全文获取类型
收费全文 | 22770篇 |
免费 | 1612篇 |
国内免费 | 89篇 |
专业分类
耳鼻咽喉 | 154篇 |
儿科学 | 770篇 |
妇产科学 | 526篇 |
基础医学 | 3305篇 |
口腔科学 | 328篇 |
临床医学 | 2781篇 |
内科学 | 4999篇 |
皮肤病学 | 480篇 |
神经病学 | 2396篇 |
特种医学 | 386篇 |
外科学 | 2007篇 |
综合类 | 128篇 |
一般理论 | 28篇 |
预防医学 | 2524篇 |
眼科学 | 246篇 |
药学 | 1532篇 |
中国医学 | 43篇 |
肿瘤学 | 1838篇 |
出版年
2024年 | 20篇 |
2023年 | 215篇 |
2022年 | 387篇 |
2021年 | 763篇 |
2020年 | 509篇 |
2019年 | 759篇 |
2018年 | 784篇 |
2017年 | 576篇 |
2016年 | 651篇 |
2015年 | 713篇 |
2014年 | 909篇 |
2013年 | 1189篇 |
2012年 | 1938篇 |
2011年 | 1943篇 |
2010年 | 1036篇 |
2009年 | 872篇 |
2008年 | 1514篇 |
2007年 | 1562篇 |
2006年 | 1541篇 |
2005年 | 1423篇 |
2004年 | 1313篇 |
2003年 | 1162篇 |
2002年 | 1018篇 |
2001年 | 137篇 |
2000年 | 87篇 |
1999年 | 148篇 |
1998年 | 191篇 |
1997年 | 136篇 |
1996年 | 133篇 |
1995年 | 121篇 |
1994年 | 82篇 |
1993年 | 86篇 |
1992年 | 43篇 |
1991年 | 43篇 |
1990年 | 41篇 |
1989年 | 48篇 |
1988年 | 33篇 |
1987年 | 23篇 |
1986年 | 31篇 |
1985年 | 27篇 |
1984年 | 39篇 |
1983年 | 26篇 |
1982年 | 25篇 |
1981年 | 26篇 |
1980年 | 19篇 |
1979年 | 12篇 |
1978年 | 15篇 |
1976年 | 21篇 |
1974年 | 11篇 |
1973年 | 12篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
991.
992.
993.
994.
995.
Cedric Ghevaert Angela Rankin Elly Huiskes Leendert Porcelijn Kaija Javela Riitta Kekomaki Tamam Bakchoul Sentot Santoso Sarah Nutland Deborah J. Smyth Graham A. Smith Simon McBride Nicholas A. Watkins Willem H. Ouwehand 《Transfusion》2009,49(10):2084-2089
BACKGROUND: Maternal alloantibodies against the five common human platelet antigen (HPA) systems (HPA-1 to -3, -5, and -15) are found in only 20% of cases referred for fetal and neonatal thrombocytopenia (FMAIT) investigations. The question asked was whether mismatches for the remaining 11 low-frequency HPAs (HPA-4 and -6bw to -17bw) might in part explain the remaining 80% of cases.
STUDY DESIGN AND METHODS: A total of 1054 paternal DNA samples from referred FMAIT cases (among which 223 cases where antibodies against a common HPA were found) were genotyped for 11 low-frequency HPAs as well as a recently discovered polymorphism ( ITGA2B -C2320T). The initial genotyping was carried out by TaqMan and potential heterozygotes were confirmed by DNA sequencing. Clinical and serologic data were collected for each case with a heterozygote father.
RESULTS: In total, eight heterozygous fathers were identified: four for HPA-6w, one each for HPA-10w and -11w, and two for HPA-12w. Maternal antibodies against the corresponding antigen were identified in four of the eight cases. In two of these cases, antibodies against HPA-1a and HPA-1b were also found.
CONCLUSION: It was concluded that the minor alleles of HPA-4 and -6bw to -17bw are exceptionally rare in the Caucasian population and therefore do not explain the large number of FMAIT referrals which test negative for the common HPA antibodies. 相似文献
STUDY DESIGN AND METHODS: A total of 1054 paternal DNA samples from referred FMAIT cases (among which 223 cases where antibodies against a common HPA were found) were genotyped for 11 low-frequency HPAs as well as a recently discovered polymorphism ( ITGA2B -C2320T). The initial genotyping was carried out by TaqMan and potential heterozygotes were confirmed by DNA sequencing. Clinical and serologic data were collected for each case with a heterozygote father.
RESULTS: In total, eight heterozygous fathers were identified: four for HPA-6w, one each for HPA-10w and -11w, and two for HPA-12w. Maternal antibodies against the corresponding antigen were identified in four of the eight cases. In two of these cases, antibodies against HPA-1a and HPA-1b were also found.
CONCLUSION: It was concluded that the minor alleles of HPA-4 and -6bw to -17bw are exceptionally rare in the Caucasian population and therefore do not explain the large number of FMAIT referrals which test negative for the common HPA antibodies. 相似文献
996.
Red Wine Polyphenols Prevent Metabolic and Cardiovascular Alterations Associated with Obesity in Zucker Fatty Rats (Fa/Fa) 下载免费PDF全文
997.
Martha Q. Lacy Sumithra Mandrekar Angela Dispenzieri Suzanne Hayman Shaji Kumar Francis Buadi David Dingli Mark Litzow Peter Wettstein Douglas Padley Brian Kabat Dennis Gastineau S. Vincent Rajkumar Morie A. Gertz 《American journal of hematology》2009,84(12):799-802
Vaccines are attractive as consolidation therapy after autologous stem cell transplantation (ASCT) for multiple myeloma (MM). We report the results of a phase II trial of the immunotherapeutic, APC8020 (Mylovenge?), given after ASCT for MM. We compared the results with that of other patients with MM who underwent ASCT at Mayo Clinic during the same time period. Twenty‐seven patients were enrolled on the trial between July, 1998 and June, 2001, and the outcomes were compared to that of 124 consecutive patients transplanted during the same period, but not enrolled on the trial. The median (range) follow‐up for patients still alive from the vaccine trial is 6.5 (2.9–8 years), and 7.1 (6–8 years) in the control group. The median age was 57.4 range (36.1–71.3) in the DB group and 56.4 (range, 30–69) in the trial group. Known prognostic factors including PCLI, B2M, and CRP were comparable between the groups. The median overall survival for the trial patients was 5.3 years (95% CI: 4.0 years—N/A) compared to 3.4 years (95% CI: 2.7–4.6 years) for the DB group (P = 0.02). The median time to progression and progression‐free survival for the trial group was similar to the DB group. Although not a controlled trial, the vaccines given after ASCT appear to be associated with improved overall survival compared to historical controls. This approach warrants further investigation to confirm this and define the role of vaccine therapy in myeloma. Am. J. Hematol. 2009. © 2009 Wiley‐Liss, Inc. 相似文献
998.
Angela van Baardwijk Geert Bosmans Robert Jan van Suylen Marinus van Kroonenburgh Monique Hochstenbag Gijs Geskes Philippe Lambin Dirk De Ruysscher 《Radiotherapy and oncology》2008,87(1):55-58
We evaluated the feasibility to correlate intra-tumour heterogeneity as visualized on 18F-FDG PET with histology for NSCLC. For this purpose we used an ex-vivo model. The procedure was feasible in all operated patients. We have shown that this method is suitable for correlating intra-tumour heterogeneity in tracer uptake with histology. 相似文献
999.
1000.
Lack of effect modification between estrogen metabolism genotypes and combined hormone replacement therapy in postmenopausal breast cancer risk. 总被引:1,自引:0,他引:1