全文获取类型
收费全文 | 11615篇 |
免费 | 543篇 |
国内免费 | 94篇 |
专业分类
耳鼻咽喉 | 120篇 |
儿科学 | 792篇 |
妇产科学 | 1014篇 |
基础医学 | 753篇 |
口腔科学 | 333篇 |
临床医学 | 1266篇 |
内科学 | 2622篇 |
皮肤病学 | 218篇 |
神经病学 | 761篇 |
特种医学 | 320篇 |
外科学 | 1338篇 |
综合类 | 489篇 |
一般理论 | 6篇 |
预防医学 | 858篇 |
眼科学 | 189篇 |
药学 | 473篇 |
中国医学 | 168篇 |
肿瘤学 | 532篇 |
出版年
2023年 | 117篇 |
2022年 | 66篇 |
2021年 | 168篇 |
2020年 | 122篇 |
2019年 | 137篇 |
2018年 | 266篇 |
2017年 | 208篇 |
2016年 | 326篇 |
2015年 | 272篇 |
2014年 | 355篇 |
2013年 | 449篇 |
2012年 | 721篇 |
2011年 | 763篇 |
2010年 | 396篇 |
2009年 | 335篇 |
2008年 | 582篇 |
2007年 | 645篇 |
2006年 | 630篇 |
2005年 | 658篇 |
2004年 | 786篇 |
2003年 | 695篇 |
2002年 | 595篇 |
2001年 | 372篇 |
2000年 | 213篇 |
1999年 | 230篇 |
1998年 | 212篇 |
1997年 | 126篇 |
1996年 | 117篇 |
1995年 | 63篇 |
1994年 | 77篇 |
1993年 | 89篇 |
1992年 | 118篇 |
1991年 | 116篇 |
1990年 | 64篇 |
1989年 | 69篇 |
1988年 | 80篇 |
1987年 | 49篇 |
1986年 | 84篇 |
1985年 | 52篇 |
1984年 | 43篇 |
1983年 | 48篇 |
1982年 | 48篇 |
1981年 | 49篇 |
1980年 | 50篇 |
1979年 | 44篇 |
1978年 | 48篇 |
1977年 | 42篇 |
1975年 | 40篇 |
1973年 | 45篇 |
1972年 | 40篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
121.
122.
伊立替康二线治疗晚期食管癌的临床观察 总被引:3,自引:0,他引:3
目的:观察伊立替康单药二线治疗23例晚期食管癌患者的临床获益率、中位生存期和毒性反应.方法:采用伊立替康单药方案治疗(140mg/m2,静滴90分钟,第1天;120mg/m2,第8天,每3周给药).化疗2-4周期后观察临床获益率、中位生存期和毒性反应.结果:23例患者中,PR 2例(8.7%),SD 11例(47.8%),临床获益率56.5%.中位PFS为2.3个月,中位生存期为5.7个月.主要毒副反应,Ⅲ-Ⅳ度消化道反应5例(21.7%),其中腹泻3例.Ⅲ-Ⅳ度血液学毒性4例(17.4%).结论:对于晚期复发进展的食管癌患者,伊立替康单药方案治疗是安全、有效的二线治疗方案. 相似文献
123.
