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排序方式: 共有107条查询结果,搜索用时 15 毫秒
81.
Arnone Annachiara Allocca Michela Di Dato Rossella Puccini Giulia Laghai Iashar Rubino Federica Nerattini Matilde Ramat Silvia Lombardi Gemma Ferrari Camilla Bessi Valentina Sorbi Sandro De Cristofaro Maria Teresa Polito Cristina Berti Valentina 《Neurological sciences》2022,43(9):5333-5341
Neurological Sciences - The early differential diagnosis among neurodegenerative parkinsonian disorders becomes essential to set up the correct clinical-therapeutic approach. The increased... 相似文献
82.
Tinazzi Michele Fiorio Mirta Berardelli Alfredo Bonetti Bruno Bonifati Domenico Marco Burlina Alessandro Cagnin Annachiara Calabria Francesca Corbetta Maurizio Cortelli Pietro Giometto Bruno Guidoni Silvia Vittoria Lopiano Leonardo Mancardi Gianluigi Marchioretto Fabio Pellegrini Maria Teatini Francesco Tedeschi Gioacchino Tesolin Lucia Turinese Emanuele Zappia Mario Marotta Angela 《Journal of neurology》2022,269(5):2549-2559
Journal of Neurology - Functional neurological disorders (FND) are disabling medical conditions commonly seen in neurological practice. Neurologists play an essential role in managing FND, from... 相似文献
83.
84.
Annachiara Aldrovandi Erica Maffei Alessandro Palumbo Sara Seitun Chiara Martini Valerio Brambilla Alessandra Zuccarelli Giuseppe Tarantini Annick C. Weustink Nico R. Mollet Livia Ruffini Girolamo Crisi Diego Ardissino Pim J. de Feyter Gabriel P. Krestin Filippo Cademartiri 《European radiology》2009,19(7):1653-1660
The aim of this study was to determine the predictive value of 64-slice computed tomography coronary angiography (CTCA) for
major cardiac events in patients with suspected coronary artery disease (CAD). A total of 187 consecutive patients (119 men,
age 62.5 ± 10.5 years) without known heart disease underwent single-source 64-slice CTCA (Somatom Sensation 64, Siemens) for
clinical suspicion of CAD. Patients underwent follow-up for the occurrence of cardiac death, nonfatal myocardial infarction,
unstable angina and cardiac revascularization. In total, 2,822 coronary segments were assessed. Forty-two segments (1.5%)
were not assessable because of insufficient image quality. Overall, CTCA revealed absence of CAD in 65 (34.7%) patients, nonobstructive
CAD (coronary plaque ≤50%) in 87 (46.5%) patients and obstructive CAD (>50%) in 35 (18.8%) patients. A total of 20 major cardiac
events (3 myocardial infarctions, 16 cardiac revascularizations, 1 unstable angina) occurred during a mean follow-up of 24 months.
One noncardiac death occurred. Seventeen events occurred in the group of patients with obstructive CAD and three events occurred
in the group of nonobstructive CAD. The event rate was 0% among patients with normal coronary arteries at CTCA. CTCA has a
100% negative predictive value for major cardiac events at 24-month follow-up in patients with normal coronary arteries. 相似文献
85.
Cademartiri F La Grutta L Malagò R Alberghina F Meijboom WB Pugliese F Maffei E Palumbo AA Aldrovandi A Fusaro M Brambilla V Coruzzi P Midiri M Mollet NR Krestin GP 《European radiology》2008,18(4):781-791
The aim of our study was to assess the prevalence of variants and anomalies of the coronary artery tree in patients who underwent 64-slice computed tomography coronary angiography (CT-CA) for suspected or known coronary artery disease. A total of 543 patients (389 male, mean age 60.5 +/- 10.9) were reviewed for coronary artery variants and anomalies including post-processing tools. The majority of segments were identified according to the American Heart Association scheme. The coronary dominance pattern results were: right, 86.6%; left, 9.2%; balanced, 4.2%. The left main coronary artery had a mean length of 112 +/- 55 mm. The intermediate branch was present in the 21.9%. A variable number of diagonals (one, 25%; two, 49.7%; more than two, 24%; none, 1.3%) and marginals (one, 35.2%; two, 46.2%; more than two, 18%; none, 0.6%) was visualized. Furthermore, CT-CA may visualize smaller branches such as the conus branch artery (98%), the sinus node artery (91.6%), and the septal branches (93%). Single or associated coronary anomalies occurred in 18.4% of the patients, with the following distribution: 43 anomalies of origin and course, 68 intrinsic anomalies (59 myocardial bridging, nine aneurisms), three fistulas. In conclusion, 64-slice CT-CA provides optimal visualization of the variable and complex anatomy of coronary arteries because of the improved isotropic spatial resolution and flexible post-processing tool. 相似文献
86.
