全文获取类型
收费全文 | 530篇 |
免费 | 15篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 13篇 |
妇产科学 | 48篇 |
基础医学 | 44篇 |
口腔科学 | 5篇 |
临床医学 | 43篇 |
内科学 | 73篇 |
皮肤病学 | 3篇 |
神经病学 | 14篇 |
特种医学 | 20篇 |
外科学 | 116篇 |
综合类 | 14篇 |
预防医学 | 44篇 |
眼科学 | 6篇 |
药学 | 43篇 |
中国医学 | 7篇 |
肿瘤学 | 55篇 |
出版年
2023年 | 8篇 |
2022年 | 14篇 |
2021年 | 17篇 |
2020年 | 10篇 |
2019年 | 10篇 |
2018年 | 24篇 |
2017年 | 11篇 |
2016年 | 6篇 |
2015年 | 12篇 |
2014年 | 26篇 |
2013年 | 33篇 |
2012年 | 33篇 |
2011年 | 35篇 |
2010年 | 27篇 |
2009年 | 17篇 |
2008年 | 30篇 |
2007年 | 30篇 |
2006年 | 17篇 |
2005年 | 20篇 |
2004年 | 19篇 |
2003年 | 21篇 |
2002年 | 19篇 |
2001年 | 9篇 |
2000年 | 7篇 |
1999年 | 4篇 |
1995年 | 3篇 |
1994年 | 6篇 |
1992年 | 8篇 |
1991年 | 7篇 |
1990年 | 9篇 |
1989年 | 4篇 |
1988年 | 4篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 3篇 |
1984年 | 8篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1980年 | 3篇 |
1979年 | 3篇 |
1978年 | 1篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 5篇 |
1973年 | 4篇 |
1972年 | 2篇 |
1971年 | 4篇 |
1970年 | 3篇 |
1960年 | 1篇 |
排序方式: 共有552条查询结果,搜索用时 62 毫秒
551.
Eric R. Griffiths Linda M. Lambert Zhining Ou Akraam Shaaban Maryam Rezvani Waldemar F. Carlo Kurt R. Schumacher Frank DiPaola Matthew J. O'Connor Deipanjan Nandi Steven Zangwill Michael A. McCulloch Joshua M. Friedland-Little Shawn C. West Teresa M. Lee Juan C. Alejos Sharon Chen Kimberly M. Molina 《Pediatric transplantation》2023,27(2):e14435
552.
Iman Ibrahim Salama Samia M Sami Somaia I Salama Ghada A Abdel-Latif Fatma A Shaaban Walaa A Fouad Aida M Abdelmohsen Hala M Raslan 《World journal of hepatology》2023,15(5):585-608
Over 296 million people are estimated to have chronic hepatitis B viral infection (CHB), and it poses unique challenges for elimination. CHB is the result of hepatitis B virus (HBV)-specific immune tolerance and the presence of covalently closed circular DNA as mini chromosome inside the nucleus and the integrated HBV. Serum hepatitis B core-related antigen is the best surrogate marker for intrahepatic covalently closed circular DNA. Functional HBV “cure” is the durable loss of hepatitis B surface antigen (HBsAg), with or without HBsAg seroconversion and undetectable serum HBV DNA after completing a course of treatment. The currently approved therapies are nucleos(t)ide analogues, interferon-alpha, and pegylated-interferon. With these therapies, functional cure can be achieved in < 10% of CHB patients. Any variation to HBV or the host immune system that disrupts the interaction between them can lead to reactivation of HBV. Novel therapies may allow efficient control of CHB. They include direct acting antivirals and immunomodulators. Reduction of the viral antigen load is a crucial factor for success of immune-based therapies. Immu nomodulatory therapy may lead to modulation of the host immune system. It may enhance/restore innate immunity against HBV (as toll-like-receptors and cytosolic retinoic acid inducible gene I agonist). Others may induce adaptive immunity as checkpoint inhibitors, therapeutic HBV vaccines including protein (HBsAg/preS and hepatitis B core antigen), monoclonal or bispecific antibodies and genetically engineered T cells to generate chimeric antigen receptor-T or T-cell receptor-T cells and HBV-specific T cells to restore T cell function to efficiently clear HBV. Combined therapy may successfully overcome immune tolerance and lead to HBV control and cure. Immunotherapeutic approaches carry the risk of overshooting immune responses causing uncontrolled liver damage. The safety of any new curative therapies should be measured in relation to the excellent safety of currently approved nucleos(t)ide analogues. Development of novel antiviral and immune modulatory therapies should be associated with new diagnostic assays used to evaluate the effectiveness or to predict response. 相似文献