全文获取类型
收费全文 | 108篇 |
免费 | 6篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 7篇 |
妇产科学 | 1篇 |
基础医学 | 16篇 |
临床医学 | 10篇 |
内科学 | 16篇 |
皮肤病学 | 4篇 |
神经病学 | 1篇 |
特种医学 | 5篇 |
外科学 | 37篇 |
综合类 | 1篇 |
预防医学 | 2篇 |
药学 | 3篇 |
肿瘤学 | 10篇 |
出版年
2022年 | 3篇 |
2021年 | 2篇 |
2020年 | 2篇 |
2019年 | 3篇 |
2018年 | 7篇 |
2016年 | 3篇 |
2015年 | 3篇 |
2014年 | 5篇 |
2013年 | 9篇 |
2012年 | 7篇 |
2011年 | 6篇 |
2010年 | 3篇 |
2009年 | 3篇 |
2008年 | 8篇 |
2007年 | 9篇 |
2006年 | 10篇 |
2005年 | 8篇 |
2004年 | 7篇 |
2003年 | 3篇 |
2000年 | 1篇 |
1999年 | 4篇 |
1998年 | 1篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1987年 | 1篇 |
排序方式: 共有114条查询结果,搜索用时 15 毫秒
61.
62.
Seenivasan A Subhagar S Aravindan R Viruthagiri T 《Indian journal of pharmaceutical sciences》2008,70(6):701-709
Lovastatin is a potent hypercholesterolemic drug used for lowering blood cholesterol. Lovastatin acts by competitively inhibiting the enzyme, 3-hydroxy-3-methylglutaryl coenzyme A reductase involved in the biosynthesis of cholesterol. Commercially lovastatin is produced by a variety of filamentous fungi including Penicillium species, Monascus ruber and Aspergillus terreus as a secondary metabolite. Production of lovastatin by fermentation decreases the production cost compared to costs of chemical synthesis. In recent years, lovastatin has also been reported as a potential therapeutic agent for the treatment of various types of tumors and also play a tremendous role in the regulation of the inflammatory and immune response, coagulation process, bone turnover, neovascularization, vascular tone, and arterial pressure. This review deals with the structure, biosynthesis, various modes of fermentation and applications of lovastatin. 相似文献
63.
64.
Paul TV Dinakar J Thomas N Mathews SS Shanthly N Nair A 《Ear, nose, & throat journal》2008,87(2):110-112
Turner syndrome is a hereditary chromosomal anomaly that affects girls and women. A result of gonadal dysgenesis, its primary characteristics are short stature, osteoporosis, neck webbing, and cardiac defects. Turner syndrome may also involve the auditory system and kidneys. We report the case of a woman with Turner syndrome who presented late in adulthood with severe osteoporosis and hypercalcemia. She was subsequently diagnosed with primary hyperparathyroidism secondary to a parathyroid adenoma. After excision of the adenoma, the woman's serum calcium level normalized. To the best of our knowledge, only 4 other cases of Turner syndrome with hyperparathyroidism have been reported in the literature. 相似文献
65.
66.
Paul TV Jacob JJ Vasan SK Thomas N Rajarathnam S Selvan B Paul MJ Abraham D Nair A Seshadri MS 《World journal of surgery》2008,32(4):576-582
The aim of this study was to describe the localization and management of patients with pancreatic insulinomas and determine
the most effective localization and surgical techniques in the presence of significant financial constraints in the patient
population. We retrospectively reviewed the case records of 18 patients with insulinomas treated at our institution over a
period of 10 years. The medical records were reviewed for demographic data, clinical presentation, biochemistry, details of
localization studies, intraoperative findings, postoperative outcome, and long-term follow-up. The sensitivities of the various
localization procedures were calculated using the intraoperative findings as the gold standard. There were 10 men and 8 women
in the study, with a median age of 43 years. All patients underwent a supervised 72-hour fast and developed symptomatic hypoglycemia
within 48 hours. An average of 1.9 localization procedures was performed per patient. Computed tomography (CT) had a sensitivity
of 62% and specificity of 100%. Magnetic resonance imaging and digital subtraction angiography had specificities of 85% and
100%, respectively, with a specificity of 66% and 50%, respectively. Fourteen patients underwent surgery. Intraoperatively
the excised tumor was palpable in nine patients, and all patients had postoperative euglycemia. In five patients the tumor
was not palpable during the time of surgery; three of these patients underwent blind distal pancreactomy, with two patients
having persistent hypoglycemia during the postoperative period. Two patients had a negative exploratory laparotomy. Patients
with a surgical cure were followed up for a mean period of 24 months. On the background of financial constraints in connection
with patient care, CT scanning is a cost-effective option with good specificity. Intraoperative palpation of the tumor and
enucleation is the most effective technique for surgical cure. Blind distal pancreactomy is not advocated for tumors that
are not localized intraoperatively. 相似文献
67.
68.
69.
Aravindan AN Saunders J Cleland B Spicer T Howlin K Wong J Jefferys A Chow J Henderson C Suranyi M 《International urology and nephrology》2007,39(4):1277-1280
Patients with end stage renal disease (ESRD) are predisposed to malignancy. A patient who presented with a persisting fever,
episodically above 38°C, of unknown origin is described. The diagnosis of the illness remained elusive, over repeated hospital
admissions and comprehensive investigations for over 11 weeks, until her last admission when the patient finally represented
with features of acute liver cell failure and succumbed shortly afterwards. A liver biopsy revealed high grade lymphoma, an
uncommon presentation for lymphoma. While malignancy is increased in dialysis patients, lymphoma is a relatively uncommon
malignancy described. This case is a rare incidence of diffuse Non-Hodgkin’s Lymphoma (NHL) isolated to the liver, causing
fever, liver cell failure and death in a hemodialysis patient. 相似文献
70.
Predictors of mortality in elderly patients with acute renal failure in a developing country 总被引:2,自引:0,他引:2
Kohli HS Bhat A Aravindan AN Sud K Jha V Gupta KL Sakhuja V 《International urology and nephrology》2007,39(1):339-344
This prospective study was undertaken to systematically analyze the predictors of mortality in the elderly in a developing
country. All elderly patients with ARF hospitalized at this tertiary care centre over 1 year were studied. Various predictors
analyzed were hospital-acquired ARF, causative factors of ARF, preexisting hypertension and diabetes mellitus, severity of
renal failure (initial and peak serum creatinine, need for dialysis), and complications of ARF: infection during the course
of illness; serum albumin levels and critical illness defined as presence of two or more organ system failures excluding renal
failure. Of 33,301 patients admitted, 4,255 (12.7%) were elderly. Of these 69 (1.6%) had ARF. On analysis of the whole group,
both young and elderly, age >60 years had an independent predictor of mortality (odds ratio 5.6, P = 0.001). Forty-two of the 69 (60.9%) elderly ARF patients died. The mortality was significantly increased in those elderly
with hospital-acquired ARF (79.2%, P = 0.027), those with sepsis as a cause of ARF (71.2%, P = 0.004), those who required dialysis (72.5%, P = 0.022), those developing an infection during the course of ARF (87.9%, P = 0.000) and in those with a critical illness (90.0%, P = 0.00). On logistic regression analysis of those variables that were significant on univariate analysis, only critical illness (odds
ratio 9.97) and infection during course (odds ratio 9.72) were the independent predictors of mortality. To conclude, ARF complicates
only 1.6% of hospitalized elderly patients but is associated with a high mortality rate of 61%. Infection during the course
of illness and critical illness were the independent predictors of mortality. 相似文献