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Noriko Sugawara Tetsuji Morimoto Elnur I. Farajov Naonori Kumagai Ulviyya F. Aslanova Tatemitsu Rai Shinichi Uchida Sei Sasaki Shigeru Tsuchiya Yoshiaki Kondo 《Pflügers Archiv : European journal of physiology》2010,460(1):197-205
The effect of Ca2+ and calcimimetics on NaCl transport was investigated in the in vitro isolated microperfused mouse thin ascending limb of Henle’s loop. In the presence of a transmural NaCl gradient, the transepithelial diffusional potential was 13.7?±?0.4 mV (n?=?17). When the Ca2+ in the bath was increased from 1.5 to 4.5 mM at 37°C, the relative permeability of Na+ to Cl? (P Na /P Cl) estimated from the diffusional voltage deflection due to the transepithelial NaCl gradient (V d) changed from 0.371?±?0.017 to 0.341?±?0.015 (n?=?10, P?<?0.0001). When the Ca2+ in the lumen was increased from 1.5 to 4.5 mM, the P Na /P Cl decreased from 0.349?±?0.013 to 0.330?±?0.013 (n?=?5, P?<?0.002). The addition of 0.1 mM neomycin and 0.2 mM gentamicin to the bath or lumen also decreased the P Na /P Cl. The same effect on P Na /P Cl of Ca2+ and calcimimetics occurred in ClC-K1 (kidney-specific chloride channel) knockout mice. The addition of 300 μg/ml protamine to the bath strongly inhibited changes to P Na /P Cl induced by basolateral Ca2+. These data indicate that ambient Ca2+ and calcimimetics inhibit Na+ transport in the thin ascending limb, which is known to occur via the paracellular shunt pathway. Our observations strongly suggest that Ca2+ is involved in the regulation of paracellular Na+ permeability in the thin ascending limbs. 相似文献
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