全文获取类型
收费全文 | 774篇 |
免费 | 192篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 28篇 |
妇产科学 | 62篇 |
基础医学 | 63篇 |
口腔科学 | 11篇 |
临床医学 | 252篇 |
内科学 | 174篇 |
皮肤病学 | 12篇 |
神经病学 | 36篇 |
特种医学 | 24篇 |
外科学 | 90篇 |
综合类 | 5篇 |
预防医学 | 86篇 |
眼科学 | 17篇 |
药学 | 35篇 |
中国医学 | 4篇 |
肿瘤学 | 63篇 |
出版年
2024年 | 3篇 |
2023年 | 31篇 |
2022年 | 23篇 |
2021年 | 37篇 |
2020年 | 29篇 |
2019年 | 18篇 |
2018年 | 47篇 |
2017年 | 50篇 |
2016年 | 50篇 |
2015年 | 52篇 |
2014年 | 66篇 |
2013年 | 66篇 |
2012年 | 45篇 |
2011年 | 43篇 |
2010年 | 34篇 |
2009年 | 56篇 |
2008年 | 32篇 |
2007年 | 31篇 |
2006年 | 36篇 |
2005年 | 16篇 |
2004年 | 26篇 |
2003年 | 15篇 |
2002年 | 17篇 |
2001年 | 12篇 |
2000年 | 6篇 |
1999年 | 13篇 |
1998年 | 17篇 |
1997年 | 21篇 |
1996年 | 13篇 |
1995年 | 8篇 |
1994年 | 4篇 |
1993年 | 3篇 |
1992年 | 4篇 |
1991年 | 5篇 |
1990年 | 4篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1986年 | 5篇 |
1985年 | 2篇 |
1980年 | 3篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1972年 | 2篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1968年 | 2篇 |
1966年 | 1篇 |
1958年 | 1篇 |
排序方式: 共有969条查询结果,搜索用时 15 毫秒
171.
Andrew Cashin RN MHN NP Dip App Sci BHSC Cert PTT MN PhD FACMHN Claire Newman RN Dip Mental Health Nursing 《Journal of Forensic Nursing》2009,5(2):70-75
Little is known about the experience of people with autism in custody. A review of the literature that explored the relationship between autism and criminality and the criminal justice detention system was conducted. Literature suggests that people with autism are potentially overrepresented within the criminal justice system. There is little research that has examined the experiences of people with autism spectrum disorders in custody. There is very little to guide service design to develop autism support services for people in prison. 相似文献
172.
173.
OBJECTIVE: To investigate the clinical and pharmacoepidemiological determinants of delirium in a psychiatric inpatient population. METHOD: A case-control study design was used. Potential cases and potential controls were identified using hospital discharge data. The clinical record of each subject was reviewed using a validated protocol to confirm case and control status. Subsequently, exposure data were recorded from clinical records. RESULTS: Subjects admitted to hospital with delirium tended to be older, to have pre-existing cognitive deficits, and to have diagnoses of substance use disorders. Subjects who developed delirium after their admission to hospital were older than control subjects, more likely to have a history of cognitive impairment, and were significantly more likely to be treated during the hospitalization with lithium or anticholinergic antiparkinsonian medications. Antipsychotic medication exposures were also associated with delirium, but only at standard or above-standard dosage levels. Antidepressant and sedative-hypnotic medications were not associated with delirium. CONCLUSIONS: These findings indicate that using conservative dosages of antipsychotic medications and minimizing the use of anticholinergic medications for parkinsonian symptoms may help to prevent delirium in psychiatric inpatients. Anticonvulsant mood stabilizers may convey less delirium risk than lithium. Antidepressant medications and sedative-hypnotics were not important determinants of delirium in this population. 相似文献
174.
175.
The lateral superior olive (LSO), a binaural nucleus involved in sound localization, receives tonotopically organized inhibitory inputs from the medial nucleus of the trapezoid body (MNTB). During development, the tonotopic organization of this glycinergic/GABAergic MNTB-LSO pathway is established by activity-dependent axonal reorganization. However, the underlying mechanisms by which this reorganization takes place have remained largely unknown. As cytosolic calcium is one of the most important second messengers responsible for inducing synaptic plasticity and reorganization, we examined whether and how activity in the MNTB-LSO pathway changes the intracellular calcium concentration ([Ca2+]i) in developing LSO neurons. By applying calcium imaging techniques to Fura-2-labelled slices from neonatal rats and mice, we found that glycine and GABA (gamma-aminobutyric acid) affect [Ca2+]i in LSO neurons in an age-dependent manner; during the first postnatal week, the period at which glycine and GABA are depolarizing in the LSO, glycine and GABA always increased [Ca2+]i. However, in 2-week-old animals, the time around hearing onset when glycine and GABA are hyperpolarizing, glycine and GABA slightly decreased [Ca2+]i. Calcium responses could also be elicited by stimulation of afferent fibres from the MNTB, and these synaptic responses were mediated by glycine and GABA(A) receptors. Furthermore, GABA, which is a neurotransmitter only in the immature MNTB-LSO pathway, played a major role in generating MNTB-elicited Ca2+ responses. The direct link of glycinergic/GABAergic synaptic activity to intracellular calcium signalling during the period of inhibitory synaptic plasticity could be one of the mechanisms by which tonotopic MNTB-LSO connections become established. 相似文献
176.
