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621.
Larsen Marit Goemans Anouk Baste Valborg Wilderjans Tom F. Lehmann Stine 《Quality of life research》2021,30(2):543-554
Quality of Life Research - Few studies have investigated possible predictors of positive outcomes for youths in foster care. The aim of this prospective follow-up study was to examine quality of... 相似文献
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Niels Van Regenmortel Steven Hendrickx Ella Roelant Ingrid Baar Karolien Dams Karen Van Vlimmeren Bart Embrecht Anouk Wittock Jeroen M. Hendriks Patrick Lauwers Paul E. Van Schil Amaryllis H. Van Craenenbroeck Walter Verbrugghe Manu L. N. G. Malbrain Tim Van den Wyngaert Philippe G. Jorens 《Intensive care medicine》2019,45(10):1422-1432
To determine the effects of the sodium content of maintenance fluid therapy on cumulative fluid balance and electrolyte disorders. We performed a randomized controlled trial of adults undergoing major thoracic surgery, randomly assigned (1:1) to receive maintenance fluids containing 154 mmol/L (Na154) or 54 mmol/L (Na54) of sodium from the start of surgery until their discharge from the ICU, the occurrence of a serious adverse event or the third postoperative day at the latest. Investigators, caregivers and patients were blinded to the treatment. Primary outcome was cumulative fluid balance. Electrolyte disturbances were assessed as secondary endpoints, different adverse events and physiological markers as safety and exploratory endpoints. We randomly assigned 70 patients; primary outcome data were available for 33 and 34 patients in the Na54 and Na154 treatment arms, respectively. Estimated cumulative fluid balance at 72 h was 1369 mL (95% CI 601–2137) more positive in the Na154 arm (p < 0.001), despite comparable non-study fluid sources. Hyponatremia < 135 mmol/L was encountered in four patients (11.8%) under Na54 compared to none under Na154 (p = 0.04), but there was no significantly more hyponatremia < 130 mmol/L (1 versus 0; p = 0.31). There was more hyperchloremia > 109 mmol/L under Na154 (24/35 patients, 68.6%) than under Na54 (4/34 patients, 11.8%) (p < 0.001). The treating clinicians discontinued the study due to clinical or radiographic fluid overload in six patients receiving Na154 compared to one patient under Na54 (excess risk 14.2%; 95% CI − 0.2–30.4%, p = 0.05). In adult surgical patients, sodium-rich maintenance solutions were associated with a more positive cumulative fluid balance and hyperchloremia; hypotonic fluids were associated with mild and asymptomatic hyponatremia. 相似文献
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Jack Dummer Claudia C. Dobler Mark Holmes Daniel Chambers Ian A. Yang Lianne Parkin Sheree Smith Peter Wark Anouk Dev Sandra Hodge Eli Dabscheck Julian Gooi Sameh Samuel Steven Knowles Anne E. Holland 《Respirology (Carlton, Vic.)》2020,25(3):321-335
AATD is a common inherited disorder associated with an increased risk of developing pulmonary emphysema and liver disease. Many people with AATD‐associated pulmonary emphysema remain undiagnosed and therefore without access to care and counselling specific to the disease. AAT augmentation therapy is available and consists of i.v. infusions of exogenous AAT protein harvested from pooled blood products. Its clinical efficacy has been the subject of some debate and the use of AAT augmentation therapy was recently permitted by regulators in Australia and New Zealand, although treatment is not presently subsidized by the government in either country. The purpose of this position statement is to review the evidence for diagnosis and treatment of AATD‐related lung disease with reference to the Australian and New Zealand population. The clinical efficacy and adverse events of AAT augmentation therapy were evaluated by a systematic review, and the GRADE process was employed to move from evidence to recommendation. Other sections address the wide range of issues to be considered in the care of the individual with AATD‐related lung disease: when and how to test for AATD, changing diagnostic techniques, monitoring of progression, disease in heterozygous AATD and pharmacological and non‐pharmacological therapy including surgical options for severe disease. Consideration is also given to broader issues in AATD that respiratory healthcare staff may encounter: genetic counselling, patient support groups, monitoring for liver disease and the need to establish national registries for people with AATD in Australia and New Zealand. 相似文献
