全文获取类型
收费全文 | 41056篇 |
免费 | 2712篇 |
国内免费 | 131篇 |
专业分类
耳鼻咽喉 | 372篇 |
儿科学 | 1001篇 |
妇产科学 | 957篇 |
基础医学 | 5280篇 |
口腔科学 | 753篇 |
临床医学 | 3897篇 |
内科学 | 7923篇 |
皮肤病学 | 594篇 |
神经病学 | 4402篇 |
特种医学 | 1325篇 |
外科学 | 6830篇 |
综合类 | 470篇 |
现状与发展 | 1篇 |
一般理论 | 36篇 |
预防医学 | 3331篇 |
眼科学 | 1024篇 |
药学 | 2703篇 |
中国医学 | 114篇 |
肿瘤学 | 2886篇 |
出版年
2023年 | 231篇 |
2022年 | 420篇 |
2021年 | 909篇 |
2020年 | 559篇 |
2019年 | 834篇 |
2018年 | 1061篇 |
2017年 | 752篇 |
2016年 | 754篇 |
2015年 | 895篇 |
2014年 | 1356篇 |
2013年 | 1775篇 |
2012年 | 2887篇 |
2011年 | 3003篇 |
2010年 | 1699篇 |
2009年 | 1538篇 |
2008年 | 2735篇 |
2007年 | 2906篇 |
2006年 | 2736篇 |
2005年 | 2674篇 |
2004年 | 2571篇 |
2003年 | 2403篇 |
2002年 | 2215篇 |
2001年 | 424篇 |
2000年 | 377篇 |
1999年 | 419篇 |
1998年 | 460篇 |
1997年 | 394篇 |
1996年 | 391篇 |
1995年 | 324篇 |
1994年 | 312篇 |
1993年 | 267篇 |
1992年 | 280篇 |
1991年 | 229篇 |
1990年 | 185篇 |
1989年 | 165篇 |
1988年 | 186篇 |
1987年 | 170篇 |
1986年 | 155篇 |
1985年 | 160篇 |
1984年 | 160篇 |
1983年 | 168篇 |
1982年 | 205篇 |
1981年 | 179篇 |
1980年 | 152篇 |
1979年 | 99篇 |
1978年 | 124篇 |
1977年 | 122篇 |
1976年 | 92篇 |
1975年 | 99篇 |
1974年 | 87篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
K Michael Cummings Anthony Brown Richard O'Connor 《Cancer epidemiology, biomarkers & prevention》2007,16(6):1070-1076
This study examines the history of the cigarette controversy using the tobacco documents as a roadmap to explore the following four questions: (a) What did tobacco companies know about the health risks of smoking and when did they know it? (b) What evidence is there that tobacco companies conspired to deliberately mislead the public about the health risks of smoking? (c) How were scientists involved in the cigarette controversy? (d) Have tobacco companies changed the way they do business since signing the 1998 Master Settlement Agreement? The tobacco companies knew and for most part accepted the evidence that cigarette smoking was a cause of cancer by the late 1950s. The documents also reveal that the tobacco companies helped manufacture the smoking controversy by funding scientific research that was intended to obfuscate and prolong the debate about smoking and health. Today, the tobacco companies acknowledge that smoking is a cause of disease, but they have not materially altered the way they do business. In our opinion, it is not sufficient for the tobacco industry to merely concede the obvious point that smoking is a cause of disease when it is evident that decades of misinformation has resulted in a public that is massively ignorant about the risks of smoking low-tar cigarettes, nicotine addiction, and secondhand smoke exposure. Public education efforts are still needed to correct these misperceptions along with government oversight to ensure that the industry is not permitted to mislead the public further. If the past 50 years have taught us anything, it is that the tobacco industry cannot be trusted to put the public's interest above their profits no matter what they say. 相似文献
92.
Anthony H Harris Richard H Osborne Catherine L Streeton Helen McNeil 《Supportive care in cancer》2002,10(6):486-493
The goal of this work was to investigate preference techniques to value potential health gains from treatments of Kaposi sarcoma (KS). The study was designed to take the form of face-to-face interviews with a sample of men with a history of HIV/AIDS ( n=15) or HIV/AIDS and KS ( n=17). The main outcome measure was quality of life (QoL) associated with various KS disease states expressed on a scale from 0 (death) to 1 (perfect health), obtained though time trade-off (TTO) and rating scale techniques. For cutaneous lesions only, the mean TTO preference score value was 0.27. In other words, the men were willing to trade a life expectancy of 5 years for a shorter period (1.4 years) in perfect health. More severe KS health states were rated lower (0.07-0.09). The mean rating scale value for cutaneous lesions only was 0.11 and ranged from -0.10 to -0.04 for the more severe conditions; these values were systematically lower than the TTO ( P=0.014). A large overall potential gain in QoL from treatment (partial response minus stable disease) was found for each condition to be reflected in both the TTO (from 0.31 to 0.55) and the rating scale (from 0.38 to 0.44). Respondents associate KS health states with extremely poor QoL and indicate that large gains are possible through modest treatment effects. While TTO returns higher values than the rating scale, potential gains from treatments were similar. The techniques appear to be suitable for application to QoL and economic evaluation of treatments of KS. 相似文献
93.