We have identified and molecularly characterized a novel deletion in the beta-globin gene cluster that increases fetal hemoglobin (HbF) synthesis in a 24-year-old Laotian man who is heterozygous for this mutation. The patient is asymptomatic with a mild anemia, hypochromia, and microcytosis (Ht = 39%, MCH = 22.8 pg, MCV = 71 fl), normal levels of HbA2 (3.0%) and 11.5% HbF (G gamma A gamma ratio 60 to 40), with heterocellular distribution (52% F cells). Extensive restriction endonuclease mapping defined the 5' breakpoint within the IVS II of the delta-globin gene, between positions 775 to 781 very similar to the 5' breakpoint of the Sicilian delta beta-thalassemia. However, the 3' breakpoint was localized between two Pst I sites 4.7 kb 3' of the beta- globin gene, thus ending about 0.7 kb upstream from the 3' breakpoint of the Sicilian delta beta-thalassemia. This results in a 12.5 kb deletion of DNA. It is of interest that the 5' breakpoint of the deletion residues within an AT-rich region which has been proposed as a specific recognition signal for recombination events, while the 3' breakpoint lies within a cluster of L1 repetitive sequences (formerly known as Kpn I family repeats). The presence of the 3' breakpoints of several other deletions within this region of L1 repeats also suggests that such sequences might serve as hot spots for recombination and eventually lead to thalassemia deletions. The similarity of the 5' and 3' breakpoints of these delta beta-thalassemias underscores the putative regulatory role of the deleted and juxtaposed sequences on the expression of the gamma-globin genes in adult life. 相似文献
177.
Daniel R. Feikin M. Kariuki Njenga Godfrey Bigogo Barrack Aura Stella Gikunju Amanda Balish Mark A. Katz Dean Erdman Robert F. Breiman 《Clinical and Vaccine Immunology : CVI》2013,20(1):113-114
The role of serology in the setting of PCR-based diagnosis of acute respiratory infections (ARIs) is unclear. We found that acute- and convalescent-phase paired-sample serologic testing increased the diagnostic yield of naso/oropharyngeal swabs for influenza virus, respiratory syncytial virus (RSV), human metapneumovirus, adenovirus, and parainfluenza viruses beyond PCR by 0.4% to 10.7%. Although still limited for clinical use, serology, along with PCR, can maximize etiologic diagnosis in epidemiologic studies. 相似文献
178.
Jeffrey M. Goldberg MD M. Steven Piver MD Ronald E. Hempling MD Christine Aiduk NP Leslie Blumenson PhD Fernando O. Recio MD 《Annals of surgical oncology》1998,5(5):399-406
Background: Since pelvic exenteration for the treatment of recurrent gynecologic malignancy first was described, reported rates of morbidity and mortality have declined steadily. However, the factors responsible for this decline have never been clearly delineated.
Methods: We reviewed the charts of 154 patients who underwent pelvic exenteration for gynecologic malignancy between 1954 and 1994. Charts were abstracted for details of the surgical procedure, pathologic findings, postoperative management, short- and long-term complications, time to recurrence, and overall survival.
Results: Seventy-two patients (47%) experienced 95 identifiable postoperative complications, resulting in death in 22 patients (14%). The rate of infectious complications declined to a statistically significant degree between the first two decades and latter two decades of the study (odds ratio [OR] 0.28, 95% CI 0.11–0.69). The use of routine prophylactic antibiotics was associated with this decline in infectious complications (OR 0.25, 95% CI 0.07–0.83). The use of preoperative subcutaneous heparin was associated with a reduction in thrombotic complications from 5 of 100 patients to 0 of 54 patients (P=.11), as well as a significant reduction in overall risk of complications (OR 0.53, 95% CI 0.33–0.85) and risk of postoperative mortality (OR 0.19, 95% CI 0.05–0.80). There was a significant reduction in overall risk of postoperative complications with both intensive care unit monitoring postoperatively (OR 0.65, 95% CI 0.43–0.99) and routine postoperative monitoring with a pulmonary artery catheter (OR 0.61, 95% CI 0.38–0.98).
Conclusions: Routine use of prophylactic antibiotics, prophylactic subcutaneous heparin, and intensive postoperative monitoring appear to have reduced morbidity from pelvic exenteration. 相似文献
179.
Esther Abels Liron Pantanowitz Famke Aeffner Mark D Zarella Jeroen van der Laak Marilyn M Bui Venkata NP Vemuri Anil V Parwani Jeff Gibbs Emmanuel Agosto-Arroyo Andrew H Beck Cleopatra Kozlowski 《The Journal of pathology》2019,249(3):286-294
In this white paper, experts from the Digital Pathology Association (DPA) define terminology and concepts in the emerging field of computational pathology, with a focus on its application to histology images analyzed together with their associated patient data to extract information. This review offers a historical perspective and describes the potential clinical benefits from research and applications in this field, as well as significant obstacles to adoption. Best practices for implementing computational pathology workflows are presented. These include infrastructure considerations, acquisition of training data, quality assessments, as well as regulatory, ethical, and cyber-security concerns. Recommendations are provided for regulators, vendors, and computational pathology practitioners in order to facilitate progress in the field. © 2019 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. 相似文献
180.
Jeff S. Healey MD Richard Merchant MD Chris Simpson MD Timothy Tang MD Marianne Beardsall MN/NP Stanley Tung MD Jennifer A. Fraser RN Laurene Long RN Janet M. van Vlymen MD Pirjo Manninen MD Fiona Ralley MBBCh Lashmi Venkatraghavan MD Raymond Yee MD Bruce Prasloski MD Shubhayan Sanatani MD Fran?ois Philippon MD 《Journal canadien d'anesthésie》2012,59(4):394-407