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A high sugar intake is a subject of scientific debate due to the suggested health implications and recent free sugar recommendations by the WHO. The objective was to complete a food composition table for added and free sugars, to estimate the intake of total sugars, free sugars, and added sugars, adherence to sugar guidelines and overall diet quality in Dutch children and adults. In all, 3817 men and women (7–69 years) from the Dutch National Food Consumption Survey 2007–2010 were studied. Added and free sugar content of products was assigned by food composition tables and using labelling and product information. Diet was assessed with two 24-h recalls. Diet quality was studied in adults with the Dutch Healthy Diet-index. Total sugar intake was 22% Total Energy (%TE), free sugars intake 14 %TE, and added sugar intake 12 %TE. Sugar consumption was higher in children than adults. Main food sources of sugars were sweets and candy, non-alcoholic beverages, dairy, and cake and cookies. Prevalence free sugar intake <10 %TE was 5% in boys and girls (7–18 years), 29% in women, and 33% in men. Overall diet quality was similar comparing adults adherent and non-adherent to the sugar guidelines, although adherent adults had a higher intake of dietary fiber and vegetables. Adherence to the WHO free sugar guidelines of <5 %TE and <10 %TE was generally low in the Netherlands, particularly in children. Adherence to the added and free sugar guidelines was not strongly associated with higher diet quality in adults. 相似文献
629.
Sandra P. Crispim Anouk Geelen Jeanne H. M. de Vries Heinz Freisling Olga W. Souverein Paul J. M. Hulshof Marga C. Ocke Hendriek Boshuizen Lene F. Andersen Jiri Ruprich Willem De Keizer Inge Huybrechts Lionel Lafay Maria S. de Magistris Fulvio Ricceri Rosario Tumino Vittorio Krogh H. Bas Bueno-de-Mesquita Joline W. J. Beulens Marie-Christine Boutron-Ruault Androniki Naska Francesca L. Crowe Heiner Boeing Alison McTaggart Rudolf Kaaks Pieter van’t Veer Nadia Slimani 《European journal of nutrition》2012,51(8):997-1010
Purpose
We investigated whether group-level bias of a 24-h recall estimate of protein and potassium intake, as compared to biomarkers, varied across European centers and whether this was influenced by characteristics of individuals or centers.Methods
The combined data from EFCOVAL and EPIC studies included 14 centers from 9 countries (n?=?1,841). Dietary data were collected using a computerized 24-h recall (EPIC-Soft). Nitrogen and potassium in 24-h urine collections were used as reference method. Multilevel linear regression analysis was performed, including individual-level (e.g., BMI) and center-level (e.g., food pattern index) variables.Results
For protein intake, no between-center variation in bias was observed in men while it was 5.7% in women. For potassium intake, the between-center variation in bias was 8.9% in men and null in women. BMI was an important factor influencing the biases across centers (p?<?0.01 in all analyses). In addition, mode of administration (p?=?0.06 in women) and day of the week (p?=?0.03 in men and p?=?0.06 in women) may have influenced the bias in protein intake across centers. After inclusion of these individual variables, between-center variation in bias in protein intake disappeared for women, whereas for potassium, it increased slightly in men (to 9.5%). Center-level variables did not influence the results.Conclusion
The results suggest that group-level bias in protein and potassium (for women) collected with 24-h recalls does not vary across centers and to a certain extent varies for potassium in men. BMI and study design aspects, rather than center-level characteristics, affected the biases across centers. 相似文献630.
Alasdair G. Rooney Anouk Netten Shanne McNamara Sara Erridge Sharon Peoples Ian Whittle Belinda Hacking Robin Grant 《Supportive care in cancer》2014,22(4):1059-1069