全文获取类型
收费全文 | 9543篇 |
免费 | 461篇 |
国内免费 | 97篇 |
专业分类
耳鼻咽喉 | 98篇 |
儿科学 | 187篇 |
妇产科学 | 172篇 |
基础医学 | 1109篇 |
口腔科学 | 235篇 |
临床医学 | 831篇 |
内科学 | 2683篇 |
皮肤病学 | 167篇 |
神经病学 | 1056篇 |
特种医学 | 280篇 |
外科学 | 1195篇 |
综合类 | 41篇 |
预防医学 | 468篇 |
眼科学 | 110篇 |
药学 | 568篇 |
中国医学 | 44篇 |
肿瘤学 | 857篇 |
出版年
2023年 | 75篇 |
2022年 | 173篇 |
2021年 | 296篇 |
2020年 | 171篇 |
2019年 | 209篇 |
2018年 | 277篇 |
2017年 | 188篇 |
2016年 | 250篇 |
2015年 | 300篇 |
2014年 | 341篇 |
2013年 | 518篇 |
2012年 | 805篇 |
2011年 | 694篇 |
2010年 | 433篇 |
2009年 | 404篇 |
2008年 | 621篇 |
2007年 | 670篇 |
2006年 | 586篇 |
2005年 | 640篇 |
2004年 | 549篇 |
2003年 | 453篇 |
2002年 | 435篇 |
2001年 | 68篇 |
2000年 | 57篇 |
1999年 | 57篇 |
1998年 | 78篇 |
1997年 | 74篇 |
1996年 | 42篇 |
1995年 | 50篇 |
1994年 | 43篇 |
1993年 | 38篇 |
1992年 | 32篇 |
1991年 | 39篇 |
1990年 | 32篇 |
1989年 | 29篇 |
1988年 | 31篇 |
1987年 | 29篇 |
1986年 | 26篇 |
1985年 | 30篇 |
1984年 | 24篇 |
1983年 | 19篇 |
1982年 | 19篇 |
1981年 | 25篇 |
1980年 | 35篇 |
1979年 | 14篇 |
1978年 | 10篇 |
1977年 | 12篇 |
1976年 | 12篇 |
1975年 | 12篇 |
1974年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
David Brienza Ph.D. Jennifer Angelo O.T.R./L. Ph.D. Kim Henry B.S. B.S.E.E. 《Assistive technology : the official journal of RESNA》2013,25(1):55-62
A focus group comprised of persons who use power wheelchairs and professionals working in the field were asked to participate in a brainstorming session to determine priorities for the development and application of power mobility input devices and control concepts. The group consensus was that durability and reliability are the most important criteria. Essentially, the expectation is that a power wheelchair must work everyday in the way a person needs it and wants it. At the same time, there is a desire to enhance and advance the features of input devices and control systems. Many would say these changes constitute designing “smarter” power wheelchairs, such as systems that can independently detect obstacles and can provide users with more feedback. This paper presents the rationale behind forming this focus group and details of the results of a brainstorming session where ideas were generated and prioritized. The five most important issues as determined by the group are discussed in depth. 相似文献
102.
Angelo G. Rocco Vincent Chan Chris Iacobo 《Journal of pain & palliative care pharmacotherapy》2013,27(3-4):93-103
An algorithm is presented that has been developed over the past three years to provide pain relief in advanced cancer. The hospital records of 92 patients were reviewed to evaluate the validity of the algorithm. The algorithm is as follows: the 24 hour oral consumption of opioids was converted to sustained release morphine. If ineffective usually over 360?mg daily the total 24 hour oral dose was divided by 6 to convert to I.V. If this was ineffective, usually over 10?mg/hr of morphine, the intravenous dose was divided by 10 and infused epidurally. Local anesthetic was added for plexus involvement. After four days, the patient was weaned from local anesthetic solution. If sharp pain or pain to movement persisted, 6% phenol in 1 to 2?ml aliquots was injected every 8-12 hours to a total of 5-8?ml. While the conversion from intravenous to epidural morphine was 10:1 that from epidural to intravenous was only 1:3. Intravenous dose converts directly to the subcutaneous. The conversion from intravenous to oral is 1:3. There view showed that the dosages at which the conversions were made varied considerably. The reasons for the wide variation are presented. In summary the algorithm is a good practical guide for treatment of cancer pain. 相似文献
103.
Loss of inhibitory semaphorin 3A (SEMA3A) autocrine loops in bone marrow endothelial cells of patients with multiple myeloma 总被引:3,自引:0,他引:3 下载免费PDF全文
Vacca A Scavelli C Serini G Di Pietro G Cirulli T Merchionne F Ribatti D Bussolino F Guidolin D Piaggio G Bacigalupo A Dammacco F 《Blood》2006,108(5):1661-1667
Vascular endothelial growth factor165 (VEGF165) and semaphorin3A (SEMA3A) elicit pro- and antiangiogenic signals respectively in endothelial cells (ECs) by binding to their receptors VEGFR-2, neuropilin-1 (NRP1), and plexin-A1. Here we show that the VEGF165-driven angiogenic potential of multiple myeloma (MM) ECs is significantly higher than that of monoclonal gammopathy of undetermined significance (MGUS) ECs (MGECs) and human umbilical vein (HUV) ECs. This is probably due to a constitutive imbalance of endogenous VEGF165/SEMA3A ratio, which leans on VEGF165 in MMECs but on SEMA3A in MGECs and HUVECs. Exogenous VEGF165 induces SEMA3A expression in MGECs and HUVECs, but not in MMECs. Moreover, by counteracting VEGF165 activity as efficiently as an anti-VEGFR-2 antibody, exogenous SEMA3A restrains the over-angiogenic potential of MMECs. Our data indicate that loss of endothelial SEMA3A in favor of VEGF165 could be responsible for the angiogenic switch from MGUS to MM. 相似文献
104.
