全文获取类型
收费全文 | 2862篇 |
免费 | 297篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 65篇 |
妇产科学 | 40篇 |
基础医学 | 417篇 |
口腔科学 | 57篇 |
临床医学 | 478篇 |
内科学 | 610篇 |
皮肤病学 | 22篇 |
神经病学 | 198篇 |
特种医学 | 209篇 |
外科学 | 344篇 |
综合类 | 92篇 |
一般理论 | 1篇 |
预防医学 | 220篇 |
眼科学 | 36篇 |
药学 | 253篇 |
肿瘤学 | 133篇 |
出版年
2023年 | 21篇 |
2022年 | 33篇 |
2021年 | 69篇 |
2020年 | 29篇 |
2019年 | 44篇 |
2018年 | 58篇 |
2017年 | 49篇 |
2016年 | 53篇 |
2015年 | 54篇 |
2014年 | 76篇 |
2013年 | 107篇 |
2012年 | 138篇 |
2011年 | 147篇 |
2010年 | 83篇 |
2009年 | 112篇 |
2008年 | 139篇 |
2007年 | 153篇 |
2006年 | 127篇 |
2005年 | 160篇 |
2004年 | 132篇 |
2003年 | 152篇 |
2002年 | 143篇 |
2001年 | 65篇 |
2000年 | 69篇 |
1999年 | 50篇 |
1998年 | 67篇 |
1997年 | 65篇 |
1996年 | 60篇 |
1995年 | 45篇 |
1994年 | 51篇 |
1993年 | 45篇 |
1992年 | 32篇 |
1991年 | 40篇 |
1990年 | 34篇 |
1989年 | 53篇 |
1988年 | 47篇 |
1987年 | 37篇 |
1986年 | 23篇 |
1985年 | 30篇 |
1984年 | 25篇 |
1983年 | 20篇 |
1982年 | 31篇 |
1981年 | 22篇 |
1980年 | 26篇 |
1979年 | 12篇 |
1978年 | 26篇 |
1977年 | 19篇 |
1976年 | 12篇 |
1972年 | 12篇 |
1967年 | 12篇 |
排序方式: 共有3187条查询结果,搜索用时 0 毫秒
31.
Guillaume Fournié Wendy Beauvais Bryony A. Jones Juan Lubroth Francesca Ambrosini Félix Njeumi Angus Cameron Dirk U. Pfeiffer 《Emerging infectious diseases》2013,19(1):151-153
After the 2011 declaration of rinderpest disease eradication, we surveyed 150 countries about rinderpest virus stocks. Forty-four laboratories in 35 countries held laboratory-attenuated strains, field strains, or diagnostic samples. Vaccine and reagent production and laboratory experiments continued. Rigorous standards are necessary to ensure that stocks are kept under safe conditions. 相似文献
32.
33.
Quality control of multidrug resistance assays in adult acute leukemia: correlation between assays for P-glycoprotein expression and activity 总被引:1,自引:5,他引:1
Broxterman HJ; Sonneveld P; Feller N; Ossenkoppele GJ; Wahrer DC; Eekman CA; Schoester M; Lankelma J; Pinedo HM; Lowenberg B; Schuurhuis GJ 《Blood》1996,87(11):4809-4816
We have compared multiple assays for the P-glycoprotein (Pgp/MDR1) phenotype in fresh and thawed adult acute leukemia to validate and quantitate measures for the expression and function of Pgp. The results are related to the Pgp-expressing KB8 and KB8-5 call lines. The most sensitive assay was the measurement of modulation of the rhodamine 123 (R123) fluorescence by 2 micromol/L PSC833, followed by the modulation of the probe calcein-AM. We also found a good intralaboratory and interlaboratory correlation between the values of the R123/PSC833 assay for fresh as well as thawed samples. In addition, the affects of PSC833 on 3H-daunorubicin (DNR) accumulation, DNR fluorescence, and 3H- vincristine accumulation were very similar. The correlation between the DNR/PSC833 and R123/PSC833 test was r = .86 (N = 51). The modulation of drug accumulation by 8 micromol/L verapamil was the some as the PSC833 effect for DNR (117%, N = 21), but was higher for vincristine in every single case (161% v 121%, N = 22; P< .001), indicating additional verapamil effects, not related to Pgp. The correlation of the staining of viable cells for Pgp with the monoclonal antibody MRK16 was r = .77 (N = 52) for the R123/PSC833 functional test and r = .84 (N = 50) for the DNR/PSC833 test. From these results it could be calculated that a maximal increase of the mean DNR accumulation of about 50% can be achieved by blocking Pgp pump activity with PSC833 in leukemic blast samples with the highest mean Pgp expression. Subpopulations of blast calls with higher Pgp activity are likely to be present. Their relevance has to be studied further. The methods outlined here allow the reliable, quantitative monitoring of the Pgp/MDR1 phenotype in leukemias in multicentered, clinical Pgp modulation studies. 相似文献
34.
