全文获取类型
收费全文 | 1364篇 |
免费 | 68篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 75篇 |
妇产科学 | 17篇 |
基础医学 | 178篇 |
口腔科学 | 71篇 |
临床医学 | 105篇 |
内科学 | 256篇 |
皮肤病学 | 7篇 |
神经病学 | 44篇 |
特种医学 | 137篇 |
外科学 | 182篇 |
综合类 | 43篇 |
一般理论 | 2篇 |
预防医学 | 55篇 |
眼科学 | 78篇 |
药学 | 96篇 |
1篇 | |
中国医学 | 6篇 |
肿瘤学 | 75篇 |
出版年
2023年 | 10篇 |
2022年 | 22篇 |
2021年 | 81篇 |
2020年 | 56篇 |
2019年 | 53篇 |
2018年 | 59篇 |
2017年 | 44篇 |
2016年 | 49篇 |
2015年 | 52篇 |
2014年 | 50篇 |
2013年 | 103篇 |
2012年 | 114篇 |
2011年 | 88篇 |
2010年 | 64篇 |
2009年 | 36篇 |
2008年 | 58篇 |
2007年 | 54篇 |
2006年 | 65篇 |
2005年 | 47篇 |
2004年 | 49篇 |
2003年 | 32篇 |
2002年 | 14篇 |
2001年 | 3篇 |
2000年 | 3篇 |
1999年 | 5篇 |
1998年 | 23篇 |
1997年 | 24篇 |
1996年 | 18篇 |
1995年 | 19篇 |
1994年 | 15篇 |
1993年 | 10篇 |
1991年 | 5篇 |
1990年 | 10篇 |
1989年 | 13篇 |
1988年 | 5篇 |
1987年 | 4篇 |
1986年 | 8篇 |
1985年 | 6篇 |
1984年 | 7篇 |
1982年 | 4篇 |
1981年 | 7篇 |
1980年 | 10篇 |
1978年 | 6篇 |
1977年 | 5篇 |
1976年 | 6篇 |
1975年 | 4篇 |
1961年 | 3篇 |
1958年 | 2篇 |
1954年 | 2篇 |
1953年 | 2篇 |
排序方式: 共有1441条查询结果,搜索用时 828 毫秒
51.
Ardine M. J. Reedijk Eline A. M. Zijtregtop Jan Willem W. Coebergh Friederike A. G. Meyer-Wentrup Konnie M. Hebeda C. Michel Zwaan Geert O. R. Janssens Rob Pieters Wouter J. Plattel Avinash G. Dinmohamed Josée M. Zijlstra Leontien C. M. Kremer Pieternella J. Lugtenburg Auke Beishuizen Henrike E. Karim-Kos 《British journal of haematology》2020,189(6):1093-1106
Population-based studies that assess long-term patterns of incidence, major aspects of treatment and survival are virtually lacking for Hodgkin lymphoma (HL) at a younger age. This study assessed the progress made for young patients with HL (<25 years at diagnosis) in the Netherlands during 1990–2015. Patient and tumour characteristics were extracted from the population-based Netherlands Cancer Registry. Time trends in incidence and mortality rates were evaluated with average annual percentage change (AAPC) analyses. Stage at diagnosis, initial treatments and site of treatment were studied in relation to observed overall survival (OS). A total of 2619 patients with HL were diagnosed between 1990 and 2015. Incidence rates increased for 18–24-year-old patients (AAPC + 1%, P = 0·01) only. Treatment regimens changed into less radiotherapy and more ‘chemotherapy only’, different for age group and stage. Patients aged 15–17 years were increasingly treated at a paediatric oncology centre. The 5-year OS for children was already high in the early 1990s (93%). For patients aged 15–17 and 18–24 years the 5-year OS improved from 84% and 90% in 1990–1994 to 96% and 97% in 2010–2015, respectively. Survival for patients aged 15–17 years was not affected by site of treatment. Our present data demonstrate that significant progress in HL treatment has been made in the Netherlands since 1990. 相似文献
52.
