矽宁对肺泡巨噬细胞功能的影响

矽宁、梯络龙等药物具有明显降低由Ｚｙｍｏｓａｎ刺激的大鼠肺泡巨噬细胞的耗氧量，抑制其释放超氧离子、过氧化氢及化学发光量。矽宁具有较强的亲合肺巨噬细胞的能力，并有剂量－效应关系。     

The comparison of the effects of multi and single doses of buspirone, chlordiazepoxide and hydroxyzine on psychomotor function and EEG

This study compares the effects of buspirone (5 mg), chlordiazepoxide (5 mg), hydroxyzine (10 mg) and placebo on psychomotor function and EEG, when taken thrice daily for a period of two weeks, with those after a single dose administration. Nine healthy volunteers participated in the study. The battery of psychomotor tests included peak velocity of saccadic eye movements (SEM), a Sternberg memory scanning and choice reaction time test (SMS-CRT) and critical flicker fusion frequency (CFFF). The peak velocity of saccadic eye movements was significantly impaired by the single dose of hydroxyzine (P = 0.03) in comparison to the multidose results. A similar comparison regarding buspirone only approached significance (P = 0.07). The SMS-CRT and CFFF did not reveal any difference between the multi and single dose regimens. Spectral analysis of the EEG did not distinguish between the multi and single dosage schedules regarding the respective drugs in the low doses administered.     

Criteria for prioritising access to healthcare resources in New Zealand during an influenza pandemic or at other times of overwhelming demand

During overwhelming demand for resources, such as during an influenza pandemic, clinicians may be required to deny some patients access to a resource (for example ventilation, or hospital admission). However, no pragmatic guidance exists to help clinicians do this. This paper presents criteria for the prioritisation of access to resources during overwhelming demand. The criteria are in the form of eight questions related to the resource and the patients competing for it and are intended to be sufficiently comprehensive and sufficiently succinct to be useful to clinicians who might be required to make such decisions.     

P-31 MR spectroscopy of normal human brain and brain tumors

Image-guided phosphorus-31 magnetic resonance (MR)-localized image-selected in vivo spectroscopy was performed on normal human brain and brain tumors. Peak area ratios, absolute molar concentrations of metabolites, and pH were determined. T1 values in normal brain were measured. The most important finding was that the metabolite concentrations detectable with MR spectroscopy in brain tumors were reduced from 20% to 70%. Phosphomonoesters, phosphodiesters, and phosphocreatine (PCr) showed the greatest decreases, while inorganic phosphate (Pi) showed the least change. The PCr-Pi ratio was significantly reduced in tumors. The pH of brain tumors (7.12 +/- 0.03) was more alkaline than that of normal brain (6.99 +/- 0.01). The authors conclude that the metabolite concentrations and pH in human brain tumors differ significantly from those in normal brain. These differences may be ultimately useful in characterizing tumors in man.