87.
Rachel A. Rigg Laura D. Healy Tiffany T. Chu Anh T. P. Ngo Annachiara Mitrugno Jevgenia Zilberman-Rudenko 《Platelets》2019,30(1):126-135
Human platelets express two protease-activated receptors (PARs), PAR1 (F2R) and PAR4 (F2RL3), which are activated by a number of serine proteases that are generated during pathological events and cause platelet activation. Recent interest has focused on PAR4 as a therapeutic target, given PAR4 seems to promote experimental thrombosis and procoagulant microparticle formation, without a broadly apparent role in hemostasis. However, it is not yet known whether PAR4 activity plays a role in platelet-leukocyte interactions, which are thought to contribute to both thrombosis and acute or chronic thrombo-inflammatory processes. We sought to determine whether PAR4 activity contributes to granule secretion from activated platelets and platelet-leukocyte interactions. We performed in vitro and ex vivo studies of platelet granule release and platelet-leukocyte interactions in the presence of PAR4 agonists including PAR4 activating peptide, thrombin, cathepsin G, and plasmin in combination with small-molecule PAR4 antagonists. Activation of human platelets with thrombin, cathepsin G, or plasmin potentiated platelet dense granule secretion that was specifically impaired by PAR4 inhibitors. Platelet-leukocyte interactions and platelet P-selectin exposure the following stimulation with PAR4 agonists were also impaired by activated PAR4 inhibition in either a purified system or in whole blood. These results indicate PAR4-specific promotion of platelet granule release and platelet-leukocyte aggregate formation and suggest that pharmacological control of PAR4 activity could potentially attenuate platelet granule release or platelet-leukocyte interaction-mediated pathological processes. 相似文献
88.
Deren ?zcan Murat Derbent Deniz Se?kin Yunus Emre Bikmaz Muhte?em A?ildere Annachiara De Sandre-Giovannoli Nicolas Lévy Berkan Gürakan 《ANNALS OF DERMATOLOGY》2013,25(4):483-488
Neu-Laxova syndrome is a rare, lethal, autosomal recessive disorder characterized by intrauterine growth retardation, central nervous system anomalies, skin findings, such as ichthyosis, edema, collodion baby and harlequin fetus, facial dysmorphic features, limb anomalies and genital hypoplasia. Although it is generally a lethal condition, cases of such patients who lived beyond 6 months and 10 months of age have been reported. Here, we describe an 8-year-old boy who was born with collodion membrane, facial dysmorphic features, limb anomalies, genital hypoplasia and pachygyria. He had no major health problems over the course of 8 years of follow-up, except for mild mental/motor retardation, ichthyosis, facial dysmorphic features and limb anomalies. Based on these features, we suggest that because Neu-Laxova syndrome represents a heterogeneous phenotype, our case may be a milder variant of this syndrome or a new genetic entity. 相似文献
89.
Gaetano Alfano Niccol Morisi Monica Frisina Annachiara Ferrari Francesco Fontana Roberto Tonelli Erica Franceschini Marianna Meschiari Gabriele Donati Giovanni Guaraldi 《Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive》2022,30(1):11
90.
Stavros Spiliopoulos Maria Teresa Zurlo Annachiara Casella Letizia Laera Giammarco Surico Alessia Surgo Alba Fiorentino Nicola de Angelis Roberto Calbi Riccardo Memeo Riccardo Inchingolo 《World journal of gastrointestinal oncology》2021,13(12):2064-2075
Pancreatic cancer is the 7th leading cause of death due to cancer in industrialized countries and the 11th most common cancer globally, with 458918 new cases (2.5% of all cancers) and 432242 deaths (4.5% of all cancer deaths) in 2018. Unfortunately, 80% to 90% of the patients present with unresectable disease, and the reported 5-year survival rate range between 10% and 25%, even after successful resection with tumor-free margins. Systemic chemotherapy, radiotherapy, and minimally invasive image-guided procedures that have emerged over the past years, are used for the management of non-operable PC. This review focuses on currently available non-surgical options of locally advanced pancreatic cancer. 相似文献