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排序方式: 共有392条查询结果,搜索用时 15 毫秒
131.
RW Pitcher-Wilmott RJ Levinsky I Gordon MW Turner DJ Matthew 《Archives of disease in childhood》1982,57(8):582-586
The clinical significance of the high prevalence of positive immediate skin tests in cystic fibrosis is unclear. Using analysis of variance, we have tested the hypothesis that patients with allergic cystic fibrosis have worse lung disease than non-allergic patients. Clinical data, skin prick tests, total or specific IgE antibody levels, chest radiographs, and pulmonary function tests were obtained in 104 cystic fibrosis patients. Patients with positive immediate skin reactions to at least one allergen were more likely to be persistently colonised by Pseudomonas aeruginosa than skin test negative patients. The skin test positive patients were also significantly older (mean difference 2.15 years). Analysis of variance showed that pseudomonas infection was the most significant factor contributing to lung damage and the effect of allergy was not significant. Similar longitudinal analysis of pulmonary function over 5 years and study of the hospital admission rate showed that the only statistically significant factor associated with deterioration was colonisation with P. aeruginosa. 相似文献
132.
Changing patterns of blood transfusions in four sets of United States hospitals, 1980 to 1985 总被引:1,自引:0,他引:1
Annual transfusion activity between 1980 and 1985 was surveyed in four sets of United States (US) hospitals, which together accounted for 4.8 percent of the red cell (RBC) transfusions in the US in 1980. Total RBC transfusion rates (total RBCs transfused/1000 hospital admissions) increased between 1980 and 1982 but remained nearly constant between 1982 and 1985. Plasma transfusion dynamics followed a similar pattern, whereas the preoperative deposit of autologous blood by patients accelerated rapidly after 1982. These changes appear to reflect responses to the acquired immune deficiency syndrome epidemic. In contrast, total platelet transfusion rates grew by 76 percent during the 6-year period, approaching total RBC rates by 1985. This is the first reported evidence in such a large sample of transfusions that total RBC transfusion rates have moderated. 相似文献
133.
目的:较大运动强度对腕关节头-月-三角-钩骨四角融合体稳定性究竟有何影响,国内外尚无报道。分析腕关节极限运动与四角融合体稳定性的关系。方法:实验于2005-03/2006-03在南通大学骨科生物力学实验室完成。选用12具未经防腐处理的新鲜尸体肘关节以远标本,切断桡舟月韧带、舟月骨间韧带掌侧部分、舟月骨间韧带背侧部分、桡舟头韧带,建立腕关节不稳定模型后,进行头-月-三角-钩骨四角融合术。融合腕模拟屈、伸、尺偏及桡偏运动,腕关节在安全活动范围内从0°开始,每5°1个等级,每个方向分别施以5万次极限运动。每次运动前后均摄标准前后位及侧位片,测量前后位片融合体高度、融合体宽度、头月正位角及侧位片桡月角、头月角并观察克氏针松动及弯曲情况。所有腕关节均采用运动前后自身对照。结果:①当腕关节屈曲至35°、背伸至25°、桡偏10°、尺偏15°时,极限运动对融合体的稳定性无影响,未出现融合体的解体。②当腕关节屈曲至40°、背伸至30°时,头月角、桡月角及融合体高度与0°相比差异具有显著性意义(P<0.05);当桡偏至15°、尺偏至20°时,融合体的稳定性受到影响,头月正位角、融合体宽度与0°相比差异具有显著性意义(P<0.01)。③克氏针弯曲的临界值:平均在屈曲至43.3°、背伸至32.5°、尺偏至23.3°、桡偏至15.8°时克氏针弯曲。结论:极限运动时,在掌屈40°、背伸30°、桡偏15°、尺偏20°的范围内进行功能锻炼,不会影响四角融合体的稳定性,但应避免环转运动。 相似文献
134.
