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排序方式: 共有392条查询结果,搜索用时 15 毫秒
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Long-term follow-up of autoantibody profiles in black female lupus patients and clinical comparison with Caucasian and Asian patients 总被引:5,自引:4,他引:1
The aim was to determine whether the autoantibody profile in Black female
lupus patients is associated with clinical subsets, fluctuates over time
and/or reflects disease activity. A clinical comparison with Caucasian and
Asian patients matched for age of onset and disease duration was also
undertaken. Up to seven serial bleeds from Black female lupus patients who
had been followed up for periods of 3.15 yr were tested for antibodies to
Ro/SSA, La SSB. Sm, RNP and ribosomal P using ELISA research assays.
Significant differences in both clinical and serological profiles between
the ethnic groups were found. Varying aspects of disease activity were
linked to anti-DNA (renal, cardiovascular, global score), anti-ribosomal P
(musculoskeletal, haematology) and anti-Sm (general) antibodies. There are
differences in clinical and serological profiles amongst systemic lupus
erythematosus patients of different ethnic origin. However, using the BILAG
system, relatively few antibodies were found to reflect disease activity
accurately in serial measurements.
相似文献
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Michael Ardagh 《Emergency medicine Australasia : EMA》1995,7(4):225-228
A 49 year old man with hypertrophic cardiomyopathy and atrial fibrillation presented with bilateral lower limb ischaemia due to embolism of a left ventricular mural thrombus causing occlusion of the distal aorta and common iliac arteries. The patient developed severe pulmonary oedema. This was thought to be caused by the elevated cardiac after-load imposed by the aortic obstruction. He was successfully treated with continuous positive airway pressure prior to definitive treatment of the obstruction by bilateral aorto-iliac embolectomies. 相似文献
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Matson GB; Twieg DB; Karczmar GS; Lawry TJ; Gober JR; Valenza M; Boska MD; Weiner MW 《Radiology》1988,169(2):541-547
Localized phosphorus-31 magnetic resonance (MR) spectroscopy in humans has previously been accomplished with surface coils by means of depth-resolved surface coil spectroscopy or rotating frame experiments, in which the extent of tissue sampled critically depends on surface coil placement. The authors' goal was to modify the surface coil image-selected in vivo spectroscopy (ISIS) experiment to accomplish three-dimensional volume selection through application of selective pulses in the presence of B0 gradients. Advantages of ISIS include the ability to use proton images to define the volume of interest (VOI) and reduced dependence on exact positioning of the surface coil. However, rapid replication of the surface coil ISIS experiment can cause spectral contamination from signals originating outside the VOI. A modified version of the ISIS experiment was developed to alleviate contamination under conditions of rapid replication. Applications of localized P-31 MR spectroscopy for observation of high-energy phosphorus metabolites are presented in human liver, heart, and transplanted and normal kidney. 相似文献
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Heitger MH Jones RD Dalrymple-Alford JC Frampton CM Ardagh MW Anderson TJ 《Brain injury : [BI]》2006,20(8):807-824
Objective: This study examined motor impairments over 1 year following mild closed head injury (CHI). It is the first study to serially assess long-term oculomotor and upper-limb visuomotor function following mild head trauma.
Methods: Thirty-seven patients with mild CHI and 37 matched controls were compared at 1 week, 3 months and 6 months and 31 available pairs at 12 months post-injury on measures of saccades, oculomotor smooth pursuit, upper-limb visuomotor function and neuropsychological performance. Symptomatic recovery was sampled using the Rivermead Postconcussion Symptoms Questionnaire.
Results: At 1 week, the group with CHI reported high levels of post-concussional symptoms and exhibited prolonged saccade latencies, increased directional errors, decreased saccade accuracy and impaired fast sinusoidal smooth pursuit concomitant with increased arm movement reaction time, decreased arm movement speed and decreased motor accuracy on upper-limb visuomotor tracking tasks. Neuropsychological testing identified deficits only in verbal learning and speed of processing while attention, short-term/working memory and general cognitive performance were preserved. At 3 and 6 months, the group with CHI continued to show deficits on several oculomotor and upper-limb visuomotor measures in combination with some deficits on verbal learning and improved, yet abnormal, levels of post-concussional symptoms. At 12 months, the group with CHI had no cognitive impairment but residual deficits in eye and arm motor function and continued to show elevated levels of post-concussional symptoms.
Conclusions: The findings indicate that multiple motor systems are measurably impaired up to 12 months following mild CHI and that instrumented motor assessment may provide sensitive and objective markers of cerebral dysfunction during recovery from mild head trauma independent of neuropsychological assessment and patient self-report. 相似文献
Methods: Thirty-seven patients with mild CHI and 37 matched controls were compared at 1 week, 3 months and 6 months and 31 available pairs at 12 months post-injury on measures of saccades, oculomotor smooth pursuit, upper-limb visuomotor function and neuropsychological performance. Symptomatic recovery was sampled using the Rivermead Postconcussion Symptoms Questionnaire.
Results: At 1 week, the group with CHI reported high levels of post-concussional symptoms and exhibited prolonged saccade latencies, increased directional errors, decreased saccade accuracy and impaired fast sinusoidal smooth pursuit concomitant with increased arm movement reaction time, decreased arm movement speed and decreased motor accuracy on upper-limb visuomotor tracking tasks. Neuropsychological testing identified deficits only in verbal learning and speed of processing while attention, short-term/working memory and general cognitive performance were preserved. At 3 and 6 months, the group with CHI continued to show deficits on several oculomotor and upper-limb visuomotor measures in combination with some deficits on verbal learning and improved, yet abnormal, levels of post-concussional symptoms. At 12 months, the group with CHI had no cognitive impairment but residual deficits in eye and arm motor function and continued to show elevated levels of post-concussional symptoms.
Conclusions: The findings indicate that multiple motor systems are measurably impaired up to 12 months following mild CHI and that instrumented motor assessment may provide sensitive and objective markers of cerebral dysfunction during recovery from mild head trauma independent of neuropsychological assessment and patient self-report. 相似文献
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