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排序方式: 共有4752条查询结果,搜索用时 31 毫秒
101.
Weidner Kathrin Behnes Michael Schupp Tobias Hoppner Jorge Ansari Uzair Mueller Julian Lindner Simon Borggrefe Martin Kim Seung-hyun Huseyinov Aydin Ellguth Dominik Akin Muharrem Meininghaus Dirk Große Bertsch Thomas Taton Gabriel Bollow Armin Reichelt Thomas Engelke Niko Reiser Linda Akin Ibrahim 《Journal of interventional cardiac electrophysiology》2022,63(1):13-20
Journal of Interventional Cardiac Electrophysiology - The study sought to assess the prognostic impact of chronic kidney disease (CKD) in patients with electrical storm (ES). ES represents a... 相似文献
102.
C. Madl W. Hasibeder P. Lechleitner K. Lenz K. H. Lindner W. Oder G. Prause E. Rumpl E. Schmutzhard F. Sterz 《Intensivmedizin und Notfallmedizin》2002,13(1):117-124
In den letzten Jahren wurden zahlreiche Prognoseparameter zur Beurteilung der cerebralen Hypoxie nach kardiopulmonaler Reanimation untersucht. Diese Parameter umfassen neben klinischen Daten und klinischen Scoresystemen, verschiedene klinisch-neurologische Befunde, biochemische Parameter, elektrophysiologische Untersuchungen und neurodiagnostische bildgebende Verfahren. Ziel der ?sterreichischen interdisziplin?ren Konsensuskonferenz war die kritische Evaluierung dieser Parameter und die Empfehlung welche Parameter bzw. diagnostischen Ma?nahmen zu welchem Zeitpunkt eine prognostische Aussage über eine potentielle neurologische Rehabilitation nach cerebraler Hypoxie erm?glichen. Aus mehr als 100 unterschiedlichen Parametern wurden 26 Parameter identifiziert, die, basierend auf Ergebnisse wissenschaftlicher Publikationen, eine prognostische Aussage erm?glichen. Diese Parameter müssen jedoch hinsichtlich der Einsch?tzung der Evidenz und deren St?rkegrad als Grundlage für prognostische Empfehlungen unterschiedlich beurteilt werden. 相似文献
103.
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Preliminary observation with dronabinol in patients with intractable pruritus secondary to cholestatic liver disease 总被引:5,自引:0,他引:5
Neff GW O'Brien CB Reddy KR Bergasa NV Regev A Molina E Amaro R Rodriguez MJ Chase V Jeffers L Schiff E 《The American journal of gastroenterology》2002,97(8):2117-2119
Pruritus due to cholestatic liver disease can be particularly difficult to manage and frequently is intractable to a variety of medical therapies. The aim of our study is to evaluate the efficacy of delta-9-tetrahydrocannabinol (delta-9-THC) for intractable cholestatic related pruritus (ICRP) that has failed conventional (and unconventional) remedies. Three patients were evaluated for plasmapheresis because of ICRP. All 3 patients had previously been extensively treated with standard therapies for ICRP including: diphenhydramine, chlorpheniramine, cholestyramine, rifampicin, phenobarbital, doxepin, naltrexone, UV therapy, and topical lotions. Even multiple courses of plasmapheresis were performed without any benefit for the intractable pruritus. All patients reported significant decreases in their quality of life, including lack of sleep, depression, inability to work, and suicidal ideations. All patients were started on 5 mg of delta-9-THC (Marinol) at bedtime. All 3 patients reported a decrease in pruritus, marked improvement in sleep, and eventually were able to return to work. Resolution of depression occurred in two of three. Side effects related to the drug include one patient experiencing a disturbance in coordination. Marinol dosage was decreased to 2.5 mg in this patient with resolution of symptoms. The duration of antipruritic effect is approximately 4-6 hrs in all three patients suggesting the need for more frequent dosing. Delta-9-tetrahydrocannabinol may be an effective alternative in patients with intractable cholestatic pruritus. 相似文献
105.
106.
