全文获取类型
收费全文 | 1184篇 |
免费 | 58篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 50篇 |
妇产科学 | 44篇 |
基础医学 | 162篇 |
口腔科学 | 17篇 |
临床医学 | 119篇 |
内科学 | 208篇 |
皮肤病学 | 32篇 |
神经病学 | 115篇 |
特种医学 | 131篇 |
外科学 | 77篇 |
综合类 | 37篇 |
预防医学 | 89篇 |
眼科学 | 5篇 |
药学 | 71篇 |
1篇 | |
中国医学 | 6篇 |
肿瘤学 | 60篇 |
出版年
2023年 | 5篇 |
2022年 | 6篇 |
2021年 | 12篇 |
2020年 | 10篇 |
2019年 | 10篇 |
2018年 | 20篇 |
2017年 | 11篇 |
2016年 | 16篇 |
2015年 | 20篇 |
2014年 | 25篇 |
2013年 | 42篇 |
2012年 | 32篇 |
2011年 | 54篇 |
2010年 | 51篇 |
2009年 | 56篇 |
2008年 | 42篇 |
2007年 | 50篇 |
2006年 | 55篇 |
2005年 | 52篇 |
2004年 | 38篇 |
2003年 | 26篇 |
2002年 | 36篇 |
2001年 | 26篇 |
2000年 | 24篇 |
1999年 | 24篇 |
1998年 | 45篇 |
1997年 | 50篇 |
1996年 | 46篇 |
1995年 | 23篇 |
1994年 | 33篇 |
1993年 | 29篇 |
1992年 | 21篇 |
1991年 | 19篇 |
1990年 | 20篇 |
1989年 | 27篇 |
1988年 | 37篇 |
1987年 | 19篇 |
1986年 | 18篇 |
1985年 | 16篇 |
1984年 | 21篇 |
1983年 | 18篇 |
1982年 | 15篇 |
1981年 | 15篇 |
1980年 | 7篇 |
1979年 | 4篇 |
1978年 | 5篇 |
1977年 | 3篇 |
1976年 | 4篇 |
1972年 | 2篇 |
1925年 | 2篇 |
排序方式: 共有1247条查询结果,搜索用时 15 毫秒
91.
A Choppin I Irwin L Lach MG McDonald AE Rettie L Shao C Becker MP Palme X Paliard S Bowersox DM Dennis P Druzgala 《British journal of pharmacology》2009,158(6):1536-1547
Background and purpose:
Tecarfarin (ATI-5923) is a novel vitamin K epoxide reductase inhibitor that is metabolized by esterase (mainly human carboxylesterase 2) to a single major metabolite, ATI-5900, in rats, dogs and humans. Tecarfarin is not significantly metabolized by CYP450 enzymes. The objective of this study was to test and compare the efficacy of tecarfarin with that of warfarin, when administered either intravenously or once a day orally, to produce stable anticoagulation in beagle dogs.Experimental approach:
Effects on coagulation were assessed by measuring the activity levels of Factor VII and Factor X and thromboplastin-induced coagulation times, reported as prothrombin time (PT).Key results:
Continuous intravenous infusions and oral administration of tecarfarin and warfarin caused a dose-dependent decrease in activity of Factor VII and Factor X, and associated increase in PT. Intravenous fresh frozen canine plasma or subcutaneous vitamin K1 treatment reversed the anticoagulant effects of orally administered tecarfarin. Consistent with the inhibitory effects of amiodarone on CYP2C9, co-administration of amiodarone significantly increased the anticoagulation effect of warfarin and plasma warfarin concentrations. In contrast, amiodarone had no effect on the anticoagulation induced by tecarfarin or tecarfarin plasma concentrations in this model.Conclusions and implications:
Overall, the data presented herein indicate that tecarfarin, via a vitamin K-dependent mechanism, causes changes in key parameters of haemostasis in beagle dogs that are consistent with effective anticoagulation. Compared to warfarin it has a decreased potential to interact metabolically with drugs that inhibit CYP450 enzymes and, therefore, may offer an improved safety profile for patients. 相似文献92.
