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51.
A. Simons Fritz Händel Langendorff Josef Frank F. Eillinger Happel Zwerg Fried Walter Schaefer Hedfeld E. Philipp Wehefritz Englmann 《Journal of cancer research and clinical oncology》1932,36(5-6):125-128
Ohne Zusammenfassung 相似文献
52.
E. Philipp H. J. Arndt I. Costero Erich Müller C. Kaufmann 《Journal of cancer research and clinical oncology》1931,34(5):174-177
Ohne Zusammenfassung 相似文献
53.
Wachsmuth Melchior W. V. Simon Oberniedermayr R. Hirschfeld Valentin Gerbis Ernst Philipp 《Journal of molecular medicine (Berlin, Germany)》1932,11(8):341-342
Ohne Zusammenfassung 相似文献
54.
Gabija Krutkyte Leyla Wenk Jonas Odermatt Philipp Schuetz Zeno Stanga Natalie Friedli 《Nutrients》2022,14(14)
Malnutrition is one of the most frequent metabolic challenges in the population of chronically ill patients. This results in increased administration of nutritional therapy in inpatient settings, which poses the risk of side effects, in particular, the development of refeeding syndrome. If not managed accordingly, it leads to a significant rise in morbidity and mortality. However, despite its importance, evidence-based recommendations on the management of refeeding syndrome are largely lacking, and only a few randomized controlled trials have been conducted. In light of this, the aim of this review is to raise awareness of refeeding syndrome in chronically ill patients by critically reviewing recent literature and providing a short overview as well as diagnosis and treatment algorithms of this underreported metabolic condition. In summary, recent findings suggest undergoing risk assessment and stratification for every patient receiving nutritional therapy. According to this, adaptation of energy and fluid support during the replenishment phase should be implemented in the nutritional therapy for patients at high risk. Additionally, continuous monitoring should take place, and appropriate actions should be initiated when necessary. 相似文献
55.
Yi Zhu Na Li Mingyang Huang Xi Chen Yu A. An Jianping Li Shangang Zhao Jan-Bernd Funcke Jianhong Cao Zhenyan He Qingzhang Zhu Zhuzhen Zhang Zhao V. Wang Lin Xu Kevin W. Williams Chien Li Kevin Grove Philipp E. Scherer 《药学学报(英文版)》2022,12(7):3063-3072
Adipose tissue is a promising target for treating obesity and metabolic diseases. However, pharmacological agents usually fail to effectively engage adipocytes due to their extraordinarily large size and insufficient vascularization, especially in obese subjects. We have previously shown that during cold exposure, connexin43 (Cx43) gap junctions are induced and activated to connect neighboring adipocytes to share limited sympathetic neuronal input amongst multiple cells. We reason the same mechanism may be leveraged to improve the efficacy of various pharmacological agents that target adipose tissue. Using an adipose tissue-specific Cx43 overexpression mouse model, we demonstrate effectiveness in connecting adipocytes to augment metabolic efficacy of the β3-adrenergic receptor agonist Mirabegron and FGF21. Additionally, combing those molecules with the Cx43 gap junction channel activator danegaptide shows a similar enhanced efficacy. In light of these findings, we propose a model in which connecting adipocytes via Cx43 gap junction channels primes adipose tissue to pharmacological agents designed to engage it. Thus, Cx43 gap junction activators hold great potential for combination with additional agents targeting adipose tissue. 相似文献
56.
