全文获取类型
收费全文 | 3279篇 |
免费 | 145篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 26篇 |
儿科学 | 230篇 |
妇产科学 | 199篇 |
基础医学 | 378篇 |
口腔科学 | 55篇 |
临床医学 | 142篇 |
内科学 | 672篇 |
皮肤病学 | 155篇 |
神经病学 | 185篇 |
特种医学 | 142篇 |
外科学 | 631篇 |
综合类 | 73篇 |
预防医学 | 93篇 |
眼科学 | 90篇 |
药学 | 135篇 |
中国医学 | 8篇 |
肿瘤学 | 217篇 |
出版年
2023年 | 23篇 |
2022年 | 39篇 |
2021年 | 83篇 |
2020年 | 53篇 |
2019年 | 55篇 |
2018年 | 87篇 |
2017年 | 76篇 |
2016年 | 83篇 |
2015年 | 78篇 |
2014年 | 144篇 |
2013年 | 164篇 |
2012年 | 248篇 |
2011年 | 262篇 |
2010年 | 156篇 |
2009年 | 120篇 |
2008年 | 177篇 |
2007年 | 163篇 |
2006年 | 157篇 |
2005年 | 103篇 |
2004年 | 121篇 |
2003年 | 91篇 |
2002年 | 84篇 |
2001年 | 77篇 |
2000年 | 59篇 |
1999年 | 60篇 |
1998年 | 37篇 |
1997年 | 29篇 |
1996年 | 31篇 |
1995年 | 22篇 |
1994年 | 14篇 |
1993年 | 14篇 |
1992年 | 35篇 |
1991年 | 40篇 |
1990年 | 48篇 |
1989年 | 35篇 |
1988年 | 47篇 |
1987年 | 34篇 |
1986年 | 29篇 |
1985年 | 26篇 |
1984年 | 14篇 |
1983年 | 21篇 |
1978年 | 12篇 |
1977年 | 15篇 |
1976年 | 15篇 |
1975年 | 16篇 |
1973年 | 15篇 |
1972年 | 15篇 |
1971年 | 13篇 |
1970年 | 15篇 |
1968年 | 12篇 |
排序方式: 共有3431条查询结果,搜索用时 8 毫秒
61.
62.
63.
Romi Barat Anegundha Srinatha Jayantha K. Pandit Neelam Mittal Shampa Anupurba 《Drug delivery》2013,20(8):531-538
Ethylcellulose inserts of niridazole fabricated by casting were studied for in vitro release and in vivo clinical effectiveness. The in vitro drug release was steady and sustained for over 7 days and followed diffusion kinetics. Selected batch, EN3, was evaluated clinically in patients with periodontitis for 6 months. A significant improvement (α ≤ 0.05) in clinical indices from baseline was observed. Intergroup study revealed a significant (α ≤ 0.01) change in the bleeding index, gingival index, plaque index, calculus criteria, and pocket depth. Significant reduction in total bacterial count in gingival crevicular fluid was observed before and postdevice insertion, as well as between control and treatment groups. 相似文献
64.
Atul Deodhar Manish Mittal Patrick Reilly Yanjun Bao Shivaji Manthena Jaclyn Anderson Avani Joshi 《Clinical rheumatology》2016,35(7):1769-1776
This study aimed to identify providers involved in diagnosing ankylosing spondylitis (AS) following back pain diagnosis in the USA and to identify factors leading to the delay in rheumatology referrals. The Truven Health MarketScan® US Commercial Database was searched for patients aged 18–64 years with back pain diagnosis in a non-rheumatology setting followed by AS diagnosis in any setting during January 2000–December 2012. Patients with a rheumatologist visit on or before AS diagnosis were considered referred. Cox regression was used to determine factors associated with referral time after adjusting for age, sex, comorbidities, physician specialty, drug therapy, and imaging procedures. Of 3336 patients included, 1244 (37 %) were referred to and diagnosed by rheumatologists; the others were diagnosed in primary care (25.7 %), chiropractic/physical therapy (7 %), orthopedic surgery (3.8 %), pain clinic (3.6 %), acute care (3.4 %), and other (19.2 %) settings. Median time from back pain diagnosis to rheumatology referral was 307 days and from first rheumatologist visit to AS diagnosis was 28 days. Referred patients were more likely to be younger (hazard ratio [HR]?=?0.986; p?<?0.0001), male (HR?=?1.15; p?=?0.0163), diagnosed with uveitis (HR?=?1.49; p?=?0.0050), referred by primary care physicians (HR?=?1.96; p?<?0.0001), prescribed non-steroidal anti-inflammatory drugs (HR?=?1.55; p?<?0.0001), disease-modifying antirheumatic drugs (HR?=?1.33; p?<?0.0001), and tumor necrosis factor inhibitors (HR?=?1.40; p?=?0.0036), and to have had spinal/pelvic X-ray prior to referral (HR?=?1.28; p?=?0.0003). During 2000–2012, most patients with AS were diagnosed outside of rheumatology practices. The delay before referral to rheumatology was 10 months; AS diagnosis generally followed within a month. Earlier referral of patients with AS signs and symptoms may lead to more timely diagnosis and appropriate treatment. 相似文献
65.
66.
67.
68.
Deepa John Swetha Sara Philip Rashmi Mittal Sheeja Susan John Padma Paul 《Indian journal of ophthalmology》2015,63(11):843-846
Purpose:
Ocular trauma is a major cause of acquired monocular blindness in children. Firework injuries account for 20% of ocular trauma. The purpose of our study was to document the profile of ocular firework injuries in children during the festive season of Diwali and to determine the prevalence of unilateral blindness in them.Materials and Methods:
A retrospective chart analysis of ocular firework injury in children during the festival of Diwali from 2009 to 2013, conducted in a tertiary care eye center in Tamil Nadu, Southern India. Children below 18 years of age with ocular firework injuries who presented to the emergency department for 3 consecutive days - the day of Diwali, 1 day before, and 1 day after Diwali - were included in this study.Results:
Eighty-four children presented with firework-related ocular injuries during the study period. Male to female ratio was 4:1 with mean age 9.48 ± 4 years. Forty-four percentage required hospitalization. The prevalence of unilateral blindness in children due to fireworks was found to be 8% (95% confidence interval - 2–13%).Conclusion:
Vision 2020 gives high priority to avoidable blindness, especially in children. In our study, for every 12 children who presented with firecracker injury, one resulted in unilateral blindness. This is an avoidable cause of blindness. Awareness needs to be created, and changes in policy regarding sales and handling of firecrackers including mandatory use of protective eyewear should be considered. 相似文献69.
Louis Gendron Nitish Mittal Hélène Beaudry Wendy Walwyn 《British journal of pharmacology》2015,172(2):403-419
Within the opioid family of receptors, δ (DOPrs) and μ opioid receptors (MOPrs) are typical GPCRs that activate canonical second-messenger signalling cascades to influence diverse cellular functions in neuronal and non-neuronal cell types. These receptors activate well-known pathways to influence ion channel function and pathways such as the map kinase cascade, AC and PI3K. In addition new information regarding opioid receptor-interacting proteins, downstream signalling pathways and resultant functional effects has recently come to light. In this review, we will examine these novel findings focusing on the DOPr and, in doing so, will contrast and compare DOPrs with MOPrs in terms of differences and similarities in function, signalling pathways, distribution and interactions. We will also discuss and clarify issues that have recently surfaced regarding the expression and function of DOPrs in different cell types and analgesia.
LINKED ARTICLES
This article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-2 相似文献70.