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Marcos Aurélio Barboza de Oliveira Ant?nio Carlos Brandi Carlos Alberto dos Santos Paulo Henrique Husseni Botelho José Luís Lasso Cortez Gilberto Goissis Domingo Marcolino Braile 《Brazilian Journal Of Cardiovascular Surgery》2014,29(2):249-254
The calcium paradox was first mentioned in 1966 by Zimmerman et al. Thereafter gained
great interest from the scientific community due to the fact of the absence of
calcium ions in heart muscle cells produce damage similar to ischemia-reperfusion.
Although not all known mechanisms involved in cellular injury in the calcium paradox
intercellular connection maintained only by nexus seems to have a
key role in cellular fragmentation. The addition of small concentrations of calcium,
calcium channel blockers, and hyponatraemia hypothermia are important to prevent any
cellular damage during reperfusion solutions with physiological concentration of
calcium. 相似文献
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Vito D Corleto Cristiano Pagnini Maria Sofia Cattaruzza Ermira Zykaj Emilio Di Giulio Giovanna Margagnoni Emanuela Pilozzi Giancarlo D��Ambra Antonietta Lamazza Enrico Fiori Mario Ferri Luigi Masoni Vincenzo Ziparo Bruno Annibale Gianfranco Delle Fave 《World journal of gastroenterology : WJG》2012,18(45):6614-6619
AIM: To compare the site, age and gender of cases of colorectal cancer (CRC) and polyps in a single referral center in Rome, Italy, during two periods.METHODS: CRC data were collected from surgery/pathology registers, and polyp data from colonoscopy reports. Patients who met the criteria for familial adenomatous polyposis, hereditary non-polyposis colorectal cancer syndrome or inflammatory bowel disease were excluded from the study. Overlap of patients between the two groups (cancers and polyps) was carefully avoided. The χ2 statistical test and a regression analysis were performed.RESULTS: Data from a total of 768 patients (352 and 416 patients, respectively, in periods A and B) who underwent surgery for cancer were collected. During the same time periods, a total of 1693 polyps were analyzed from 978 patients with complete colonoscopies (428 polyps from 273 patients during period A and 1265 polyps from 705 patients during period B). A proximal shift in cancer occurred during the latter years for both sexes, but particularly in males. Proximal cancer increased > 3-fold in period B compared to period A in males [odds ratio (OR) 3.31, 95%CI: 2.00-5.47; P < 0.0001). A similar proximal shift was observed for polyps, particularly in males (OR 1.87, 95%CI: 1.23-2.87; P < 0.0038), but also in females (OR 1.62, 95%CI: 0.96-2.73; P < 0.07).CONCLUSION: The prevalence of proximal proliferative colonic lesions seems to have increased over the last decade, particularly in males. 相似文献