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101.
Adolescence spinal epidural abscess with neurological symptoms: case report,a lesson to be re-learnt
Jafar Ganjpour Sales Ali Tabrizi Asghar Elmi Jafar Soleimanpour Ehsan Gavidel 《Medical journal of the Islamic Republic of Iran》2013,27(1):38-41
Epidural abscess of the spinal column is a rare condition that can be fatal if left untreated. It promptly progresses and can cause neurologic paralysis, urinary retention or cauda equina syndrome. Compromised immune system that occurs in patients with diabetes mellitus, AIDS, chronic renal failure, alcoholism, or cancer is a predisposing factor. It mostly occurs in adults. Here we would like to report a case of spontaneous pyogenic lumbar epidural abscess with neurological deficit diagnosed in a 15 year old boy. We treated this case successfully with surgical microscopic decompression and drainage. 相似文献
102.
Tremor is a continuous, repetitive twitching of skeletal muscles, which is usually visible and palpable. Repeated birth of
lambs with neurological disorders in a herd of the region in Northwest of Kerman province of Iran was the reason for careful
examination one of the patients. The 1-day-old lamb with slowly progressive neurologic disturbances consisting of difficulties
in moving and coordination was transferred to the Veterinary Clinic of Shahid Bahonar University of Kerman. The patient suffered
from ataxia and severe tremor. In clinical examination, significant findings were restricted to the nervous system. The animal
was normal in other respects. At necropsy the meningeal blood vessels were congested and occasional small foci of hemorrhage
was seen. Microscopic findings in the brain included ischemic cell change, laminar necrosis, demyelination, diffuse and focal
gliosis, microcavitation, and hemorrhage. Based on the history, clinical, hematological, biochemical, and histopathologic
findings, a severe degenerative process caused the tremor. This is the first report of congenital tremor in an Iranian Fat-Tailed
lamb. 相似文献
103.
G Faghihi† F Iraji† A Shahingohar† AH Saidat‡ 《Journal of the European Academy of Dermatology and Venereology》2008,22(5):531-536
Background Many therapeutic modalities have been suggested for treatment of the chronic hand eczema. Despite good immediate efficacy of some of these treatments, there is high recurrence of the dermatitis following cessation of the treatment. Aim Regarding the beneficial effects of the zinc sulfate on the skin, we designed a double blind study to evaluate the efficacy of the ‘0.05% Clobetasol + 2.5% zinc sulphate’ cream versus ‘0.05% Clobetasol alone’ cream in the treatment of the chronic hand eczema. Subjects and Methods This study was a double‐blind, right to left, prospective, clinical trial. In total, 47 patients with chronic hand eczema admitted to dermatology center of Isfahan University of Medical Sciences were selected and their right hand or left hand were selected at random to be treated with either the ‘0.05% Clobetasol + 2.5% zinc sulphate’ cream or ‘0.05% Clobetasol alone’ cream twice daily for 2 weeks. All of the patients were treated for 2 weeks and were followed up at weeks 2, 4, 6 and 8 after starting the treatment. For determining the severity of chronic hand eczema, we assessed and scored 4 different characteristics of the lesions including redness; scaling; lichenification and pruritus. The data were analyzed using SPSS program (release 13) and statistical tests including Mann‐Whitney test. Results Overall, 47 patients (94 samples) were evaluated. All of these patients had similar and symmetrical lesions on their right and left hands. Out of them, 35 patients were females and 12 patients were male. In all of the evaluated characterisitics, the ‘0.05% Clobetasol + 2.5% zinc sulphate’ cream was more effective than ‘0.05% Clobetasol alone’ cream (P < 0.05). The recurrence rate of eczema was significantly lower in the group treated with this combination treatment (P < 0.05). Conclusion With regard to the encouraging results of the combination treatment with Clobetasol + zinc sulphate, we suggest that in a more extensive clinical trial, the efficacy of this treatment against chronic hand dermatitis be evaluated. In addition, evaluation of this combination therapy against other inflammatory dermatosis seems to be logical. 相似文献
104.
Asghar Davood Ali reza Nematollahi Maryam Iman Abbas Shafiee 《Archives of pharmacal research》2009,32(4):481-487
1,4-Dihydropyridines have been recognized as calcium channel agonist. Three new analogues of Bay K8644 in which the ortho
trifluromethyl phenyl group at position 4 is replaced by the 4-(5)-Chloro-2-ethyl-5-(4)-imidazolyl substituent, were designed
and synthesized as calcium channel agonist. For this propose, the structures of designed compounds were drawn by HYPERCHEM
program. Conformations of the compounds were optimized through semi-empirical method followed by PM3 calculation. Then the
crystalin stucture of L-type calcium channel was obtained from the Protein Data Bank (PDB) server. Docking calculations were
carried out using Auto-Dock.4 program. The good interaction of our 1,4-DHP derivatives showed that they can be as possible
calcium channel agonist agents. Finally compounds were synthesized according to a modified Hantzsch condensation procedure. 相似文献
105.