Sanjeev Kumar Sharma Suman Kumar Avinash Kumar Singh Tulika Seth Pravas Mishra Sanjay Sharma Manoranjan Mahapatra 《Indian journal of hematology & blood transfusion》2014,30(1):41-44
Pulmonary complications are one of the most common causes of morbidity and mortality in patients undergoing peripheral blood stem cell transplantation. Both infective and non-infective etiologies can involve the lungs during this period and differentiating them clinically is a challenging task and management differs in each case. We present here a case of acute myeloid leukemia, in whom following allogeneic peripheral blood stem cell transplantation, diffuse alveolar hemorrhage developed. 相似文献
53.
We report the growth of carbon dioxide (CO2) whiskers at low temperatures (−70 °C to −65 °C) and moderate pressure (4.4 to 1.0 bar). Their axial growth was assessed by optical video analysis. The identities of these whiskers were confirmed as CO2 solids by Raman spectroscopy. A vapor–solid growth mechanism was proposed based on the influence of the relative humidity on the growth.Carbon dioxide (CO2) whiskers were reported to grow at low temperatures (−70 °C to −65 °C) and moderate pressure (4.4 to 1.0 bar). 相似文献
54.
Ioannis T Konstantinidis Avinash Kambadakone Onofrio A Catalano Dushyant V Sahani Vikram Deshpe David G Forcione Jennifer A Wargo Carlos Fernandez-del Castillo Keith D Lillemoe Andrew L Warshaw Cristina R Ferrone 《World journal of gastrointestinal surgery》2014,6(7):136-141
AIM: To identify their diagnostic and prognostic clinical characteristics in a large series.METHODS: Retrospective review of clinicopathologic and imaging characteristics of patients diagnosed with lymphoepithelial cysts and cystic lymphangiomas of the pancreas at Massachusetts General Hospital.RESULTS: Twelve patients were identified between 1/1/1997 and 8/1/2007. Their median age was 55.5 years(range 19-78 years), and 6 were females. The le-sion was incidentally discovered in half of the patients.Contrast enhanced computed tomography demonstrat-ed that the cysts had thin walls, without calcifications, pancreatic duct dilation or pancreatic parenchyma inva-sion. Endoscopic ultrasound with fine needle aspiration(EUS/FNA) confirmed the diagnosis of a lymphoepithe-lial cyst in 3 patients, one of whom was spared an op-eration and continues to do well after 6 years. Eleven patients had a resection: 3 pancreaticoduodenecto-mies, 7 distal pancreatectomies, and 1 enucleation. The median size of the cysts was 3 cm(range 2-20 cm). At a median follow-up of 57 mo no recurrences or other pancreas-related conditions occurred.CONCLUSION: Lymphoepithelial cysts and cystic lymphangiomas of the pancreas can be diagnosed with a combination of contrast-enhanced computed tomog-raphy scans and EUS/FNA. If the lesion is asymptom-atic, an operation might be avoided. 相似文献
55.
Avinash Kumar Ekta Rathi Raghu Chandrashekar Hariharapura Suvarna G. Kini 《Medicinal research reviews》2020,40(5):2019-2048
An understanding of the pathology of cervical cancer (CC) mediated by E6/E7 oncoproteins of high-risk human papillomavirus (HPV) was developed by late 80's. But if we look at the present scenario, not a single drug could be developed to inhibit these oncoproteins and in turn, be used specifically for the treatment of CC. The readers are advised not to presume the “viability of E6 protein” as mentioned in the title relates to just druggability of E6. The viability aspect will cover almost everything a researcher should know to develop E6 inhibitors until the preclinical stage. Herein, we have analysed the achievements and shortcomings of the scientific community in the last four decades in targeting HPV E6 against CC. Role of all HPV proteins has been briefly described for better perspective with a little detailed discussion of the role of E6. We have reviewed the articles from 1985 onward, reporting in vitro inhibition of E6. Recently, many computational studies have reported potent E6 inhibitors and these have also been reviewed. Subsequently, a critical analysis has been reported to cover the in vitro assay protocols and in vivo models to develop E6 inhibitors. A paragraph has been devoted to the role of public policy to fight CC employing vaccines and whether the vaccine against HPV has quenched the zeal to develop drugs against it. The review concludes with the challenges and the way forward. 相似文献
56.