Gül R. Yılmaz Aliye Tanrıcı Baştuğ Ayşe But Sümeyye Yıldız M. Arzu Yetkin Dilek Kanyılmaz Esragül Akıncı Hürrem Bodur 《Journal of infection and chemotherapy》2013,19(1):57-62
Polymyxins have recently again become important because of multidrug-resistant (MDR) gram-negative pathogens. The aim of this study was to evaluate the clinical and microbiological efficacy and toxicity of different dosages of colistin in patients infected with MDR microorganisms that were sensitive only to colistin. The study was conducted in the 1,200-bed Ankara Numune Training and Research Hospital. Patients with normal renal function who received colistin for 48 h or more were retrospectively evaluated. Clinical response was defined as resolution of fever and clinical and laboratory findings. Microbiological response was defined as bacteriological eradication from the infection site. Nephrotoxicity was defined as at least two consecutive serum creatinine measurements with an increase of 0.5 mg/dl from baseline at least 24 h apart after 2 or more days of colistin therapy. Twenty-four patients were included in the study: total clinical response was obtained in 17 of 24 (70.8 %) patients and microbiological response in 15 of 24 (62.5 %) patients. Patients were grouped according to colistin dosage of 3 × 1 million units (MU) versus 3 × 2 MU. Clinical response rates were 69.2 % and 72.7 %, respectively (p = 0.65). Microbiological response rate was similar (p = 0.62). Nephrotoxicity was revealed in 1 of 13 patients (7.7 %) for the 3 × 1 MU group and 2 of 11 patients (18.2 %) in the 3 × 2 MU group (p = 0.57). The nephrotoxicity rate was greater with higher dosages of colistin, but the difference was not statistically significant. Renal function of patients receiving higher dosages of colistin should be more closely monitored. 相似文献
124.
125.
126.
127.
128.
These financial interests include honoraria; authorship payments; education grants; speakers' bureaus; membership employment stock ownership or other equity interest in an organization with a financial interest; consultancies; expert testimony; patent-licensing arrangements. 《Annals of emergency medicine》2009,53(6):A19
129.
Yazar S Yaman O Demirtaş F Yalçin S Yücesoy M Sahin I 《Acta gastro-enterologica Belgica》2002,65(4):241-244
A 52 year-old male patient with idiopathic hepatic cirrhosis complaining of diarrhea and weakness was accepted to the gastroenterology clinic. In order to find out the causative etiologic agent of diarrhea, stool samples were examined by different methods and stained using modified Kinyoun's acid-fast stain. Following examination, approximately 9 microns diameter, acid-fast variable wrinkled spheres were seen and diagnosed as Cyclospora cayetanensis. Confirmation of the diagnosis was established by fluorescent microscope (380 to 420 nm excitation filter), which showed bright green to intense blue autofluorescent oocysts. It has been shown that, Cyclospora cayetanensis is a coccidian parasite mainly found in immunocompromised patients and that it may be the agent of prolonged diarrhea. Only three cyclosporiosis cases have been previously reported in our country; all three cases were AIDS patients. We report here a further case of Cyclospora cayetanensis infection in a patient with hepatic cirrhosis and we consider that this is the first case, which was reported in hepatic cirrhosis. 相似文献
130.
Mehta RH Harjai KJ Cox DA Stone GW Brodie BR Boura J Grines L O'Neill W Grines CL;Primary Angioplasty in Myocardial Infarction investigators 《The American journal of cardiology》2005,96(7):901-906
Little is known about the influence of stenting versus balloon angioplasty on long-term outcomes (particularly mortality) after primary percutaneous coronary intervention (PCI). We evaluated 2,087 patients with ST-elevation myocardial infarction enrolled in various Primary Angioplasty in Myocardial Infarction (PAMI) trials in the United States, who underwent primary PCI. The main outcome was all-cause mortality at 5 years, obtained through the National Death Index. Of the 2,087 patients, stenting was performed in 692 (33%). The absolute difference in the hospital (2.2% vs 3.3%), 1-year (3.3% vs 5.2%), and 5-year (10% vs 13%) mortality rates favored patients receiving a stent versus conventional balloon therapy, with the difference increasing with time. A multivariate Cox model identified stent use (vs balloon alone) as an independent correlate of lower 5-year mortality (hazard ratio 0.60, 95% confidence interval 0.42 to 0.85). The absolute reduction in mortality was greatest in the highest risk group. In conclusion, compared with balloon angioplasty, stenting during primary PCI not only resulted in better angiographic and short-term outcomes, but also in a sustained beneficial effect on mortality at 5 years. These data support the routine use of coronary stenting in most patients undergoing primary PCI, when feasible. 相似文献