S G Khasabov J A Lopez-Garcia A U Asghar A E King 《British journal of pharmacology》1999,127(4):843-852
1. The in vitro hemisected spinal cord from young rat was used to investigate the mechanism of serotoninergic modulation of primary afferent-mediated synaptic transmission in the dorsal horn through activation of the 5-HT3 receptor. 2. Dorsal root-evoked excitatory post-synaptic potentials (DR-EPSPs) were recorded intracellularly from dorsal horn neurones. Extracellular recordings of the population primary afferent depolarization (PAD) and the dorsal root-evoked dorsal root reflex (DR-DRR) were made from segmental dorsal roots. 3. 5-Hydroxytryptamine (5-HT) and the selective 5-HT3 receptor agonist 1-(m-chloro-phenyl)-biguanide hydrochloride (m-ChPB) (10 and 50 microM) induced statistically significant reductions of the DR-EPSP amplitude (P<0.001) and duration (P<0.001) in the majority of dorsal horn neurones. The 5-HT3 receptor selective antagonists 3-Tropanyl-indole-3-carboxylate hydrochloride (Tropisetron, 10 microM) and N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1 ,4-benzoxazine-8-carboxamide (Y-25130, 10 microM) abolished m-ChPB-induced DR-EPSP attenuation and partially blocked the 5-HT effect. 4. m-ChPB (50 microM)-induced DR-EPSP amplitude and duration attenuation was retained in the presence of the GABA(A) receptor antagonist bicuculline (30 microM), the GABA(B) receptor antagonist saclofen (50 microM) and the opioid receptor antagonist naloxone (50 microM). 5. Both 5-HT and m-ChPB (10 and 50 microM) induced a PAD but the mean peak amplitude of 5-HT-induced PAD was significantly greater than PAD to m-ChPB (98.6+/-12 microV compared to 51.8+/-10 V for 50 microM of agonist, respectively). Tropisetron partially reduced 5-HT-induced PAD and abolished m-ChPB-induced PAD. 5-HT, but not m-ChPB, significantly (P<0.001) reduced the peak amplitude of the DR-DRR and this action of 5-HT was unaffected by Tropisetron or Y-25130. 6. These data provide experimental evidence for a putative cellular mechanism at the level of the dorsal horn for anti-nociceptive effects of 5-HT3 receptor activation. This 5-HT3-mediated modulation of sensory afferent transmission was evidently independent of inhibitory GABA- or opioid-dependent interneuronal pathways. The extent to which the 5-HT3 receptor could be involved in the operation of endogenous analgesia and sensory modulation by descending monoamine bulbo-spinal pathways is discussed. 相似文献
106.
107.
108.
Liu J Zheng BS Aposhian HV Zhou YS Chen ML Zhang AH Waalkes MP. 《Journal of the peripheral nervous system : JPNS》2002,7(3):208-208
Optimization of a previously disclosed sorbitol dehydrogenase inhibitor (SDI, II) for potency and duration of action was achieved by replacing the metabolically labile N,N-dimethylsulfamoyl group with a variety of heterocycles. Specifically, this effort led to a series of novel, in vitro potent SDIs with longer serum half-lives and acceptable in vivo activity in acutely diabetic rats (e.g., 62, 67, and 69). However, the desired in vivo potency in chronically diabetic rats, ED90 less than or equal to 5 mg/kg/day, was achieved only through further modification of the piperazine linker. Several members of this family, including 86, showed better than the targeted potency with ED90 values of 1-2 mg/kg/day. Compound 86 was further profiled and found to be a selective inhibitor of sorbitol dehydrogenase, with excellent pharmacodynamic/pharmacokinetic properties, demonstrating normalization of sciatic nerve fructose in a chronically diabetic rat model for approximately 17 h, when administered orally at a single dose of 2 mg/kg/day. 相似文献
109.
110.
A Kavak† N Yeildal†† AH Parlak‡ G Gökdemir§ Aydoan† H Anul† C Baykal¶ 《Journal of the European Academy of Dermatology and Venereology》2008,22(8):977-981
Background Alopecia areata is a complex genetic disease with still many unknown aspects, and many studies have been tried to find some clues about it.
Objective We aimed to investigate the demographic and clinical characteristics of alopecia areata in Turkish patients.
Methods Demographic data, localization, attack number in addition to some parameters such as disease duration, severity, age of onset, family history and ophiasis pattern were evaluated in 539 alopecia areata patients.
Results The male to female ratio was 1.6 : 1. Occipital and beard-moustache areas were mostly affected. Positive family history was noticed in 24.1% of the patients. The age of onset was earlier in women than in men ( P = 0.04). Severe forms showed more persistent (≥ 1 year) disease duration ( P = 0.00). Ophiasis was more common in severe, long duration (≥ 1 year) and early onset (≤ 18 years) disease ( P = 0.00 for all parameters). Childhood alopecia areata (≤ 18 years) was also associated with long duration of the disease ( P = 0.016) and positive family history ( P = 0.008) when compared with adult onset (> 18 years) alopecia areata. 相似文献
Objective We aimed to investigate the demographic and clinical characteristics of alopecia areata in Turkish patients.
Methods Demographic data, localization, attack number in addition to some parameters such as disease duration, severity, age of onset, family history and ophiasis pattern were evaluated in 539 alopecia areata patients.
Results The male to female ratio was 1.6 : 1. Occipital and beard-moustache areas were mostly affected. Positive family history was noticed in 24.1% of the patients. The age of onset was earlier in women than in men ( P = 0.04). Severe forms showed more persistent (≥ 1 year) disease duration ( P = 0.00). Ophiasis was more common in severe, long duration (≥ 1 year) and early onset (≤ 18 years) disease ( P = 0.00 for all parameters). Childhood alopecia areata (≤ 18 years) was also associated with long duration of the disease ( P = 0.016) and positive family history ( P = 0.008) when compared with adult onset (> 18 years) alopecia areata. 相似文献