全文获取类型
收费全文 | 1371篇 |
免费 | 65篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 26篇 |
儿科学 | 63篇 |
妇产科学 | 20篇 |
基础医学 | 126篇 |
口腔科学 | 44篇 |
临床医学 | 129篇 |
内科学 | 365篇 |
皮肤病学 | 110篇 |
神经病学 | 41篇 |
特种医学 | 207篇 |
外科学 | 127篇 |
综合类 | 29篇 |
预防医学 | 83篇 |
眼科学 | 6篇 |
药学 | 40篇 |
中国医学 | 3篇 |
肿瘤学 | 50篇 |
出版年
2019年 | 9篇 |
2018年 | 8篇 |
2017年 | 12篇 |
2016年 | 16篇 |
2015年 | 24篇 |
2014年 | 25篇 |
2013年 | 68篇 |
2012年 | 17篇 |
2011年 | 17篇 |
2010年 | 48篇 |
2009年 | 59篇 |
2008年 | 25篇 |
2007年 | 33篇 |
2006年 | 27篇 |
2005年 | 32篇 |
2004年 | 16篇 |
2003年 | 15篇 |
2002年 | 22篇 |
2001年 | 21篇 |
2000年 | 12篇 |
1999年 | 20篇 |
1998年 | 84篇 |
1997年 | 74篇 |
1996年 | 77篇 |
1995年 | 49篇 |
1994年 | 63篇 |
1993年 | 51篇 |
1992年 | 16篇 |
1991年 | 16篇 |
1990年 | 26篇 |
1989年 | 47篇 |
1988年 | 44篇 |
1987年 | 34篇 |
1986年 | 30篇 |
1985年 | 30篇 |
1984年 | 31篇 |
1983年 | 15篇 |
1982年 | 21篇 |
1981年 | 18篇 |
1980年 | 13篇 |
1979年 | 18篇 |
1978年 | 14篇 |
1977年 | 17篇 |
1976年 | 17篇 |
1975年 | 12篇 |
1974年 | 8篇 |
1973年 | 14篇 |
1972年 | 12篇 |
1971年 | 7篇 |
1957年 | 7篇 |
排序方式: 共有1469条查询结果,搜索用时 15 毫秒
41.
42.
Ileocecal Tuberculosis 总被引:1,自引:0,他引:1
R. E. BONDURANT LCdr MC USN D. REID Capt MC USN 《The American journal of gastroenterology》1975,63(1):58-64
Three cases of ileocecal tuberculosis are presented with a review of pathogenesis, diagnosis and therapy.
Emphasis is placed upon preoperative suspicion and the indications for resectional surgery in combination with antituberculous drugs in the management of the patients. 相似文献
Emphasis is placed upon preoperative suspicion and the indications for resectional surgery in combination with antituberculous drugs in the management of the patients. 相似文献
43.
Adverse effects of the transfusion of homologous blood on tumor recurrence and resistance to bacterial infection have been reported previously, but the findings are inconclusive. A retrospective review of patients undergoing orthopedic surgery was conducted, and the rate of the postoperative infectious complications was compared among those receiving homologous blood, autologous blood, both types, or no transfusion support. An overall postoperative infection rate of 6.1 percent was observed: 6.9 percent among persons receiving homologous blood, 5.0 percent among those receiving autologous blood, 11.9 percent among those receiving both homologous and autologous blood, and 4.9 percent among those not receiving transfusions (p = 0.37). Among patients receiving homologous blood, a subset of 15 patients received homologous whole blood and had an infection rate of 20 percent. Significant predictors of postoperative infection included increasing age, spinal surgery, high admission hematocrit, and greater time in surgery. Of factors relating to transfusion, only the use of homologous whole blood was a significant predictor of postoperative infection, which suggests a detrimental effect of homologous plasma. It can be concluded that, in this group of patients undergoing relatively nontraumatic surgery, several variables that are not related to transfusion, as well as the use of homologous whole blood, were significant predictors of postoperative infection. 相似文献
44.
