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51.
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Chen YB Aldridge J Kim HT Ballen KK Cutler C Kao G Liney D Bourdeau G Alyea EP Armand P Koreth J Ritz J Spitzer TR Soiffer RJ Antin JH Ho VT 《Biology of blood and marrow transplantation》2012,18(5):805-812
There are little data comparing umbilical cord blood (UBC) and conventional stem cell sources for reduced-intensity conditioning (RIC) hematopoietic stem cell transplantation (HSCT). We performed a retrospective analysis of RIC HCST using double UCB (dUCB) grafts and RIC HSCT using unrelated donor (URD) grafts. The study included 64 dUCB transplantations and 221 URD transplantations performed at Dana-Farber Cancer Institute and Massachusetts General Hospital between 2004 and 2008. The cumulative incidence of grade II-IV acute graft-versus-host disease (GVHD) was 14.1% for dUCB and 20.3% for URD (P = .32). The 2-year cumulative incidence of chronic GVHD was significantly lower in dUCB compared with URD (21.9% versus 53.9%; P < .0001). The 2-year cumulative incidence of nonrelapse mortality was significantly higher in dUCB (26.9% versus 10.4%; P = .0009). In our analysis, dUCB HSCT and URD HSCT had comparable 3-year overall survival (46% in dUCB and 50% in URD; P = .49) and progression-free survival (30% in dUCB and 40% in URD; P = .47). dUCBT was associated with greater nonrelapse mortality despite less chronic GVHD. Our findings suggest that the use of 2 partially matched UCB units appears to be a suitable alternative for patients undergoing RIC HSCT without an HLA-matched donor. 相似文献
53.
Radiology conferences enable participants the opportunity to ask experts questions through question and answer (Q and A) sessions
or individually. Given the time limitations and intimidating circumstances, we incorporated conference text messaging (confexting)
as a method of increasing interactivity between the audience and speakers. During a 5-day radiology conference, text messaging
was utilized for anonymous interactivity between the audience and speakers during Q and A sessions. There were 324 text messages;
76 of these were either follow-up statements or questions related to earlier text messages. Forty-two questions were submitted
via paper notes. There was a general trend of an increasing number of text messages and a decreasing number of paper notes.
The anonymous text messaging system was found to be an effective method for interactivity between the audience and the speakers.
The questions and answers could be presented in a PowerPoint format at the formal Q and A sessions. Questions texted to the
authors during their talks could be immediately answered or addressed in subsequent talks. Although difficult for some individuals
to embrace technology, confexting allows for interactivity and prompts discussion. Confexting is an effective method for interactivity
between the audience and speakers not previously utilized in a conference setting. The anonymity and asynchronous communication
enable conference participants to submit more questions than in the traditional setting. The speakers may be able to explain
more thoroughly difficult concepts more thoroughly with additional slides at Q and A sessions or may immediately answer texted
questions during their talks. 相似文献
54.
A. C. Chang L. C. Triarhou C. J. Alyea W. C. Low B. Ghetti 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1989,76(3):639-645
Summary Cerebellar cell suspensions were prepared from normal mouse embryos and implanted into the cerebellum of Purkinje cell degeneration (pcd) mutant mice, which are characterized by a virtually complete degeneration of Purkinje cells between postnatal day (P) 17 and P45. The expression of immunoreactivity for PEP-19, a developmentally-regulated brain-specific polypeptide, was analyzed in normal mouse cerebellum, as well as in pcd mutants with or without grafts. In the normal cerebellum, PEP-19 immunoreactivity was present in Purkinje cells. In unoperated mutants, 45 days of age or older, Purkinje cells were absent. In grafted pcd mice, numerous PEP-19 immunoreactive, neuroblast-like cells were seen in the graft at 5 days after transplantation. By 9 days, large PEP-19 immunoreactive neurons were found in the host molecular layer; by 17 days after transplantation, such neurons displayed an extensive dendritic tree and resembled differentiated Purkinje cells. The vast majority of PEP-19 immunoreactive cells was located in the molecular layer of the host at 9 days after transplantation and beyond; nonetheless, the same cells extended axonal processes toward the graft, indicating an affinity for co-grafted (possibly deep nuclei) neurons. These results point to the ability of donor Purkinje cells for survival, migration into the host brain and morphological and chemical differentiation following transplantation to the degenerated cerebellar cortex of the recipient mutants.On sabbatical leave from the Institute of Neurosciences, National Yang-Ming Medical College, Taipei, Taiwan 112, ROC 相似文献
55.