Dhiraj Premchandani Akshay Chitnis Avinash Katara Deepraj Bhandarkar 《Asian journal of endoscopic surgery》2020,13(3):435-436
We report a 59‐year‐old man who presented with progressive dyspnea of 30 years. His pulmonary function tests showed reduced forced expiratory volume in the first second and forced vital capacity and computed tomography of the chest showed eventration of the left hemi‐diaphragm. He underwent successful laparoscopic stapled resection / plication of the lax hemi‐diaphragm. He was discharged on the fourth postoperative day with the intercostal drain in situ and this was removed 5 days later at follow up. Postoperatively the pulmonary function showed significant improvement and he remains well 2 years after surgery. 相似文献
57.
Sameera Nayak Taraprasad Das Deepika Parameswarappa Savitri Sharma Saumya Jakati Subhadra Jalali Raja Narayanan Soumyava Basu Mudit Tyagi Vivek Pravin Dave Rajeev Reddy Pappuru Avinash Pathengay Hrishikesh Kaza Padmaja Kumari Rani Shashwat Behera Niroj Kumar Sahoo Aditya Kapoor Hitesh Agrawal Komal Agarwal Brijesh Takkar Vishal Ramesh Raval 《Indian journal of ophthalmology》2021,69(12):3664
Purpose:Intraocular infection in patients with COVID-19 could be different in the presence of treatment with systemic corticosteroid and immunosuppressive agents. We describe the epidemiology and microbiological profile of intraocular infection in COVID-19 patients after their release from the hospital.Methods:We analyzed the clinical and microbiological data of laboratory-confirmed COVID-19 patients from April 2020 to January 2021 presenting with features of endogenous endophthalmitis within 12 weeks of their discharge from the hospital in two neighboring states in South India. The data included demography, systemic comorbidities, COVID-19 treatment details, time interval to visual symptoms, the microbiology of systemic and ocular findings, ophthalmic management, and outcomes.Results:The mean age of 24 patients (33 eyes) was 53.6 ± 13.5 (range: 5–72) years; 17 (70.83%) patients were male. Twenty-two (91.6%) patients had systemic comorbidities, and the median period of hospitalization for COVID-19 treatment was 14.5 ± 0.7 (range: 7–63) days. Infection was bilateral in nine patients. COVID-19 treatment included broad-spectrum systemic antibiotics (all), antiviral drugs (22, 91.66% of patients), systemic corticosteroid (21, 87.5% of patients), supplemental oxygen (18, 75% of patients), low molecular weight heparin (17, 70.8% of patients), admission in intensive care units (16, 66.6% of patients), and interleukin-6 inhibitor (tocilizumab) (14, 58.3% of patients). Five (20.8%) patients died of COVID-19-related complications during treatment for endophthalmitis; one eye progressed to pan ophthalmitis and orbital cellulitis; eight eyes regained vision >20/400. Fourteen of 19 (73.7%) vitreous biopsies were microbiologically positive (culture, PCR, and microscopy), and the majority (11 patients, 78.5%) were fungi.Conclusion:Intraocular infection in COVID-19 patients is predominantly caused by fungi. We suggest a routine eye examination be included as a standard of care of COVID-19. 相似文献
58.