94.
N. Torlone A. Piazza M. Valeri P. I. Monaco L. Provenzani E. Poggi D. Adorno C. U. Casciani 《Transplant international》1992,5(Z1):S676-S678
Donor-specific anti-HLA antibodies were studied by cytotoxicity crossmatching (CTXM) and flow cytometry crossmatching (FCXM) in 117 kidney transplant candidates; the same study was carried out in 33 cadaver-donor kidney recipients, during the first 3 post-transplant months, for which donor cells were available. Pre-transport evaluation showed that 82.9 % of subjects were CTXM negative/FCXM negative, 6.8 % of patients were positive in both tests, and 10.3 % were CTXM negative/FCCM positive. Post-transplant monitoring for donor-specific antibodies (Abs-DS) showed that nine recipients (27.3 %) were FCXM positive; six of them were IgG + and three IgM +. In comparing these results with the clinical course, a significant association between FCXM IgG + and rejection episodes was observed (P < 0.01). 相似文献
95.
Anthony L. Neely 《Journal of clinical periodontology》1992,19(6):367-372
A cross-sectional radiographic screening was performed on bite-wing pairs (BW) from 1872 10-12 year old schoolchildren in the Greater Worcester, Massachusetts area to assess the prevalence of juvenile periodontitis (JP). The 3-stage screening process entailed: (1) visual identification of possible cases based upon a visual assessment of BW for interproximal crestal bone levels greater than or equal to 2 mm from the cemento-enamel junction (CEJ) on greater than or equal to 1 permanent first molar; (2) identification of probable cases based upon BW from possible cases measured with a transparent ruler calibrated in millimeters; (3) finally, clinical confirmation of JP in consenting probable cases. A total of 1038 subjects were eligible to be included in the study (greater than or equal to 3 mesial sites readable). Of the 1038 eligible subjects, 117 possible and 103 probable cases were identified in stage 1 and stage 2, respectively. A total of 99 probable cases could be contacted and 43 were examined clinically. Two cases of JP were confirmed clinically in stage 3, yielding a prevalence rate of 4.6/1000. Specifically, this report defines a rate of JP in 10-12 year-old schoolchildren for the first time. In addition, these results indicate that BW can be used to identify children with JP from large data sets. However, further studies including complete clinical and radiographic examinations are necessary to determine whether this method is adequate for large epidemiologic studies. 相似文献
96.
97.
A. Ferretti E. Monaco L. Labianca F. D’Angelo A. De Carli F. Conteduca 《Journal of orthopaedics and traumatology》2006,7(3):136-141
Healing of a tendon graft to a bone tunnel is slower than the healing of a bone plug. Therefore, the device chosen for hamstring
fixation may need to maintain its strength and stiffness longer than the device chosen for bone-tendon-bone fixation. We evaluated,
in an extraarticular ovine model, how 4 and 12 weeks of implantation affect the strength of a tendon graft fixed to bone with
the Evolgate. The long digital extensor tendon was transplanted and fixed with the Evolgate into a 30-mm long, 8 mm diameter
bone tunnel drilled in the tibial metaphysis of both posterior limbs of 15 skeletally mature Suffolk sheep. Immediately after
implantation, and 4 and 12 weeks later, biomechanical cyclic load tests in 50 N increments were performed until failure to
evaluate the ultimate failure load (UFL). Histological analysis was also performed at 4 and 12 weeks. Biomechanical tests
revealed a UFL of 339±120 N at time 0, and increases to 635±19 N (4 weeks) and to 867±80 N (12 weeks). The differences between
all 3 groups were significant (p<0.001, paired t test). The histological evaluation showed a layer of cellular, fibrous tissue between the tendon and the bone, along the
length of the bone tunnel; this layer progressively matured and reorganized during the healing process. The collagen fibers
that attached the tendon to the bone resembled Sharpey’s fibers. The strength of the interface significantly and progressively
increased between weeks 4 and 12 after transplantation, and was associated with a degree of bone ingrowth noted histologically.
The use of the Evolgate seems not to interfere with the bone ingrowth after implantation, allowing an improvement in strength
of the bonetendon- device complex. 相似文献
98.
A. Gautam S.A. Fischer A.F. Yango R.Y. Gohh P.E. Morrissey A.P. Monaco 《International immunopharmacology》2006,6(13-14):2023
Cell mediated immunity (CMI) was assessed by the ImmuKnow assay in 12 patients after kidney transplantation, who presented with viral infection. Treatment included lowering of immunosuppression in all cases and antiviral treatment if indicated. The assay was repeated during the follow up. The ImmuKnow assay at time of presentation of viral infections was 56.8 ± 58.2 (range 3–178; median 22) ATP ng/ml. With the clearance of viral infection and lowering of immunosuppression, the assay showed an increase in the level of CMI at 194.5 ± 118.9 (range 53–409; median 150) ATP ng/ml. There was viral clearance or stabilization in all cases and there was no incidence of allograft rejection. The ImmuKnow assay of CMI can be used to titrate initial immunosuppression reduction and its subsequent increase, in patients with viral infection after transplantation. 相似文献
99.
Anthony N DeMaria 《Journal of the American College of Cardiology》2006,47(8):1722-1723
100.