Corey Cutler Shuli Li Haesook T Kim Patricia Laglenne Kwok Chuen Szeto Laura Hoffmeister M Joel Harrison Vincent Ho Edwin Alyea Stephanie J Lee Robert Soiffer Stephen Sonis Joseph H Antin 《Biology of blood and marrow transplantation》2005,11(5):383-388
Oral mucositis occurs in up to 75% of recipients of high-dose chemoradiotherapy conditioning regimens used for allogeneic hematopoietic stem cell transplantation (HSCT). As a result of mucositis, narcotic analgesia and total parenteral nutrition (TPN) are commonly required after HSCT. Methotrexate, an antiproliferative graft-versus-host disease (GVHD) prophylaxis agent, impairs mucosal regeneration and worsens and prolongs mucositis. We assessed the effect of substituting sirolimus for methotrexate as GVHD prophylaxis on outcomes associated with mucositis. Two patient cohorts undergoing allogeneic HLA-matched related donor peripheral blood stem cell transplantation with cyclophosphamide/total body irradiation conditioning were prospectively analyzed for mucositis severity and retrospectively reviewed for correlative outcomes. GVHD prophylaxis consisted of sirolimus/tacrolimus (ST) in the study group and tacrolimus/methotrexate (TM) in the control group. Thirty patients received ST and 24 patients received TM as GVHD prophylaxis between October 2000 and May 2003. Mild, moderate, and severe mucositis was noted in 37%, 57%, and 7% of the ST group and 8%, 42%, and 50% of the TM group (P = .0002). Less TPN was used in the ST group than the TM group (17% versus 43% of posttransplantation hospital days; P = .02). The total number of narcotic days was lower in the ST group in comparison with the TM group (median, 13.5 versus 17 days; P = .08). The time to first hospital discharge was shorter in the ST group compared with the TM group (median, 18 versus 22 days; P = .07). The substitution of sirolimus for methotrexate as GVHD prophylaxis is associated with a reduction in mucositis severity. As a result, TPN and narcotic use are reduced, and hospitalization duration is shortened. Less toxic GVHD prophylaxis regimens without methotrexate may have a significant effect on patient quality of life, patient outcomes, and economic outcomes associated with allogeneic stem cell transplantation. 相似文献
56.
57.
Antonio C Lerario Antonio R Chacra Augusto Pimazoni-Netto Domingos Malerbi Jorge L Gross José EP Oliveira Marilia B Gomes Raul D Santos Reine MC Fonseca Roberto Betti Roberto Raduan 《Diabetology & metabolic syndrome》2010,2(1):35
The Brazilian Diabetes Society is starting an innovative project of quantitative assessment of medical arguments of and implementing a new way of elaborating SBD Position Statements. The final aim of this particular project is to propose a new Brazilian algorithm for the treatment of type 2 diabetes, based on the opinions of endocrinologists surveyed from a poll conducted on the Brazilian Diabetes Society website regarding the latest algorithm proposed by American Diabetes Association /European Association for the Study of Diabetes, published in January 2009.An additional source used, as a basis for the new algorithm, was to assess the acceptability of controversial arguments published in international literature, through a panel of renowned Brazilian specialists. Thirty controversial arguments in diabetes have been selected with their respective references, where each argument was assessed and scored according to its acceptability level and personal conviction of each member of the evaluation panel.This methodology was adapted using a similar approach to the one adopted in the recent position statement by the American College of Cardiology on coronary revascularization, of which not only cardiologists took part, but also specialists of other related areas. 相似文献
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60.
Jan H. Beumer Kouros Owzar Lionel D. Lewis Chen Jiang Julianne L. Holleran Susan M. Christner William Blum Steven Devine Jonathan E. Kolitz Charles Linker Ravi Vij Edwin P. Alyea Richard A. Larson Mark J. Ratain Merrill J. Egorin 《Cancer chemotherapy and pharmacology》2014,74(5):927-938