B. H. Sullivan Jr. COL. MC U. S. ARMY Nelson S. Irey LT. COL. MC U. S. ARMY Vincent J. Pileggi ST LT. MSC U. S. ARMY Richard I. Crone COL. MC U. S. ARMY John R. Gibson LT. COL. MC U. S. ARMY 《Digestive diseases and sciences》1957,2(4):210-223
Summary 1. Twenty-two patients with infectious mononucleosis were studied by liver biopsy and paper electrophoresis of the serum proteins. The findings were compared with a similar group of 30 patients with infectious hepatitis.2. The essential histologic features of infectious mononucleosis were the presence in the hepatic sinusoids and portal tracts of chronic inflammatory cells resembling small lymphocytes, with essentially no parenchymal cell damage. Admixed with this lymphocytic infiltrate, but in relatively minimal numbers, were a few plasma cells and polymorphonuclear leukocytes. In addition, in infectious mononucleosis there were, with rare exceptions, no lipochrome-containing Kupffer cells. Thus, in the majority of cases, the histologic picture was distinct from that seen in infectious hepatitis. Only in comparing a few of the more severe infectious mononucleosis cases with subsiding infectious hepatitis cases was there any tendency for the two pictures to merge, and the distinction on histologic grounds between the two entities could be made in the great majority of cases.3. The most commonly seen abnormalities in the paper electrophoretic patterns of sera obtained from patients with infectious mononucleosis were decreased albumin, increased gamma globulin, not infrequent but variable changes in alpha2 globulin, and the presence of abnormal proteins migrating with mobilities intermediate to alpha2 and beta, and beta and gamma globulins. The abnormalities observed in infectious hepatitis were similar to those of infectious mononucleosis, except that in hepatitis alpha2 globulin was decreased more consistently, gamma globulin increased less frequently, and beta globulin, which was normal in practically all the cases of infectious mononucleosis, was increased in a considerable number of cases.4. Treatment of patients with infectious mononucleosis need not include prolonged bed rest and restriction of activity in an effort to avoid the development of chronic liver disease. 相似文献
45.
P. H. Sebrechts CAPT MC USN J. P. Anderson Jr. LCDR MC USN 《Diseases of the colon and rectum》1971,14(1):57-61
Summary The management of pilonidal cyst disease in a large military hospital is described. Of special interest to the military practice
is the “buddy” system, in which patients help one another to keep their wounds clean and dry. The specific objectives of our
technic are: 1) obtaining excellent hemostasis by the use of zinc peroxide paste; 2) avoiding recurrences by an open-wound
method of treatment; 3) preservation of a pad of subcutaneous tissue over the postsacral fascia, thus reducing long-term morbidity
by insuring a mobile scar; 4) decreasing the duration of hospitalization, achieved by frequently drying the wounds with warm
air.
Read at the meeting of the American Proctologic Society, Hollywood, Florida, April 12 to 16, 1970.
The opinions or assertions contained herein are those of the authors and are not to be construed as official or as reflecting
the views of the Navy Department. 相似文献
46.
47.
48.
Canfield MC; Tamarappoo BK; Moses AM; Verkman AS; Holtzman EJ 《Human molecular genetics》1997,6(11):1865-1871
Congenital nephrogenic diabetes insipidus (NDI) is a rare disease caused
most often by mutations in the vasopressin V2 receptor (AVPR2). We studied
a family which included a female patient with NDI with symptoms dating from
infancy. The patient responded to large doses of desmopressin (dDAVP) which
decreased urine volume from 10 to 4 I/day. Neither the parents nor the
three sisters were polyuric. The patient was found to be a compound
heterozygote for two novel recessive point mutations in the aquaporin-2
(AQP2) gene: L22V in exon 1 and C181W in exon 3. Residue Cys181 in AQP2 is
the site for inhibition of water permeation by mercurial compounds and is
located near to the NPA motif conserved in all aquaporins. Osmotic water
permeability (Pf) in Xenopus oocytes injected with cRNA encoding C181W-AQP2
was not increased over water control, while expression of L22V cRNA
increased the Pf to approximately 60% of that for wild-type AQP2.
