly and positively correlated with CAPS scores, while there was a trend toward positive correlations between CAPS scores and MDA or CAT. In conclusion, our results suggest that the production of FRs does not seem to be related to PTSD.     

Etiology of deafness at the Yeditepe School for the deaf in Istanbul

OBJECTIVE: The etiology of deafness can be classified as genetic, acquired and unknown. An unknown etiology was a high incidence in previous reports. The aim of this study is to explore the etiology of deafness and to reduce the cases in the unknown group. METHODS: This study was conducted on 162 students at the Yeditepe School for the deaf. Otologic, physical and psychological examinations were performed by a team of doctors including four otologists, a geneticist, a dentist, an ophthalmologist and an audiologist. RESULTS: A genetic cause was identified in 41.35%, acquired 37.65% and unknown 20.98%. Genetic etiologies were stratified as familial and syndromic subgroups. A familial cause was found in 60 of 162 children and in 22 of those 60 cases, the parents had a consanguineous marriage. There was 11 cases associated with a syndrome. Ninety four minor abnormalities have been established in some deaf children. Febrile convulsion (36%) was identified as the most common etiology in acquired cases. CONCLUSION: In contrast with other studies the consanguineous marriage was present in 36.6% of the familial cases and 38.8% in total of the school. An unknown etiology was reported in high rates in previous reports. These unknown cases could be described as a part of a syndrome by a crowded team of consultants. Evaluation of early diagnostic criterias and minor abnormalities can help us to provide early rehabilitation of deafness in childhood.     

Paradoxical embolism in Ebstein’s anomaly

A 26-year-old man with Ebstein’s anomaly had cerebellar infarction due to paradoxical embolism. Ebstein’s anomaly is characterized by a downward displacement of the tricuspid valve into the right ventricle due to anomalous attachment of the tricuspid leaflets. Echocardiography is the method of choice to diagnose Ebstein’s anomaly on its own or in association with other heart defects. Paradoxical embolism is a potential complication whenever a right to left shunt exists (for example, atrial septal defect). Ebstein’s anomaly diagnosed in adult life is a benign and stable disease, particularly if the patient is asymptomatic; surgical correction must be performed if the patient becomes symptomatic because of either paradoxical embolism or worsening of the tricuspid regurgitation.     

Atypical meningioma and extensive calvarium defects in neurofibromatosis type 1

A 9-year-old girl with neurofibromatosis type 1 (NF1) presented with a massive atypical meningioma and calvarial defect. Skull radiographs and cranial CT showed an extensive lytic bone lesion at the vertex. MRI demonstrated a large mass invading the calvarium and sagittal sinus. The histopathological and immunohistochemical diagnosis of the resected mass was atypical meningioma. To our knowledge, this is the first case of NF1 associated with atypical meningioma and massive calvarial defect in a child.     

Does Obesity Increase Sexual Dysfunction in Women?

This study was conducted to determine the prevalence of sexual dysfunction among women with obesity who are otherwise healthy and applied to the diet center of a hospital located in Ankara, the capital city of Turkey. The sample included 203 volunteers. Data were collected using the personal data form developed by the authors and the female sexual dysfunction inventory (FSFI). The mean age of the participants was 41.17 ± 8.38 years old. Of the participants, 48.7 % were elementary school graduates, 60.6 % were housewives, 64.0 % had the body mass index (BMI) score between 30.00 and 34.99, and the mean BMI score of the participants was 34.73 ± 4.86. Of the participants, 44.3 % stated that being over-weight had adversely affected their sexual life at a score of 6 points or more. Twenty point two of the participants received information regarding sexuality. It is remarkable that health care professionals were found to be the least frequently referred (3 %) resource regarding sexuality. The mean FSFI score of the participants was 27.36 ± 4.80. Severe dysfunction were observed in 12.8 % of the participants. Moreover, all domains of sexual function were dysfunctional. Female sexual function in the present study was not found correlated with several variables, such as the level of education, work status, menopausal status, and knowledge of sexuality. In conclusion, in order to improve women with obesity’s health and well-being diet to lose weight as well as sexual counseling are to be recommended.     

Knowledge and Opinions of Turkish University Students About Contraceptive Methods and Emergency Contraception

This study was carried out to determine the knowledge and opinions of university students about contraceptive methods and emergency contraception (EC). The study comprised 1,689 students who volunteered to participate in the study and were selected from among students studying in two different universities in the 2007–2008 semester. Data were collected on a form that was developed by researchers. The chi-square test was used for the statistical analysis of the data. Oral contraceptive pills (93%), condoms (91.3%), IUDs (Intra Uterine Device) (76.6%) and the withdrawal method (56.8%) were in the lead amongst the contraceptive methods on which students had information. Twenty-nine percent of the students had heard of the concept of EC and 79.8% of those defined the concept accurately. Out of the total student sample, 38.7% stated that they had no information about the methods used for the purpose of EC. 89.6% of the students were of the opinion that every individual should have information about contraceptive methods. Turkish university students were found to be aware of many contraceptive methods; in addition, the opinions of the young university students relating to family planning were positive.