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651.
原发性膀胱透明细胞癌(附二例报告并文献复习) 总被引:1,自引:1,他引:0
目的:探讨原发性膀胱透明细胞癌的临床、病理、组织化学特性和诊治方法。方法:回顾分析2例患者临床资料,结合文献复习讨论。结果:2例肿瘤发生于膀胱右侧壁近膀胱颈处,以血尿就诊。组织学以大片透明样癌细胞、腺管样结构为特征。电镜下癌细胞核大而畸形,细胞器较少,部分癌细胞内有细胞内微小腺腔。免疫组化示PAS(+)、AB(+)。1例行膀胱部分切除术,30个月后出现淋巴结转移;1例行肿瘤电切术,15个月后未见复发。结论:此病以血尿为主要症状,病理检查才能确诊,应与转移性癌及肾源型腺瘤相鉴别,治疗以根治性手术为主,预后较其他非尿路上皮癌好。 相似文献
652.
Dan TA Eisenberg James MacKillop Meera Modi Joshua Beauchemin David Dang Stephen A Lisman J Koji Lum David S Wilson 《Behavioral and brain functions : BBF》2007,3(1):2-14
Background
Research on the genetic basis for impulsivity has revealed an array of ambiguous findings. This may be a result of limitations to self-report assessments of impulsivity. Behavioral measures that assess more narrowly defined aspects of impulsivity may clarify genetic influences. This study examined the relationship between possession of the DRD2 TaqI A and DRD4 48 bp VNTR genetic polymorphisms and performance on a behavioral measure of impulsivity, the delay discounting task (DDT), and three traditional self-report measures. 相似文献653.
L. PIKDÖKEN E. AKCA B. GÜRBÜZER B. AYDIL B. TAŞDELEN 《Journal of oral rehabilitation》2011,38(2):95-100
Summary The aim of this study was to investigate whether cervical wear was associated with occlusal wear and clinical periodontal parameters in relatively older adults. A total of 30 patients, with multiple non‐carious cervical lesions (NCCLs) and without a disease or condition that could cause heavy tooth wear, were included in the study. The periodontal parameters including plaque index, probing pocket depth, gingival recession (GR) and tooth mobility were obtained from 641 teeth of which 475 (74·1%) displayed NCCLs. The levels of cervical wear and occlusal wear were determined according to a tooth wear index. Premolars were more likely to develop cervical wear than canines, molars and incisors. Cervical wear was significantly associated with less plaque accumulation and the presence of shallow pockets. The teeth with advanced GR and without increased mobility were 2·583 and 1·715 times more likely to develop deeper cervical lesions, respectively. Age and the level of occlusal wear were not linked to the bucco‐lingual depth of cervical wear. In conclusion, the significant association of advanced cervical wear with the relatively healthy periodontal status suggested the role of abrasion and its possible combined action with erosion in the aetiology of NCCLs. The rate of GR and the lack of tooth mobility could constitute predisposing factors for the progression of cervical wear because the exposed root surfaces could be more susceptible to abrasion and/or erosion, and the non‐mobile teeth resisting strongly against frictional forces, thus abrasive effects, could possibly develop cervical wear. 相似文献
654.
M.A. Pizzichetta H. Kittler I. Stanganelli G. Ghigliotti M.T. Corradin P. Rubegni S. Cavicchini V. De Giorgi R. Bono M. Alaibac S. Astorino F. Ayala P. Quaglino G. Pellacani G. Argenziano D. Guardoli F. Specchio D. Serraino R. Talamini the Italian Melanoma Intergroup 《The British journal of dermatology》2017,177(2):538-540
655.
目的探讨鼻内镜下多种手术入路治疗上颌窦良性占位性病变的方法及疗效。方法采用鼻内镜下中鼻道扩大上颌窦自然开口术、鼻内镜下中-下鼻道联合上颌窦开窗术、鼻内镜下鼻腔外侧壁切开上颌窦手术、鼻内镜下上颌窦内侧壁切除术、鼻内镜下改良Denker术等多种入路对136例上颌窦良性占位性病变进行手术治疗。结果除2例上颌窦后鼻孔息肉和1例内翻性乳头状瘤复发,经再次手术治疗痊愈外,其他患者均无复发。结论根据上颌窦良性占位性病变的不同临床特点,采用不同手术入路既可有效治愈上颌窦病变,同时可最大限度地减少手术创伤。 相似文献
656.
657.
658.
TA Farnsworth FRCP 《International journal of clinical practice》1998,52(6):445-446
SUMMARY Primary intracranial melanomas are rare and occur mainly in young adults. Originating from leptomeningeal melanoblasts and extending into the parenchyma, the tumours closely resemble meningiomas, from which they are radiologically difficult to distinguish despite progress in neuroimaging. Definitive diagnosis is usually made on histopathological examination, though confirmed only after post-mortem examination in some cases. Prolonged disease-free periods, and in rare cases long-term survival, are possible following successful total surgical excision. This case presented with typical clinical features but, at 79 years old, an unusual age. 相似文献
659.
Giant cell tumors of bone: treatment with radiation therapy 总被引:1,自引:0,他引:1
Records of 15 patients with giant cell tumor of bone treated with radiation therapy over a 35-year period were reviewed; ten patients for whom follow-up information was available constituted the study group. One patient was treated by means of orthovoltage equipment only, a second, by both orthovoltage and megavoltage equipment (cobalt 60). The remaining eight were all treated with megavoltage to doses of 40-52 Gy in 24-30 fractions. Seven patients are alive without disease, with an average survival of 192 months (range, 48-360 months). Three patients died of uncontrolled local and distant disease (average survival, 52 months; range, 23-99 months): one with metastasis in the lungs at time of treatment and two after treatment. Although incidence of lung metastasis appears high, it may be due to patient selection because chemotherapy had failed in all three. Complications from irradiation in one surviving patient required surgical closure of a dural fistula 19 years after treatment. No radiation-induced sarcomatous transformations of controlled tumors were noted. These data suggest that giant cell tumor of bone can be well controlled by radiation therapy. Megavoltage irradiation should be considered in treating local disease not easily controlled by surgery in the axial skeleton. Complications are minimal, and normal function can be preserved in the treated areas. 相似文献
660.
Glaab WE; Risinger JI; Umar A; Barrett JC; Kunkel TA; Tindall KR 《Carcinogenesis》1998,19(11):1931-1937
Although the resistance to the cytotoxic response of certain DNA damaging
agents has been well characterized in cells deficient in mismatch repair,
little is known about how such resistance affects mutagenesis. Using human
cancer cell lines defective in mismatch repair (MMR) and complementary cell
lines in which the MMR defects were corrected by chromosome transfer, we
present the cytotoxic effect and the mutagenic response at the
hypoxanthine-guanine phosphoribosyl transferase (HPRT) locus following
exposure to the chemotherapeutic agent, 6-thioguanine (6-TG). Upon exposure
to 6-TG, there was a differential cytotoxic response. The MMR-deficient
cells were resistant to 6-TG exposure up to 5 microM, whereas the
MMR-proficient cell lines were significantly more sensitive at the same
levels of exposure. Furthermore, the mutagenic response at HPRT induced by
6-TG was substantially increased in the MMR-deficient lines relative to the
MMR- proficient cell lines. These findings support the notion that
cytotoxicity to 6-TG is mediated through functional MMR and that resistance
to the cytotoxic effects of 6-TG is directly associated with an increase in
induced mutations in MMR-defective cells. These data suggest that the use
of 6-TG as a chemotherapeutic agent may result in the selection of
MMR-defective cells, thereby predisposing the patient to an increased risk
for developing secondary tumors.
相似文献