Francesco Scolari Elisa Delbarba Domenico Santoro Loreto Gesualdo Antonello Pani Nadia Dallera Laila-Yasmin Mani Marisa Santostefano Sandro Feriozzi Marco Quaglia Giuliano Boscutti Angelo Ferrantelli Carmelita Marcantoni Patrizia Passerini Riccardo Magistroni Federico Alberici Gian Marco Ghiggeri Claudio Ponticelli Pietro Ravani for the RI-CYCLO Investigators 《Journal of the American Society of Nephrology : JASN》2021,32(4):972
105.
Aim
To compare the value of Procalcitonin (PCT) as a marker of surgical site infection to other inflammatory markers, including C-Reactive Protein (CRP), White Cell Count (WCC) and Erythrocyte Sedimentation Rate (ESR) in patients undergoing a number of spinal procedures. This study also aims to describe the biokinetic profile of the above-named markers in patients developing surgical site infection and those remaining infection-free post-operatively.Methods
200 patients undergoing four routine elective spinal procedures were included for analysis. All patients had blood specimens taken at baseline, day 1, 2, 3, 4 and 5 post-operatively for analysis of PCT, CRP, ESR and WCC levels. All patients were monitored for early surgical site infection. Patients with other sources of infection in the early postoperative period were excluded.Results
Procalcitonin was the most sensitive and specific marker for the detection of surgical site infection in the immediate post-operative period with sensitivity and specificity of 100% and 95.2% respectively. Although Procalcitonin is an inflammatory marker, extent of surgical physiological insult did not alter its biokinetics as opposed to the other inflammatory markers making it a valuable marker of infection.Conclusion
Procalcitonin was found to be superior to the other inflammatory markers investigated in this study as a marker for early surgical site infection in patients undergoing spinal surgery. 相似文献106.
Patricia Blackburn Isabelle Lemieux Jean Bergeron Angelo Tremblay Jean-Pierre Després 《Metabolism: clinical and experimental》2009,58(8):1123-1130
The hypertriglyceridemic waist phenotype, the National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria, and the International Diabetes Federation (IDF) criteria have been proposed as screening tools to identify subjects with features of the metabolic syndrome and therefore at increased cardiometabolic risk. The aim of the present study was to compare the ability of these 3 clinical approaches to identify individuals at increased cardiometabolic risk as suggested by the presence of deteriorated markers such as hyperinsulinemia, elevated apolipoprotein B levels, small low-density lipoprotein particles, high C-reactive protein concentrations, and low adiponectin levels. For that purpose, physical and cardiometabolic characteristics of a sample of 272 white men recruited for various metabolic investigations were studied. The hypertriglyceridemic waist phenotype was defined as having both a high waist circumference (≥90 cm) and increased fasting triglyceride levels (≥2.0 mmol/L). Having at least 3 of the 5 NCEP-ATP III criteria or waist circumference of at least 94 cm plus any 2 of the 4 additional IDF criteria was also used to identify individuals at increased cardiometabolic risk. A large proportion of men with the hypertriglyceridemic waist phenotype also met the NCEP-ATP III (82.7%) or IDF (89.2%) criteria. Men with the hypertriglyceridemic waist phenotype were characterized by alterations in their lipoprotein-lipid profile that included small low-density lipoprotein particles, increased apolipoprotein B and insulin levels, as well as reduced adiponectin concentrations, which were similar to individuals meeting the NCEP-ATP III or the IDF criteria. Moreover, the Framingham risk score of men meeting any of the 3 screening tools criteria was higher and was similar across the 3 approaches (4.2, 3.8, and 3.7, respectively). These results suggest that hypertriglyceridemic waist may be as discriminant as the NCEP-ATP III or the IDF criteria and could be used as an initial screening approach to identify individuals with deteriorated cardiometabolic risk markers. 相似文献
107.
108.
109.
Perciaccante A Valente R Di Stefano A Fiorentini A Tubani L 《Blood pressure monitoring》2008,13(1):63; author reply 63-63; author reply 64
110.
Angelo A. Licata MD PhD FACP FACE 《Clinical reviews in bone and mineral metabolism》2006,4(4):305-316
Antiresorptive therapy for osteoporosis has been a mainstay during the past 50 yr. But an entirely new class of agents known
as anabolic drugs has recently been introduced. These drugs “grow new bone,” reconstitute the destroyed skeletal architecture
of osteoporosis, and thereby reduce the risk of new fractures. Teriparatide is the first such drug to fulfill these requirements,
but other agents look promising such as growth hormone and strontium renalate. On the horizon are native and analogs of parathyroid
hormone also. But these are only the beginning of a vast array of possibilities, which will arise from an understanding of
the regulatory pathways of osteoblast function. This review focuses on old and new agents, which are prospects for bone growth
based on in vivo data from human or other animal studies. It covers drugs that are in use, or nearly so, and discusses a variety
of potential target sites for future drug development. 相似文献