Hysterosalpingography was performed in 31 patients by means of a low-dose scanning-beam digital radiographic system. The technique permits adequate evaluation of gynecologic abnormalities while allowing significant reduction in radiation: 2.4-mR (6.1 X 10(-7) C/kg) exposure to the skin and 0.7-mrad (7 X 10(-6) Gy) mean dose to the ovaries per image obtained. Sixteen patients demonstrated readily recognizable and documented abnormalities, corroborated by laparoscopy, laparotomy, or other supportive evidence. 相似文献
35.
G W Moe T P Stopps C Angus C Forster A J De Bold P W Armstrong 《Journal of the American College of Cardiology》1989,13(1):173-179
The pathophysiologic role of atrial natriuretic factor and other neuroendocrine variables in relation to serum sodium and renal function was evaluated in 15 conscious dogs with severe chronic ventricular pacing-induced heart failure (250 beats/min for 5.1 +/- 0.4 weeks). Six sham-operated dogs observed over an 8 week period served as controls. Development of heart failure was characterized by a progressive increase in plasma norepinephrine, renin activity and aldosterone from control values of 293 +/- 15 pg/ml, 1.4 +/- 0.4 ng/ml per h and 124 +/- 42 pg/ml, respectively, to 1,066 +/- 96 pg/ml, 10.2 +/- 2.4 ng/ml per h and 577 +/- 151 pg/ml (all p less than 0.01), respectively, at severe heart failure. In contrast to other neuroendocrine variables, plasma atrial natriuretic factor increased from a control level of 243 +/- 74 pg/ml to a peak concentration of 724 +/- 149 pg/ml (p less than 0.01) at 2 weeks, then declined and plateaued at twice the level of the control value as severe heart failure developed. At severe heart failure, serum sodium decreased from 147 +/- 0.6 to 141.8 +/- 2.1 mmol/liter (p less than 0.05), whereas urea increased from 6.0 +/- 0.5 to 7.8 +/- 0.6 mmol/liter (p less than 0.05). The change in serum sodium concentration correlated with plasma renin activity and aldosterone (r = -0.77, -0.88, respectively, both p less than 0.01), but not with norepinephrine or atrial natriuretic factor. When sinus rhythm was restored, 14 dogs were observed for 48 to 72 h and 8 dogs were followed up for another 4 weeks after cessation of pacing.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
36.
Itzhak A. Rosner Ali D. Askari Gordon D. Mclaren Angus Muir 《The American journal of medicine》1981,70(4):870-874
A patient manifesting the arthropathy of hemochromatosis without abnormal serum iron studies is described. Hemochromatosis was confirmed by liver biopsy. This case serves to emphasize the diagnostic value of the characteristic arthropathy of hemochromatosis. Our observations in this patient support the hypothesis that the pathogenesis of hereditary hemochromatosis differs from that of acquired iron overload states. The concurrent presence of hypouricemia is explored in this patient and in 18 other patients with hereditary hemochromatosis. Men with hereditary hemochromatosis were found to have lower serum uric acid levels than expected. In our patient, a renal defect in tubular reabsorption of uric acid appears responsible for hypouricemia.The apparent association of hemochromatosis and hypouricemia deserves further investigation. 相似文献
37.
Carroll Sarah L. Clark D. Angus Hyde Luke W. Klump Kelly L. Burt S. Alexandra 《Behavior genetics》2021,51(5):580-591
Behavior Genetics - Trajectories of youth antisocial behavior (ASB) are characterized by both continuity and change. Twin studies have further indicated that genetic factors underlie continuity,... 相似文献
38.
39.
40.