Advances in myocardial perfusion imaging have firmly established the use of noninvasive techniques capable of providing useful
information over a broad range of diagnostic and therapeutic cardiovascular problems. Evaluating regional myocardial perfusion
abnormalities is a cornerstone for the diagnosis of coronary artery disease, risk assessment in those with known disease,
and determination of myocardial viability. The clinical use of myocardial perfusion imaging and the current limitations of
existing techniques continue to promote the development of new technologies capable of assessing microvascular and capillary
perfusion abnormalities on a global myocardial level. Myocardial contrast echocardiography is an emerging technique capable
of rapidly assessing myocardial perfusion at the capillary level in many different clinical settings. This article focuses
on myocardial contrast-enhanced ultrasound perfusion techniques, emphasizing the unique information this modality provides
compared with other noninvasive perfusion imaging techniques. 相似文献
107.
Eder L Zisman D Barzilai M Laor A Rahat M Rozenbaum M Bitterman H Feld J Rimar D Rosner I 《The Journal of rheumatology》2008,35(5):877-882
OBJECTIVE: To investigate the prevalence of subclinical atherosclerosis among patients with psoriatic arthritis (PsA). METHODS: Forty patients with PsA were enrolled. Controls were matched by age, sex, and atherosclerotic risk factors. All patients and controls underwent duplex scan of the carotid arteries. Carotid intima-media thickness (IMT) was evaluated and the presence of atherosclerotic plaques was recorded. The plaques were graded and carotid plaque index was calculated. RESULTS: Patients with PsA had a higher IMT (mean +/- standard deviation, 1.04 +/- 0.35 mm vs 0.88 +/- 0.29 mm in controls; p = 0.03), and had a higher carotid plaque index than did matched controls (2.3 +/- 2.6, compared to 1.12 +/- 2.09; p = 0.03). Multivariate analysis demonstrated that PsA status as well as age and triglyceride levels were associated with the presence of carotid plaque. Other traditional risk factors were more prevalent among patients with PsA; however, they were not statistically significant. CONCLUSION: Our study demonstrates that patients with PsA may have an increased prevalence of subclinical atherosclerosis. These findings may not be solely attributable to traditional risk factors alone. Special attention and strict control of atherosclerotic risk factors in patients with PsA is warranted. 相似文献
108.
109.
Exogenous neopterin causes cardiac contractile dysfunction in the isolated perfused rat heart 总被引:2,自引:0,他引:2
Margreiter J Schlager A Balogh A Maier H Balogh D Lindner KH Fuchs D Schobersberger W 《Journal of molecular and cellular cardiology》2000,32(7):1265-1274
Neopterin is known in humans as a sensitive marker for diseases associated with increased activity of the cellular immune system. Recent studies report neopterin also to exhibit distinct effects: neopterin induces inducible nitric oxide synthase expression in rat vascular smooth muscle cells and activates translocation of nuclear factor- kappa B. Neopterin may also induce oxidative stress causing apoptotic cell death, or superinduce tumor necrosis factor- alpha -mediated apoptosis. Observing these effects in cell cultures, we were interested in possible consequences of neopterin on cardiac function in the isolated perfused rat heart. The influence of neopterin in three different concentrations (10 micromol/l, 50 micromol/l, 100 micromol/l) on cardiac contractility parameters and coronary vascular resistance were studied in 67 male Sprague-Dawley rats using the temperature-controlled and pressure-constant Langendorff apparatus with retrograde perfusion of the aorta with a Krebs-Henseleit buffer. Treatment with 100 micromol/l neopterin resulted in a significant decrease in coronary flow and cardiac contractility. Coronary flow decreased from 15.2 to 9.5 ml/min (P=0.002), left ventricular pressure from 80 to 52 mmHg (P=0. 002), rate of pressure fall from 1605 to 923 mmHg/s (P=0.001) and rate of pressure rise from 2862 to 1709 mmHg/s (P=0.001). Concentrations lower than 100 micromol/l neopterin had no significant effect on cardiac function. Our study demonstrates a considerable influence of exogenous neopterin on cardiac performance in the Langendorff model of isolated perfused rat hearts. This has to be considered a potential pathogenic factor of cardiac disturbances in diseases in which high concentrations of neopterin are released due to immune activation. At present the exact mechanism remains unclear. 相似文献
110.