Evaluation of radioiodination of meta-iodobenzylguanidine (MIBG) catalysed by in situ generated Cu(I) and directly added Cu(II)

A reliable method of labelling MIBG with ¹³¹I is reported. Radioiodination involved nucleophilic exchange reaction (160°C, 30 min) catalysed by directly added Cu(II) or by Cu(I) generated in situ by addition of Na₂S₂O₅ to CuSO₄. An additional step of purification of the radiolabelled MIBG by anion exchange chromatography is recommended. The radiochemical (RC) yield was over 90%, while the typical RC purity of ¹³¹I-MIBG was not less than 98%. Higher labelling yield was achieved with Cu(I) than when using Cu(II), and with ¹²⁵I (commercial product) than with ¹³¹I obtained by wet radiochemical processing method in-house. The purity and stability of MIBG-¹³¹I was confirmed by biodistribution studies in monkeys with 0.03% and 0.8% uptake in adrenals and myocardium, respectively. It is concluded that Cu(I) or Cu(II) catalysed radioiodination method is well suited for production of MIBG-¹³¹I.     

CUTANEOUS SCC: METASTASES WITH A PREDILECTION FOR LUNGS 6 YEARS AFTER EXCISION OF THE PRIMARY TUMOUR

SUMMARY An 80-year-old woman developed an ulcerated, moderately differentiated squamous cell carcinoma (SCC) on the lower leg. Despite local excision and radiotherapy, the patient presented 6 years later with multiple lung metastases which were histologically indistinguishable from the original skin tumour. There was no evidence of metastases to lymph nodes or other viscera.     

Zosteriform network of spiradenoma

Spiradenoma is a solitary, deep seated nodule occurring on the ventral surface of the body, especially over the upper half. We are describing a case of spiradenoma with zosteriform arrangement.