Indications and techniques of biliary drainage for acute cholangitis in updated Tokyo Guidelines 2018
下载免费PDF全文
![点击此处可从《Journal of hepato-biliary-pancreatic sciences》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Shuntaro Mukai Takao Itoi Todd H. Baron Tadahiro Takada Steven M. Strasberg Henry A. Pitt Tomohiko Ukai Satoru Shikata Anthony Yuen Bun Teoh Myung‐Hwan Kim Seiki Kiriyama Yasuhisa Mori Fumihiko Miura Miin‐Fu Chen Wan Yee Lau Keita Wada Avinash Nivritti Supe Mariano Eduardo Giménez Masahiro Yoshida Toshihiko Mayumi Koichi Hirata Yoshinobu Sumiyama Kazuo Inui Masakazu Yamamoto 《Journal of hepato-biliary-pancreatic sciences》2017,24(10):537-549
The Tokyo Guidelines 2013 (TG13) include new topics in the biliary drainage section. From these topics, we describe the indications and new techniques of biliary drainage for acute cholangitis with videos. Recently, many novel studies and case series have been published across the world, thus TG13 need to be updated regarding the indications and selection of biliary drainage based on published data. Herein, we describe the latest updated TG13 on biliary drainage in acute cholangitis with meta‐analysis. The present study showed that endoscopic transpapillary biliary drainage regardless of the use of nasobiliary drainage or biliary stenting, should be selected as the first‐line therapy for acute cholangitis. In acute cholangitis, endoscopic sphincterotomy (EST) is not routinely required for biliary drainage alone because of the concern of post‐EST bleeding. In case of concomitant bile duct stones, stone removal following EST at a single session may be considered in patients with mild or moderate acute cholangitis except in patients under anticoagulant therapy or with coagulopathy. We recommend the removal of difficult stones at two sessions after drainage in patients with a large stone or multiple stones. In patients with potential coagulopathy, endoscopic papillary dilation can be a better technique than EST for stone removal. Presently, balloon enteroscopy‐assisted endoscopic retrograde cholangiopancreatography (BE‐ERCP) is used as the first‐line therapy for biliary drainage in patients with surgically altered anatomy where BE‐ERCP expertise is present. However, the technical success rate is not always high. Thus, several studies have revealed that endoscopic ultrasonography‐guided biliary drainage (EUS‐BD) can be one of the second‐line therapies in failed BE‐ERCP as an alternative to percutaneous transhepatic biliary drainage where EUS‐BD expertise is present. 相似文献
59.
A Homozygous PDE6D Mutation in Joubert Syndrome Impairs Targeting of Farnesylated INPP5E Protein to the Primary Cilium
下载免费PDF全文
![点击此处可从《Human mutation》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Sophie Thomas Kevin J. Wright Stéphanie Le Corre Alessia Micalizzi Marta Romani Avinash Abhyankar Julien Saada Isabelle Perrault Jeanne Amiel Julie Litzler Emilie Filhol Nadia Elkhartoufi Mandy Kwong Jean‐Laurent Casanova Nathalie Boddaert Wolfgang Baehr Stanislas Lyonnet Arnold Munnich Lydie Burglen Nicolas Chassaing Ferechté Encha‐Ravazi Michel Vekemans Joseph G. Gleeson Enza Maria Valente Peter K. Jackson Iain A. Drummond Sophie Saunier Tania Attié‐Bitach 《Human mutation》2014,35(1):137-146
Joubert syndrome (JS) is characterized by a distinctive cerebellar structural defect, namely the « molar tooth sign ». JS is genetically heterogeneous, involving 20 genes identified to date, which are all required for cilia biogenesis and/or function. In a consanguineous family with JS associated with optic nerve coloboma, kidney hypoplasia, and polydactyly, combined exome sequencing and mapping identified a homozygous splice‐site mutation in PDE6D, encoding a prenyl‐binding protein. We found that pde6d depletion in zebrafish leads to renal and retinal developmental anomalies and wild‐type but not mutant PDE6D is able to rescue this phenotype. Proteomic analysis identified INPP5E, whose mutations also lead to JS or mental retardation, obesity, congenital retinal dystrophy, and micropenis syndromes, as novel prenyl‐dependent cargo of PDE6D. Mutant PDE6D shows reduced binding to INPP5E, which fails to localize to primary cilia in patient fibroblasts and tissues. Furthermore, mutant PDE6D is unable to bind to GTP‐bound ARL3, which acts as a cargo‐release factor for PDE6D‐bound INPP5E. Altogether, these results indicate that PDE6D is required for INPP5E ciliary targeting and suggest a broader role for PDE6D in targeting other prenylated proteins to the cilia. This study identifies PDE6D as a novel JS disease gene and provides the first evidence of prenyl‐binding‐dependent trafficking in ciliopathies. 相似文献
60.