全文获取类型
收费全文 | 80564篇 |
免费 | 6180篇 |
国内免费 | 261篇 |
专业分类
耳鼻咽喉 | 958篇 |
儿科学 | 2108篇 |
妇产科学 | 1102篇 |
基础医学 | 10962篇 |
口腔科学 | 858篇 |
临床医学 | 8564篇 |
内科学 | 17262篇 |
皮肤病学 | 894篇 |
神经病学 | 7843篇 |
特种医学 | 3131篇 |
外科学 | 13044篇 |
综合类 | 968篇 |
一般理论 | 91篇 |
预防医学 | 6032篇 |
眼科学 | 1991篇 |
药学 | 5430篇 |
中国医学 | 95篇 |
肿瘤学 | 5672篇 |
出版年
2023年 | 610篇 |
2022年 | 884篇 |
2021年 | 2425篇 |
2020年 | 1373篇 |
2019年 | 2222篇 |
2018年 | 2544篇 |
2017年 | 1821篇 |
2016年 | 1909篇 |
2015年 | 2233篇 |
2014年 | 3239篇 |
2013年 | 4099篇 |
2012年 | 6580篇 |
2011年 | 6810篇 |
2010年 | 3728篇 |
2009年 | 3293篇 |
2008年 | 5465篇 |
2007年 | 5682篇 |
2006年 | 5234篇 |
2005年 | 5195篇 |
2004年 | 4715篇 |
2003年 | 4327篇 |
2002年 | 3924篇 |
2001年 | 638篇 |
2000年 | 448篇 |
1999年 | 612篇 |
1998年 | 811篇 |
1997年 | 610篇 |
1996年 | 496篇 |
1995年 | 444篇 |
1994年 | 415篇 |
1993年 | 407篇 |
1992年 | 272篇 |
1991年 | 227篇 |
1990年 | 201篇 |
1989年 | 182篇 |
1988年 | 172篇 |
1987年 | 163篇 |
1986年 | 150篇 |
1985年 | 173篇 |
1984年 | 199篇 |
1983年 | 169篇 |
1982年 | 245篇 |
1981年 | 240篇 |
1980年 | 171篇 |
1979年 | 111篇 |
1978年 | 124篇 |
1977年 | 114篇 |
1976年 | 78篇 |
1975年 | 65篇 |
1974年 | 64篇 |
排序方式: 共有10000条查询结果,搜索用时 187 毫秒
991.
992.
993.
Andrew R. Lavik Fei Zhong Ming-Jin Chang Edward Greenberg Yuvraj Choudhary Mitchell R. Smith Karen S. McColl John Pink Frederic J. Reu Shigemi Matsuyama Clark W. Distelhorst 《Oncotarget》2015,6(29):27388-27402
Bcl-2 inhibits apoptosis by two distinct mechanisms but only one is targeted to treat Bcl-2-positive malignancies. In this mechanism, the BH1-3 domains of Bcl-2 form a hydrophobic pocket, binding and inhibiting pro-apoptotic proteins, including Bim. In the other mechanism, the BH4 domain mediates interaction of Bcl-2 with inositol 1,4, 5-trisphosphate receptors (IP3Rs), inhibiting pro-apoptotic Ca2+ signals. The current anti-Bcl-2 agents, ABT-263 (Navitoclax) and ABT-199 (Venetoclax), induce apoptosis by displacing pro-apoptotic proteins from the hydrophobic pocket, but do not inhibit Bcl-2-IP3R interaction. Therefore, to target this interaction we developed BIRD-2 (Bcl-2 IP3 Receptor Disruptor-2), a decoy peptide that binds to the BH4 domain, blocking Bcl-2-IP3R interaction and thus inducing Ca2+-mediated apoptosis in chronic lymphocytic leukemia, multiple myeloma, and follicular lymphoma cells, including cells resistant to ABT-263, ABT-199, or the Bruton’s tyrosine kinase inhibitor Ibrutinib. Moreover, combining BIRD-2 with ABT-263 or ABT-199 enhances apoptosis induction compared to single agent treatment. Overall, these findings provide strong rationale for developing novel therapeutic agents that mimic the action of BIRD-2 in targeting the BH4 domain of Bcl-2 and disrupting Bcl-2-IP3R interaction. 相似文献
994.
Andrea Altschuler Elana Rosenbaum Peter Gordon Sandra Canales Andrew L. Avins 《Supportive care in cancer》2012,20(6):1291-1297
Purpose
Mindfulness-based stress reduction (MBSR), typically taught in eight weekly classes, helps patients cope with illness, including cancer. Current research is almost exclusively based on post-treatment class attendance. Research suggests that short courses and alternative delivery techniques may also be beneficial. This pilot study assessed whether it would be feasible for cancer patients receiving chemotherapy to listen to MBSR audio recordings individually during treatment and at home and evaluate whether the intervention shows preliminary evidence of efficacy to improve patients’ mood and quality of life (QoL). 相似文献995.
