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51.
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Aiyer HS Li Y Losso JN Gao C Schiffman SC Slone SP Martin RC 《Nutrition and cancer》2011,63(8):1256-1262
The incidence of esophageal adenocarcinoma in humans is increasing more rapidly than any other malignancy in the United States. Animal studies have demonstrated the efficacy of freeze-dried berry supplementation on carcinogen-induced esophageal squamous cell carcinoma in rats; however, no such studies have been done in esophagoduodenal anastomosis (EDA), an animal model for reflux-induced esophageal adenocarcinoma (EAC) development. Eight-week-old male Sprague-Dawley rats were randomized into 3 groups: EDA + control diet (EDA-CD; n = 10); EDA + 2.5% black raspberry diet (EDA-BRB; n = 11) and EDA + 2.5% blueberry diet (EDA-BB; n = 12). After 2 wk of feeding the respective diets, the rats underwent EDA surgery to induce gastroesophageal reflux and then continued the diet. Measurement of feed intake suggested that all EDA-operated animals had lower feed intake starting at 10 wk after surgery and this was significant close to termination at 24 wk. There were no significant differences in either reflux esophagitis (RE), intestinal metaplasia (IM) (70% in CD, 64% in BRB, and 66% in BB; P = 0.1) or EAC incidence (30% for CD, 34% for BRB, and 25% for BB; P = 0.2) with supplementation. Berry diets did not alter COX-2 levels, but BB diet significantly reduced MnSOD levels (1.23 ± 0.2) compared to control diet (2.05 ± 0.14; P < 0.05). We conclude that a dietary supplementation of freeze-dried BRB and BB at 2.5% (w/w) was not effective in the prevention of reflux-induced esophageal adenocarcinoma in this EDA animal model. 相似文献
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R. G. Aiyer Bhavin Parikh 《Indian journal of otolaryngology and head and neck surgery》2009,61(1):47-53
Auditory brainstem responses (ABR) were recorded in 30 normal and 60 high-risk neonates with gestational age between 30 and
45 weeks. The normative data of normal group as regard to age, sex and various parameters of ABR were compared with high-risk
group. ABR parameters especially wave V and interwave V-I intervals were significantly prolonged in high-risk infants. An
infant was considered to “pass” the ABR test if an identifiable and replicable wave V response was present at 30 dB HL in
both ears. All the normal neonates had click thresholds consistent with normal hearing. 12 of the highrisk neonates showed
mild to moderate hearing impairment (absent replicable wave V at 30–60 dB HL) and 2 of them showed severe to profound hearing
impairment (absent replicable wave V at 70 dB HL). 9 of the “failed” group were reevaluated within 3 months and several times
thereafter if the abnormal responses persisted. 2 (3.3%) infants showed persistent hearing loss, which was confirmed later
by behavioral audiometry. 相似文献
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A. A. Desai R. G. Aiyer V. K. Pandya Unnikrishnan Nair 《Indian journal of otolaryngology and head and neck surgery》2004,56(3):240-242
Mild Sensorineural hearing loss subsequent to middle ear surgery has till today been an important complication to middle ear
surgery inspite of advances in surgical techniques, operative instruments, monitoring devices and better treatment options.
Lack of proper knowledge about this problem is because of under reporting of exact magnitude of hearing loss on account of
difficulty in measuring hearing threshold of patients in immediate postoperative period as it may lead to post operative infection
and discomfort to the patient.
In our study of 80 cases carried out at ENT department, Baroda Medical College and S.S.G Hospital, Baroda, we have utilized
weber’s lateralisation principle and measured bone conduction thresholds of patients undergoing middle ear surgery for evaluation
of postoperative Sensorineural loss as a result of middle ear surgery. Probable causes of post operative hearing loss in a
patient undergoing middle ear surgery are, noise due to drills, continuous suction irrigation, vibrations, inner ear injury,
manipulation of ossicles and a few unknown reasons. 相似文献
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I Halder KE Kip SR Mulukutla AN Aiyer OC Marroquin GS Huggins SE Reis 《American journal of epidemiology》2012,176(2):146-155
Large epidemiologic studies examining differences in cardiovascular disease (CVD) risk factor profiles between European Americans and African Americans have exclusively used self-identified race (SIR) to classify individuals. Recent genetic epidemiology studies of some CVD risk factors have suggested that biogeographic ancestry (BGA) may be a better predictor of CVD risk than SIR. This hypothesis was investigated in 464 African Americans and 771 European Americans enrolled in the Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) Study in March and April 2010. Individual West African and European BGA were ascertained by means of a panel of 1,595 genetic ancestry informative markers. Individual BGA varied significantly among African Americans and to a lesser extent among European Americans. In the total cohort, BGA was not found to be a better predictor of CVD risk factors than SIR. Both measures predicted differences in the presence of the metabolic syndrome, waist circumference, triglycerides, body mass index, very low density lipoprotein cholesterol, lipoprotein A, and systolic and diastolic blood pressure between European Americans and African Americans. These results suggest that for most nongenetic cardiovascular epidemiology studies, SIR is sufficient for predicting CVD risk factor differences between European Americans and African Americans. However, higher body mass index and diastolic blood pressure were significantly associated with West African BGA among African Americans, suggesting that BGA should be considered in genetic cardiovascular epidemiology studies carried out among African Americans. 相似文献
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Amiethab Aiyer William Hennrikus Jessica Walrath Brandt Groh Barbara Ostrov 《Journal of children's orthopaedics》2014,8(4):359-365