全文获取类型
收费全文 | 3068篇 |
免费 | 204篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 40篇 |
儿科学 | 72篇 |
妇产科学 | 70篇 |
基础医学 | 527篇 |
口腔科学 | 59篇 |
临床医学 | 280篇 |
内科学 | 824篇 |
皮肤病学 | 42篇 |
神经病学 | 275篇 |
特种医学 | 120篇 |
外科学 | 304篇 |
综合类 | 36篇 |
一般理论 | 1篇 |
预防医学 | 231篇 |
眼科学 | 85篇 |
药学 | 156篇 |
中国医学 | 9篇 |
肿瘤学 | 161篇 |
出版年
2024年 | 6篇 |
2023年 | 25篇 |
2022年 | 72篇 |
2021年 | 93篇 |
2020年 | 52篇 |
2019年 | 75篇 |
2018年 | 79篇 |
2017年 | 53篇 |
2016年 | 78篇 |
2015年 | 101篇 |
2014年 | 146篇 |
2013年 | 141篇 |
2012年 | 221篇 |
2011年 | 249篇 |
2010年 | 137篇 |
2009年 | 127篇 |
2008年 | 190篇 |
2007年 | 218篇 |
2006年 | 194篇 |
2005年 | 203篇 |
2004年 | 197篇 |
2003年 | 183篇 |
2002年 | 150篇 |
2001年 | 18篇 |
2000年 | 10篇 |
1999年 | 32篇 |
1998年 | 37篇 |
1997年 | 31篇 |
1996年 | 20篇 |
1995年 | 18篇 |
1994年 | 16篇 |
1993年 | 13篇 |
1992年 | 9篇 |
1991年 | 3篇 |
1990年 | 7篇 |
1989年 | 4篇 |
1988年 | 7篇 |
1987年 | 3篇 |
1985年 | 6篇 |
1984年 | 5篇 |
1983年 | 7篇 |
1981年 | 7篇 |
1976年 | 4篇 |
1975年 | 7篇 |
1973年 | 3篇 |
1971年 | 5篇 |
1970年 | 2篇 |
1962年 | 2篇 |
1936年 | 2篇 |
1909年 | 2篇 |
排序方式: 共有3292条查询结果,搜索用时 15 毫秒
81.
Arturo Ciccullo Gianmaria Baldin Vanni Borghi Filippo Lagi Alessandra Latini Gabriella dEttorre Letizia Oreni Paolo Fusco Amedeo Capetti Massimiliano Fabbiani Andrea Giacomelli Alessandro Grimaldi Giordano Madeddu Gaetana Sterrantino Cristina Mussini Simona Di Giambenedetto 《Viruses》2022,14(1)
Dolutegravir (DTG) is currently one of the most used Integrase inhibitors (INI) in antiretroviral therapies (ARV) in both naïve and experienced people living with HIV (PLWHIV). We analyzed a multicenter cohort of PLWHIV, both naïve and experienced, starting an ARV including DTG. We enrolled 3775 PLWHIV: 2763 (73.2%) were males, with a median age of 50 years. During 9890.7 PYFU, we observed 930 discontinuations (9.4 per 100 PYFU). Estimated probabilities of maintaining DTG at three and five years were 75.1% and 67.2%, respectively. Treatment-naïve pts showed a lower probability of maintaining DTG at three and five years compared to treatment-experienced PLWHIV (log-rank p < 0.001). At a multivariate analysis, a longer time of virological suppression (aHR 0.994, p < 0.001) and having experienced a previous virological failure (aHR 0.788, p = 0.016) resulted protective against DTG discontinuation. Most discontinuations (84.0%) happened within the first 12 months of DTG initiation, in particular, 92.2% of discontinuations due to neuropsychiatric toxicity were observed in the first year. Our data confirm the overall good tolerability of DTG in clinical practice, with a low rate of discontinuations. CNS toxicity resulted the main reason for DTG discontinuation, with most related interruptions happening in the first year from DTG introduction. 相似文献
82.
Claudia Ojeda-Granados Martina Barchitta Maria Clara La Rosa Claudia La Mastra Sonia Roman Arturo Panduro Antonella Agodi Andrea Maugeri 《Nutrients》2022,14(8)
Traditional diets are known to be beneficial; however, both Italian and Mexican populations are gradually moving away from the Mediterranean and traditional Mexican diets. Since women play a key role in safeguarding dietary traditions and may reflect population dietary changes, we aimed to identify Italian and Mexican women’s current dietary patterns (DPs) and characterize their nutrient content. Cross-sectional analyses were separately conducted on two convenience samples of 811 women from Southern Italy and 215 women from Western Mexico. Food frequency questionnaires, 24 h recalls, and a principal component analysis (PCA) approach were used to derive a posteriori DPs. In Italian women, the first DP was characterized by the consumption of legumes, vegetables, and fish (8.8% of the total variance), while the second DP was characterized by snack foods, processed meats, and non-olive oils. In Mexican women, the first DP was characterized by the consumption of meats and processed foods (12.6% of the total variance), while the second DP by fruits, vegetables, and whole grains. In both populations, adhering to the DPs rich in healthy foods (i.e., fruits, vegetables, legumes, and fish) was associated with a higher quality of diet in terms on nutrient content. However, adherence to the Western-type DPs was more common among women of younger age (p < 0.035). Thus, more extraordinary efforts are needed in promoting each country’s traditional healthy diet, especially among the new generations. 相似文献
83.