Victoria L. Sibson Carlos S. Grijalva‐Eternod Garba Noura Julia Lewis Kwanli Kladstrup Hassan Haghparast‐Bidgoli Jolene Skordis‐Worrall Tim Colbourn Joanna Morrison Andrew J. Seal 《Maternal & child nutrition》2018,14(4)
Unconditional cash transfers (UCTs) are used as a humanitarian intervention to prevent acute malnutrition, despite a lack of evidence about their effectiveness. In Niger, UCT and supplementary feeding are given during the June–September “lean season,” although admissions of malnourished children to feeding programmes may rise from March/April. We hypothesised that earlier initiation of the UCT would reduce the prevalence of global acute malnutrition (GAM) in children 6–59 months old in beneficiary households and at population level. We conducted a 2‐armed cluster‐randomised controlled trial in which the poorest households received either the standard UCT (4 transfers between June and September) or a modified UCT (6 transfers from April); both providing 130,000 FCFA/£144 in total. Eligible individuals (pregnant and lactating women and children 6–<24 months old) in beneficiary households in both arms also received supplementary food between June and September. We collected data in March/April and October/November 2015. The modified UCT plus 4 months supplementary feeding did not reduce the prevalence of GAM compared with the standard UCT plus 4 months supplementary feeding (adjusted odds ratios 1.09 (95% CI [0.77, 1.55], p = 0.630) and 0.93 (95% CI [0.58, 1.49], p = 0.759) among beneficiaries and the population, respectively). More beneficiaries receiving the modified UCT plus supplementary feeding reported adequate food access in April and May (p < 0.001) but there was no difference in endline food security between arms. In both arms and samples, the baseline prevalence of GAM remained elevated at endline (p > 0.05), despite improved food security (p < 0.05), possibly driven by increased fever/malaria in children (p < 0.001). Nonfood related drivers of malnutrition, such as disease, may limit the effectiveness of UCTs plus supplementary feeding to prevent malnutrition in this context. Caution is required in applying the findings of this study to periods of severe food insecurity. 相似文献
996.
997.
998.
James E. Andruchow Peter A. Kavsak Andrew D. McRae 《The Canadian journal of cardiology》2018,34(2):98-108
This article synthesizes current best evidence for the evaluation of patients with suspected acute coronary syndrome (ACS) using high-sensitivity troponin assays, enabling physicians to effectively incorporate them into practice. Unlike conventional assays, high-sensitivity assays can precisely measure blood cardiac troponin concentrations in the vast majority of healthy individuals, facilitating the creation of rapid diagnostic algorithms. Very low troponin concentrations on presentation accurately rule out acute myocardial infarction (AMI) and enable the discharge of approximately 20% of patients after a single test, whereas an additional 30%-40% of patients can be safely discharged after short-interval serial sampling in as little as 1 or 2 hours. In contrast, highly abnormal troponin concentrations on presentation (more than 5 times the upper reference limit) or rapidly rising levels on serial testing can rapidly rule in AMI with high specificity. However, approximately one-third of patients remain in a biomarker-indeterminate “observation zone” even after serial sampling. These patients pose a disposition challenge to clinicians because although the differential diagnosis of elevated troponin concentrations is broad, these patients have an increased risk for short-term major adverse cardiac events. Use of repeated serial troponin sampling and structured clinical prediction tools may assist disposition for these patients, because no validated pathways currently exist to guide clinicians. Ongoing research to tailor diagnostic thresholds to individual patient characteristics may enable improved diagnostic accuracy and usher in a new era of personalized medicine in the evaluation of suspected ACS. 相似文献
999.
Linda M. Ercoli Steven A. Castellon Aimee M. Hunter Lorna Kwan Barbara A. Kahn-Mills Paul A. Cernin Andrew F. Leuchter Patricia A. Ganz 《Brain imaging and behavior》2013,7(4):543-553
To assess the feasibility of a cognitive rehabilitation program in breast cancer survivors (BCS) with persistent post-treatment cognitive complaints. BCS with cognitive complaints, 18-months to 5-years post-treatment, were recruited for a once-weekly, five-week, group cognitive training intervention. Outcome measures included self-reported mood and cognitive function, and neurocognitive tests administered at pre-intervention, immediate-, two-month and four-month post-intervention. A sub-study in eight participants evaluated resting state quantitative electroencephalography (qEEG) changes from pre- to immediate post-intervention in relationship to post-intervention changes in cognitive complaints. Twenty-seven BCS completed the protocol and tolerated the intervention well. We observed significant reductions in total and memory-specific cognitive complaints from pre-intervention to immediate post-intervention (p?=?0.031 and p?=?0.009, respectively) and at four-months post-intervention (p?<?0.0001 and p?<?0.001, respectively). Significant improvement in neurocognitive tests were found for Symbol Digit, Stroop, and Trails A tests (df?=?26, all p’s <0.05). Effect sizes for changes from pre-intervention to immediate and to four-month post intervention ranged from 0.429 to 0.607, and from 0.439 to 0.741, respectively. Increase in qEEG absolute alpha power over the course of the intervention was associated with reduced complaints at immediate post-intervention (r?=??0.78, p?=?0.021), two-months (r range?=??0.76 to ?0.82, p-value range 0.004 to 0.03), and four-months (r?=??0.71, p?=?0.048). A five-week group cognitive training intervention is feasible and well tolerated. Cognitive complaints and neurocognitive test performances showed positive changes. qEEG may serve as a potential biomarker for improvement in self-reported complaints. A randomized clinical trial is underway to test the efficacy of the intervention. 相似文献
1000.