Co-injection of the mutant cRNAs with the wild-type cRNA did not affect the
function of the wild-type AQP2. Immunolocalization of AQP2-transfected CHO
cells showed that the C181W mutant had an endoplasmic reticulum-like
intracellular distribution, whereas L22V and wild-type AQP2 showed endosome
and plasma membrane staining. Water permeability assays showed a high Pf in
cells expressing wild-type and L22V AQP2. This study indicates that AQP2
mutations can confer partially responsive NDI.
相似文献
49.
The role of size, sequence and haplotype in the stability of FRAXA and FRAXE alleles during transmission 总被引:2,自引:5,他引:2
Murray A; Macpherson JN; Pound MC; Sharrock A; Youings SA; Dennis NR; McKechnie N; Linehan P; Morton NE; Jacobs PA 《Human molecular genetics》1997,6(2):173-184
Factors involved in the stability of trinucleotide repeats during
transmission were studied in 139 families in which a full mutation,
premutation or intermediate allele at either FRAXA or FRAXE was
segregating. The transmission of alleles at FRAXA, FRAXE and four
microsatellite loci were recorded for all individuals. Instability within
the minimal and common ranges (0-40 repeats for FRAXA, 0-30 repeats for
FRAXE) was extremely rare; only one example was observed, an increased in
size at FRAXA from 29 to 39 repeats. Four FRAXA and three FRAXE alleles in
the intermediate range (41-60) repeats for FRAXA, 31-60 for FRAXE) were
unstably transmitted. Instability was more frequent for FRAXA intermediate
alleles that had a tract of pure CGG greater than 37 although instability
only occurred in two of 13 such transmissions: the changes observed were
limited to only one or two repeats. Premutation FRAXA alleles over 100
repeats expanded to a full mutation during female transmission in 100% of
cases, in agreement with other published series. There was no clear
correlation between haplotype and probability of expansion of FRAXA
premutations. Instability at FRAXA or FRAXE was more often observed in
conjunction with a second instability at an independent locus suggesting
genomic instability as a possible mechanism by which at least some FRAXA
and FRAXE mutations arise.
相似文献
50.
Is the outcome of in-vitro fertilization and embryo transfer treatment improved by spontaneous or surgical drainage of a hydrosalpinx? 总被引:4,自引:7,他引:4
Sowter MC; Akande VA; Williams JA; Hull MG 《Human reproduction (Oxford, England)》1997,12(10):2147-2150
A pilot study was designed to examine whether the outcome of embryo
transfer in women with a hydrosalpinx might be improved by surgical
drainage of the hydrosalpinx at the time of oocyte collection for in- vitro
fertilization treatment. A comparative, controlled but retrospective
analysis of the results was performed of all women with infective tubal
damage aged <40 years old, who had ovulatory cycles, a normal uterus and
a partner with normal spermatozoa. A standardized treatment regimen was
used. A maximum of three embryos were transferred. Hydrosalpinx was defined
by prior hysterosalpingography and/or laparoscopy with transcervical dye
injection. A total of 237 embryo transfer cycles in women with
hydrosalpinges (tubal distension not visible in 151, visible but not
drained in 30 and drained in 56) were compared with 705 embryo transfer
cycles in women with tubal disease but no hydrosalpinx. Results were
analysed in the first three cycles but also separately in the first cycle
to check for bias. Success rates were higher in the first cycle, but did
not significantly influence overall differences. Implantation rates were
significantly reduced overall in the hydrosalpinx group (8.0 versus 13.2%
for controls; P < 0.001), being 8.3% (P < 0.01) in the subgroup
without evident tubal distension and 7.5% (not significant) in the drained
hydrosalpinx group. This study shows that tubal damage with distal
occlusion is associated with a marked reduction in embryo implantation,
even in the absence of obvious fluid distension. Surgical drainage of
distended hydrosalpinges appears to offer no benefit.
相似文献