全文获取类型
收费全文 | 3040篇 |
免费 | 123篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 134篇 |
妇产科学 | 35篇 |
基础医学 | 258篇 |
口腔科学 | 30篇 |
临床医学 | 218篇 |
内科学 | 790篇 |
皮肤病学 | 40篇 |
神经病学 | 269篇 |
特种医学 | 64篇 |
外科学 | 641篇 |
综合类 | 75篇 |
预防医学 | 108篇 |
眼科学 | 148篇 |
药学 | 198篇 |
中国医学 | 12篇 |
肿瘤学 | 129篇 |
出版年
2024年 | 4篇 |
2023年 | 21篇 |
2022年 | 49篇 |
2021年 | 125篇 |
2020年 | 61篇 |
2019年 | 75篇 |
2018年 | 77篇 |
2017年 | 60篇 |
2016年 | 85篇 |
2015年 | 96篇 |
2014年 | 131篇 |
2013年 | 159篇 |
2012年 | 237篇 |
2011年 | 264篇 |
2010年 | 165篇 |
2009年 | 120篇 |
2008年 | 217篇 |
2007年 | 228篇 |
2006年 | 197篇 |
2005年 | 179篇 |
2004年 | 166篇 |
2003年 | 142篇 |
2002年 | 128篇 |
2001年 | 16篇 |
2000年 | 24篇 |
1999年 | 16篇 |
1998年 | 24篇 |
1997年 | 14篇 |
1996年 | 9篇 |
1995年 | 12篇 |
1994年 | 11篇 |
1993年 | 10篇 |
1992年 | 1篇 |
1991年 | 6篇 |
1990年 | 10篇 |
1989年 | 4篇 |
1988年 | 1篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1984年 | 5篇 |
1983年 | 7篇 |
1982年 | 1篇 |
1981年 | 2篇 |
1980年 | 3篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1949年 | 1篇 |
排序方式: 共有3172条查询结果,搜索用时 15 毫秒
71.
72.
73.
P. V. M. Lakshmi Atul Sharma Deepak Bhatia Kulbhushan Tikoo Rajesh Kumar 《The American journal of tropical medicine and hygiene》2014,91(4):786-789
Epidemic dropsy is caused by consumption of mustard oil contaminated with argemone oil. It usually occurs in outbreaks with acute manifestation of bilateral pitting edema, erythema, and local tenderness along with cardiac and respiratory problems in severe cases leading to death. We report an outbreak that is unusual because of its gradual onset, clustering in a single family, and with major manifestation of gastrointestinal illness mimicking acute gastroenteritis, hence leading to delayed diagnosis and high mortality. Thus, the diagnosis of epidemic dropsy should be considered as a strong possibility when there is clustering of cases in a single family with on and off gastrointestinal symptoms of vomiting and diarrhea in a mustard oil consuming belt. 相似文献
74.
75.
Estrogens and androgens are instrumental in the maturation of many hormone-dependent cancers. Consequently, the enzymes involved in their synthesis are cancer therapy targets. One such enzyme, steroid sulfatase (STS), hydrolyses estrone sulfate, and dehydroepiandrosterone sulfate to estrone and dehydroepiandrosterone respectively. These are the precursors to the formation of biologically active estradiol and androstenediol. This review focuses on three aspects of STS inhibitors: 1) chemical development, 2) biological activity, and 3) clinical trials. The aim is to discuss the importance of estrogens and androgens in many cancers, the developmental history of STS inhibitor synthesis, the potency of these compounds in vitro and in vivo and where we currently stand in regards to clinical trials for these drugs. STS inhibitors are likely to play an important future role in the treatment of hormone-dependent cancers. Novel in vivo models have been developed that allow pre-clinical testing of inhibitors and the identification of lead clinical candidates. Phase I/II clinical trials in postmenopausal women with breast cancer have been completed and other trials in patients with hormone-dependent prostate and endometrial cancer are currently active. Potent STS inhibitors should become therapeutically valuable in hormone-dependent cancers and other non-oncological conditions. 相似文献
76.
Hernández-Rodríguez J Tan CD Koening CL Khasnis A Rodríguez ER Hoffman GS 《Medicine》2012,91(2):75-85
Testicular vasculitis (TV) may be part of systemic (testicular) vasculitis (STV) or may exist as single-organ/isolated (testicular) vasculitis (ITV). In the current study we sought to identify clinical and histologic features that distinguish STV from ITV. The distinction was deemed important because it is already well established that in other forms of single organ vasculitis, surgical therapy alone may be curative. We identified patients with biopsy-proven TV from pathology databases from our institution and from an English-language PubMed search. Patients were included if data were available to determine TV extent confidently. Data recorded included clinical, laboratory, and histologic features; treatment; and clinical follow-up. The study included 72 patients with TV (mean age, 42 yr; range, 4-78 yr) (7 from our institution). About 74% of patients presented with painful testicular swelling/mass, 10% with a painless testicular swelling/mass, and 4% with epididymal swelling/mass. Eleven percent had no testicular complaints and vasculitis was discovered at autopsy or in other surgical interventions. Vasculitis involved the testicle in 80.3% of cases, the epididymis in 44.6%, and the spermatic cord in 30.6%. Thirty-seven (51%) patients had ITV and 35 (49%) had STV. No differences between ITV and STV patients were found in regards to age, presenting testicular features, duration of testicular symptoms, and time of follow-up. Compared to ITV patients, STV patients presented more often with constitutional/musculoskeletal symptoms (74.3% vs. 8.3%, respectively; p = 0.0001), elevated erythrocyte sedimentation rate (94.7% vs. 16%; p = 0.0001), and anemia (50% vs. 0%; p = 0.0001). Neoplasm was more frequently suspected in ITV than in STV (74.2% vs. 31.6%; p = 0.001), but only occurred in 2 ITV patients. Long-term glucocorticoid therapy was given only to STV patients, and 59.1% of them also received cytotoxic agents. ITV was diagnosed more often by orchiectomy (81.1% vs. 42.9%; p = 0.001) and less frequently by testicular biopsy (2.7% vs. 28.6%; p = 0.003) than STV. Nongranulomatous inflammation affecting medium-sized vessels occurred in most patients with both ITV and STV. Among STV, polyarteritis nodosa was the most frequently diagnosed (63%), followed by Wegener granulomatosis (17%).In summary, TV occurs as ITV in men usually presenting with a testicular mass in the absence of systemic symptoms and normal laboratory results. In most ITV patients, a testicular neoplasm is initially suspected, and TV is an unexpected finding. After surgical removal, ITV does not require systemic therapy. Polyarteritis nodosa is the systemic vasculitis most frequently associated with testicular involvement. 相似文献
77.
78.
79.
80.
To present three rare mimics of primary angiitis of the central nervous system (PACNS). We describe 3 patients with rare diseases
that can mimic PACNS at clinical presentation and neuroimaging. We describe the clinical course of these patients and also
present a review of the literature regarding these three diagnoses. All 3 patients presented with neurological symptoms and
had abnormal findings on neuroimaging suggestive of PACNS. After detailed history, careful review of systems, thorough laboratory
workup and consideration of lack of a response to immunosuppressive therapy, PACNS was ruled out with identification of an
alternative diagnosis. PACNS is a rare disease and a diagnostic challenge with many differentials. A thorough investigation
and awareness of unusual disorders is critical in avoiding misdiagnosis. 相似文献