Rody El Nawar Bertrand Lapergue Michel Piotin Benjamin Gory Raphael Blanc Arturo Consoli Georges Rodesch Mikael Mazighi Frederic Bourdain Maéva Kyheng Julien Labreuche Fernando Pico 《JACC: Cardiovascular Interventions》2019,12(4):385-391
Objectives
The aim of this study was to determine whether individual operator characteristics have an impact on reperfusion and procedural complication rates.Background
Mechanical thrombectomy (MT) is a Level IA treatment in acute ischemic stroke (AIS) patients. The operator’s effect has been found to be an independent predictor for clinical outcome and technical performance in interventional cardiology.Methods
From the ETIS (Endovascular Treatment in Ischemic Stroke) study, a prospective, multicenter, observational real-world MT registry, the authors included all AIS patients consecutively treated by MT between January 2012 and March 2017 in 3 high-volume comprehensive stroke centers by 19 operators. We assessed the effect of individual operator characteristics on successful reperfusion, defined as modified Thrombolysis In Cerebral Infarction 2b/3 at the end of MT, and procedural complications using multivariable hierarchical logistic regression models.Results
A total of 1,541 patients with anterior and posterior AIS were enrolled (mean age 67 years; median NIHSS 16). There was a significant operator effect on successful reperfusion, with an intraclass correlation coefficient of 0.036 (p = 0.046), but not on complications (intraclass correlation coefficient = 0). There was a dose–response relationship between annual operator volume and successful reperfusion rate (p = 0.003) with an adjusted odds ratio for successful reperfusion equal to 2.52 (95% confidence interval: 1.37 to 4.64) for patients treated by an operator with an annual volume ≥40 MT/year compared with those treated by an operator with <14 MT/year (first tertile). Nevertheless, this result did not translate to better clinical outcomes.Conclusions
Our data suggest that operator volume of MT/year has a positive impact on successful reperfusion in AIS patients, but not on clinical outcomes nor on complication rates. Further studies are warranted to investigate threshold procedure numbers associated with better outcomes. 相似文献84.
Valencia-Flores M Orea A Herrera M Santiago V Rebollar V Castaño VA Oseguera J Pedroza J Sumano J Resendiz M García-Ramos G 《Obesity surgery》2004,14(6):755-762
Background: We evaluated the impact of surgically-induced weight loss on Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS),
electrocardiographic changes, pulmonary arterial pressure and daytime sleepiness in morbidly obese patients. Methods: 16 women
and 13 men (n=29) underwent bariatric surgery in a 3-year period. The following tests were performed before and 1 year after
surgery: nocturnal polysomnography, daytime Multiple Sleep Latency Test (MSLT), and echocardiogram. Results: Mean age was
37.9±11 years (range 20-56). Preoperative body mass index was 56.5±12.3 kg/m2 and it was 39.2±8.5 kg/m2 at 13.7±6.6 months follow-up. Performed surgical procedures included: vertical banded gastroplasty in 6, Roux-en-Y gastric
bypass in 12, and Distal Roux-en-Y gastric bypass in 11. Weight loss induced by surgery eliminated OSAHS in 46% of obese patients
with an important improvement in oxygen saturation. Neck, thorax, waist and hip circumferences decreased significantly after
surgical intervention but only neck circumference correlated significantly with the apnea/hypopnea index (Spearman rho=0.63, P <0.0001). Electrocardiographic abnormalities were present in 9 patients (31%) before surgery (sinus arrhythmia, ventricular
arrhythmias, and sinus arrest). The number of electrocardiographic abnormalities decreased after surgery but new abnormalities
appeared in some patients. Systolic pulmonary arterial pressure significantly decreased in the group of patients in whom OSAHS
disappeared after surgery. Daytime sleepiness persisted after surgery in most patients. Conclusion: Bariatric surgery effectively
reduces respiratory disturbances during sleep and improves pulmonary hypertension. Electro cardiographic abnormalities change
after surgery. Daytime sleepiness appeared not to be related to respiratory disturbances during sleep. 相似文献
85.
86.
87.
88.
89.
Raul A. Bastarrachea MD Juan C. López-Alvarenga MD PhD Raúl Calzada-León MD Sara Arellano-Montaño MD Jorge Gonzalez-Barranco MD Rafael Violante-Ortíz MD Blanca Estela Del-Rio-Navarro MD Agustín Lara-Esqueda MD Pedro Pérez MD Guillermo Fanghänel MD Agustín Madero MD Arturo Berber MD PhD 《Advances in therapy》2006,23(3):506-509
90.