G Cheng ; DS Chiu ; AS Chung ; HF Wong ; MW Chan ; YK Lui ; FM Choy ; JC Chan ; AH Chan ; ST Lam ; TC Fan 《Transfusion》1996,36(4):347-350
BACKGROUND: A good blood bank must be able to provide compatible blood units promptly to operating room patients with minimal wastage. A "self- service" by nursing staff blood banking system that is safe, efficient, and well-accepted has been developed. STUDY DESIGN AND METHODS: Specific blood units are no longer assigned to surgical patients who have a negative pretransfusion antibody screen, irrespective of the type of surgery. A computer-generated list of the serial numbers of all group-identical blood units currently in the blood bank inventory is provided for each patient. The units themselves are not labeled with a patient's name. The group O list will be provided for group O patients, the group A list for group A patients, and so forth. Should the patient require transfusion during surgery, the operating room nurses go to the refrigerator, remove any group-identical unit, and check the serial number of the unit against the serial numbers on the patient's list. If the serial number is on that list, the blood bank will accept responsibility for compatibility. The system was implemented in 1995. RESULTS: Since implementation, a total of 2154 patients have undergone operations at this hospital. Thirty-two patients received more than 10 units of red cells each. There were no transfusion errors. The crossmatch-to-transfusion ratio was reduced from 1.67 to 1.12. Turnaround time for supplying additional or urgent units to patients in operating room was shortened from 33 to 2.5 minutes. There was no incidence of a blood unit's serial number not being on the list. Work by nurses and technical staff was reduced by nearly 50 percent. CONCLUSION: The "self-service" (by nursing staff) blood banking system described is safe and efficient. It saves staff time and can be easily set up. 相似文献
135.
The effects of alprazolam, quazepam and diazepam on saccadic eye movements, parameters of psychomotor function and the EEG 总被引:1,自引:0,他引:1
MW Blom PR Bartel K. de Sommers CH Van der Meyden PJ Becker 《Fundamental & clinical pharmacology》1990,4(6):653-661
The effects of a single oral dose of alprazolam (1 mg), quazepam (15 mg) and diazepam (10 mg) on the peak saccadic velocity (PSV) of saccadic eye movements (SEM), the Sternberg memory scanning and choice reaction time (SMS-CRT), critical flicker fusion frequency (CFFF), spectral analysis of the EEG and a mood scale were assessed in 9 healthy volunteers in a double-blind, placebo-controlled cross-over study. Alprazolam revealed greater sedative effects than diazepam in the above-mentioned tests. Quazepam had the least sedative effect of the 3 drugs tested, showed a time lag at the onset of its effects and a more prolonged effect on psychomotor impairment than reported previously. 相似文献
136.
Eva Bollen Daniela Puzzo Kris Rutten Lucia Privitera Jochen De Vry Tim Vanmierlo Gunter Kenis Agostino Palmeri Rudi D'Hooge Detlef Balschun Harry MW Steinbusch Arjan Blokland Jos Prickaerts 《Neuropsychopharmacology》2014,39(11):2497-2505
Memory consolidation is defined by the stabilization of a memory trace after acquisition, and consists of numerous molecular cascades that mediate synaptic plasticity. Commonly, a distinction is made between an early and a late consolidation phase, in which early refers to the first hours in which labile synaptic changes occur, whereas late consolidation relates to stable and long-lasting synaptic changes induced by de novo protein synthesis. How these phases are linked at a molecular level is not yet clear. Here we studied the interaction of the cyclic nucleotide-mediated pathways during the different phases of memory consolidation in rodents. In addition, the same pathways were studied in a model of neuronal plasticity, long-term potentiation (LTP). We demonstrated that cGMP/protein kinase G (PKG) signaling mediates early memory consolidation as well as early-phase LTP, whereas cAMP/protein kinase A (PKA) signaling mediates late consolidation and late-phase-like LTP. In addition, we show for the first time that early-phase cGMP/PKG signaling requires late-phase cAMP/PKA-signaling in both LTP and long-term memory formation. 相似文献
137.
138.
139.
Marlieke Visser Mariska Davids Hein J Verberne Wouter EM Kok Hans WM Niessen Lenny MW van Venrooij Riccardo Cocchieri Willem Wisselink Bas AJM de Mol Paul AM van Leeuwen 《Journal of cardiothoracic surgery》2011,6(1):36
Background
Malnutrition is very common in patients undergoing cardiac surgery. Malnutrition can change myocardial substrate utilization which can induce adverse effects on myocardial metabolism and function. We aim to investigate the hypothesis that there is a disturbed amino acids profile in the cardiac surgical patient which can be normalized by (par)enteral nutrition before, during and after surgery, subsequently improving cardiomyocyte structure, cardiac perfusion and glucose metabolism. 相似文献140.
John FR Robertson J Michael Dixon D Mark Sibbering Ali Jahan Ian O Ellis Eddie Channon Pauline Hyman-Taylor Robert I Nicholson Julia MW Gee 《Breast cancer research : BCR》2013,15(2):R18