93.
94.
95.
Development of the Manchester framework for the evaluation of emergency department pharmacy services
Greenwood D Tully MP Martin S Steinke D 《International journal of clinical pharmacy》2022,44(4):930-938
International Journal of Clinical Pharmacy - Many countries, including the United Kingdom, have established Emergency Department (ED) pharmacy services where some ED pharmacists now work as... 相似文献
96.
Carpay JA Vermeulen J Stroink H Brouwer OF Boudewyn Peters AC Aldenkamp AP van Donselaar CA Arts WF 《Epilepsy & behavior : E&B》2002,3(4):322-329
We used a parent-completed 20-item "side effect scale" quantifying complaints that parents perceive to be caused by antiepileptic drugs (AEDs) in 108 children with active epilepsy. We studied the associations between parent-reported complaints, severity of seizures, and restrictions due to epilepsy, and clinical data including number and AED load. In 85% of the children at least one complaint was reported, in less than 20% complaints were perceived as a substantial problem. In a multivariate analysis, there was no significant relationship between the "side effect scale" score and AED load, or the number of AEDs. However, complaints were associated with parent-reported frequency and severity of seizures. We conclude that the adverse effects of seizures or parental concern about the severity and intractability of seizures in their children may have influenced the reported complaints. 相似文献
97.
Treatment of vitiligo with topical imiquimod 总被引:1,自引:0,他引:1
98.
Muscle ultrasound is a useful tool in the diagnosis of neuromuscular disorders, as these disorders result in muscle atrophy and intramuscular fibrosis and fatty infiltration, which can be visualized with ultrasound. Several prospective studies have reported high sensitivities and specificities in the detection of neuromuscular disorders. Although not investigated in large series of patients, different neuromuscular disorders tend to show specific changes on muscle ultrasound, which can be helpful in differential diagnosis. For example, Duchenne muscular dystrophy results in a severe, homogeneous increase of muscle echo intensity with normal muscle thickness, whereas spinal muscular atrophy shows an inhomogeneous increase of echo intensity with severe atrophy. A major advantage of muscle ultrasound, compared to other imaging techniques, is its ability to visualize muscle movements, such as muscle contractions and fasciculations. This study reviews the possibilities and limitations of ultrasound in muscle imaging and its value as a diagnostic tool in neuromuscular disorders. 相似文献
99.
T Canedo MP De Almeida T Cuzzi M Ramos‐e‐Silva 《Journal of the European Academy of Dermatology and Venereology》2010,24(2):178-185
Background Some adnexal tumours have many controversies about their histogenesis. Objectives To evaluate the eccrine and/or apocrine differentiation phenotype in cases of cylindroma and clear cell hidradenoma with CD15 and p63 antibodies. Methodology Slides and blocks of six cases of cylindroma and seven cases of nodular hidradenoma (clear cells) were analyzed by the technique of immunohistochemistry with CD15 and p63 antibodies. Results In all cases of cylindroma we obtained negative results for CD15 antibody and positive for p63 antibody. In five of seven cases of nodular hidradenoma (clear cell), we could easily observe clear cells between 20% and 50% of tumour cells. In the two other cases, cystic lesions were present and occasional clear cells could be seen. The reaction with CD15 antibody was positive in granular and cytoplasmic pattern in six of seven cases, especially in cells with suggestive clear cytoplasm in lower proportion than this clear cells could be seen in haematoxylin and eosin. The positivity for p63 antibody, nuclear pattern, was observed in six of seven cases, in the major part of tumour cells. In only one case, the positivity was in 20% of cells. Limitation Samples are in small number because these are relatively rare tumours. Conclusions The present study suggests eccrine origin for both tumours: cylindroma and clear cell hidradenoma. 相似文献
100.