Heather Fraser Winfrida TombeMdewa Ciaran KohliLynch Karen Hofman Stefano Tempia Meredith McMorrow Philipp Lambach Wayne Ramkrishna Cheryl Cohen Raymond Hutubessy Ijeoma Edoka 《Influenza and other respiratory viruses》2022,16(5):873
BackgroundInfluenza accounts for a substantial number of deaths and hospitalisations annually in South Africa. To address this disease burden, the South African National Department of Health introduced a trivalent inactivated influenza vaccination programme in 2010.MethodsWe adapted and populated the WHO Seasonal Influenza Immunization Costing Tool (WHO SIICT) with country‐specific data to estimate the cost of the influenza vaccination programme in South Africa. Data were obtained through key‐informant interviews at different levels of the health system and through a review of existing secondary data sources. Costs were estimated from a public provider perspective and expressed in 2018 prices. We conducted scenario analyses to assess the impact of different levels of programme expansion and the use of quadrivalent vaccines on total programme costs.ResultsTotal financial and economic costs were estimated at approximately USD 2.93 million and USD 7.91 million, respectively, while financial and economic cost per person immunised was estimated at USD 3.29 and USD 8.88, respectively. Expanding the programme by 5% and 10% increased economic cost per person immunised to USD 9.36 and USD 9.52 in the two scenarios, respectively. Finally, replacing trivalent inactivated influenza vaccine (TIV) with quadrivalent vaccine increased financial and economic costs to USD 4.89 and USD 10.48 per person immunised, respectively.ConclusionWe adapted the WHO SIICT and provide estimates of the total costs of the seasonal influenza vaccination programme in South Africa. These estimates provide a basis for planning future programme expansion and may serve as inputs for cost‐effectiveness analyses of seasonal influenza vaccination programmes. 相似文献
57.
58.
Aneurysms of the visceral arteries, especially of the pancreaticoduodenal artery, are rare. They show a wide clinical spectrum, ranging from asymptomatic incidental findings to rupture-inducing catastrophic bleedings. Since growth progression and the risk of rupture cannot be foreseen and there is no relation between the size of the aneurysm and propensity to rupture, rupture unfortunately carries a high mortality, >50%. Thus, all aneurysms of the pancreaticoduodenal artery should be treated. The therapy of choice, either operative intervention or catheter embolization, is determined by many factors. Among these are localization, size, relation to other vessels and neighboring organs, the urgency of intervention, and the experience of the therapist. Surgical therapy should be favored in patients with pancreaticoduodenal artery aneurysm due to celiac trunk occlusion. We report here our experience in the surgical treatment of pancreaticoduodenal artery aneurysms in association with celiac trunk occlusion or stenosis over the last 5 years. 相似文献
59.
Martin Allweyer Matthias Emde Ina Bhr Julia Spielmann Philipp Bieramperl Wiebke Naujoks Heike Kielstein 《Nutrients》2022,14(9)
Diet-induced obesity (DIO) mice models are commonly used to investigate obesity-related health problems. Until now, only sparse data exist on the influence of DIO on behavior and stress hormones in mice. The present study investigates high-fat DIO with two different feeding regimes on behavioral parameters in mice. Various behavioral tests (open field, elevated plus maze, social interaction, hotplate) were performed with female BALB/c and male C57BL/6 mice after a feeding period of twelve weeks (restrictive vs. ad libitum and normal-fat diet vs. high-fat diet) to investigate levels of anxiety and aggression. BALB/c mice were DIO-resistant and therefore the prerequisite for the behavior analyses was not attained. C57BL/6 mice fed a high-fat diet had a significantly higher body weight and fat mass compared to C57BL/6 mice fed a control diet. Interestingly, the DIO C57BL/6 mice showed no changes in their aggression- or anxiety-related behavior but showed a significant change in the anxiety index. This was probably due to a lower activity level, as other ethological parameters did not show an altered anxiety-related behavior. In the ad libitum-fed DIO group, the highest corticosterone level was detected. Changes due to the feeding regime (restrictive vs. ad libitum) were not observed. These results provide a possible hint to a bias in the investigation of DIO-related health problems in laboratory animal experiments, which may be influenced by the lower activity level. 相似文献
60.
The World Economic Forum recently released a Global Health Data Charter. The objective of this qualitative case study was to determine if the Charter's eight principles, along with a set of data management practice standards, could be used as an assessment tool to determine the maturity of data management practices within a health organization. The Health Authority — Abu Dhabi (HAAD) — represented the bounded holistic case for this study. The data collection methods included structured interviews, completion of an assessment tool, and electronic documentation review. The findings demonstrated good to excellent compliance between HAAD's data management practices and the Charter principles, indicating a high level of data management maturity. Applying the Charter as the assessment framework proved to be successful. This framework provided a simple yet comprehensive approach to rapidly determine HAAD's level of health data management maturity. This assessment tool may prove to be useful for other health organizations. 相似文献