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981.
Keat Choong MBChB Nathan J Walker MBBS Andrew JG Apel FRANZCO Michael Whitby FRACP 《Clinical & experimental ophthalmology》2010,38(3):309-313
Herpes simplex virus (HSV) keratitis is a common cause of ocular morbidity. Resistance to aciclovir is probably under recognized. We describe three cases of aciclovir‐resistant herpes simplex virus keratitis treated with systemic foscarnet and present a review of the pharmacological options available to manage this condition. 相似文献
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B. Kanthimathi S. Udhaya Shankar K. Arun Kumar V. L. Narayanan 《Clinics in Orthopedic Surgery》2014,6(4):480-483
Myositis ossificans traumatica is an unusual complication following a muscle contusion injury. A significantly large myositic mass causing ankylosis of the elbow is even rarer. We report a 13-year-old boy who presented with a 14-month history of a fixed elbow with no movement and a palpable bony mass in the anterior aspect of the elbow. He had sustained significant trauma to the affected limb 1 month prior to onset of symptoms, which was managed by native massage and bandaging for 4 weeks. The clinicoradiological diagnosis was suggestive of myositis ossificans, and the myositic mass was completely excised. Histopathology revealed lamellar bone. The 2-year follow-up showed full function of the affected limb and no signs of recurrence. We report this case of clinical interest due to the unusually large myositic mass. 相似文献
986.
Christopher Gomez Shivank Bhatia Francisco Cesar Carnevale Govindarajan Narayanan 《Journal of vascular and interventional radiology : JVIR》2017,28(1):126-133
Urodynamic testing is the most accurate representation of bladder outlet obstruction physiology. As prostate artery embolization becomes an increasingly common therapy for benign prostatic obstruction, knowledge of urodynamic assessment and reports can assist the interventional radiologist in selecting appropriate patients. This review summarizes the role of urodynamic studies in the management of benign prostatic obstruction, including patient selection, interpretation of urodynamic studies, and their potential to predict patient outcomes. 相似文献
987.
Evaluating the Predictivity of Virtual Screening for Abl Kinase Inhibitors to Hinder Drug Resistance
Osman A. B. S. M. Gani Dilip Narayanan Richard A. Engh 《Chemical biology & drug design》2013,82(5):506-519
Virtual screening methods are now widely used in early stages of drug discovery, aiming to rank potential inhibitors. However, any practical ligand set (of active or inactive compounds) chosen for deriving new virtual screening approaches cannot fully represent all relevant chemical space for potential new compounds. In this study, we have taken a retrospective approach to evaluate virtual screening methods for the leukemia target kinase ABL1 and its drug‐resistant mutant ABL1‐T315I. ‘Dual active’ inhibitors against both targets were grouped together with inactive ligands chosen from different decoy sets and tested with virtual screening approaches with and without explicit use of target structures (docking). We show how various scoring functions and choice of inactive ligand sets influence overall and early enrichment of the libraries. Although ligand‐based methods, for example principal component analyses of chemical properties, can distinguish some decoy sets from active compounds, the addition of target structural information via docking improves enrichment, and explicit consideration of multiple target conformations (i.e. types I and II) achieves best enrichment of active versus inactive ligands, even without assuming knowledge of the binding mode. We believe that this study can be extended to other therapeutically important kinases in prospective virtual screening studies. 相似文献
988.
Jerene Mathews Jahangir Ahmed Naseem Nischal Neupane Narayanan Parameswaran Laxmisha Chandrashekar 《Pediatric dermatology》2019,36(5):735-736
Skin lesions in early congenital syphilis can show considerable variability. A 35‐day‐old infant presented with rhinitis, desquamation of palms and soles, pseudoparalysis of the right upper limb, and annular lesions with peripheral blistering over the chest and abdomen, resembling a “string‐of‐pearls.” A diagnosis of congenital syphilis was made on the basis of radiologic evaluation and reactive Venereal Disease Research Laboratory (VDRL) in both mother and child. We report this case to highlight the unusual presentation of congenital syphilis with annular configuration of blisters, mimicking a “string‐of‐pearls." 相似文献
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990.
Khalid Hindi Sarmad Alazzawi Rajagopalan Raman Narayanan Prepageran Kartini Rahmat 《Indian journal of otolaryngology and head and neck surgery》2014,66(4):429-436
The aim of this study is to assess the pneumatization of the paranasal sinuses (PNS) and other parts of temporal bone such as mastoid air cells and to investigate if there was any association between the aeration of these structures among the three major ethnic groups in Malaysia (Malay, Chinese, Indian) as this would be representative of Asia. A retrospective review of 150 computed tomography (CT) scans of PNS and temporal bones was done and analysed. The pneumatization of each area was obtained and compared using statistical analysis. Patients with a history of previous medical or surgical problems in the intended areas were excluded from the study. The pneumatization of the mastoid air cells and other temporal bone parts were noted to be symmetrical in more than 75 %. There was a positive correlation between the pneumatization of mastoid air cells and that of the sphenoid sinus. The prevalence of Agger nasi, Haller’s and Onodi cells was observed to be significantly higher in the Chinese group. Preoperative assessment of the temporal bone and PNS with CT scan may be helpful in the evaluation of their anatomical landmark and decrease the possibility of surgical complications related to 3D structures. 相似文献