全文获取类型
收费全文 | 32404篇 |
免费 | 3001篇 |
国内免费 | 39篇 |
专业分类
耳鼻咽喉 | 315篇 |
儿科学 | 958篇 |
妇产科学 | 805篇 |
基础医学 | 3966篇 |
口腔科学 | 516篇 |
临床医学 | 3603篇 |
内科学 | 6631篇 |
皮肤病学 | 535篇 |
神经病学 | 3008篇 |
特种医学 | 1032篇 |
外国民族医学 | 3篇 |
外科学 | 4510篇 |
综合类 | 653篇 |
一般理论 | 49篇 |
预防医学 | 3829篇 |
眼科学 | 527篇 |
药学 | 1992篇 |
中国医学 | 34篇 |
肿瘤学 | 2478篇 |
出版年
2023年 | 219篇 |
2022年 | 333篇 |
2021年 | 786篇 |
2020年 | 441篇 |
2019年 | 768篇 |
2018年 | 866篇 |
2017年 | 614篇 |
2016年 | 613篇 |
2015年 | 699篇 |
2014年 | 960篇 |
2013年 | 1366篇 |
2012年 | 1933篇 |
2011年 | 1923篇 |
2010年 | 1098篇 |
2009年 | 1000篇 |
2008年 | 1635篇 |
2007年 | 1714篇 |
2006年 | 1662篇 |
2005年 | 1635篇 |
2004年 | 1490篇 |
2003年 | 1380篇 |
2002年 | 1201篇 |
2001年 | 720篇 |
2000年 | 729篇 |
1999年 | 675篇 |
1998年 | 367篇 |
1997年 | 269篇 |
1996年 | 279篇 |
1995年 | 268篇 |
1994年 | 224篇 |
1993年 | 215篇 |
1992年 | 489篇 |
1991年 | 473篇 |
1990年 | 429篇 |
1989年 | 438篇 |
1988年 | 382篇 |
1987年 | 369篇 |
1986年 | 338篇 |
1985年 | 348篇 |
1984年 | 285篇 |
1983年 | 255篇 |
1982年 | 190篇 |
1979年 | 265篇 |
1978年 | 197篇 |
1977年 | 173篇 |
1974年 | 185篇 |
1973年 | 228篇 |
1972年 | 210篇 |
1971年 | 172篇 |
1969年 | 171篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
81.
To thin or not to thin: the use of the anterolateral thigh flap in the reconstruction of intraoral defects. 总被引:4,自引:0,他引:4
G L Ross R Dunn J Kirkpatrick C E Koshy L W Alkureishi N Bennett D S Soutar I G Camilleri 《British journal of plastic surgery》2003,56(4):409-413
The anterolateral thigh (ALT) flap has achieved popularity recently for free-flap reconstruction of intraoral defects following excision of squamous cell carcinoma. We have assessed the feasibility of the ALT flap as a free flap for oral lining and the potential use of the thinned ALT flap in a one-stage reconstruction. We used the ALT flap to reconstruct the oral cavity in 18 consecutive patients between December 2000 and December 2001 following intraoral resection of squamous cell carcinoma. Twelve patients underwent reconstruction using a standard ALT flap, four patients received a thinned ALT flap in a one-stage procedure, one patient received a standard ALT flap in combination with a fibula flap and one patient received a combination of a standard ALT flap and vascularised iliac bone. There were no complications in any of the 14 cases in which a standard ALT flap was used. Two of these flaps were thinned subsequently as secondary procedures. Of the four thinned ALT flaps, one flap failed completely and two flaps experienced partial necrosis. In all but one case the donor site was closed directly with minimal donor-site morbidity. The ALT flap is a versatile flap that can be used in combination with other flaps for more complex defects with minimal donor-site morbidity and is a useful alternative in the armamentarium of the head and neck surgeon. Thinning of the flap is best performed as a secondary procedure, should it be required. 相似文献
82.
83.
Susan D. Ross M.D. Angela DiGeorge B.S. Janet E. Connelly B.S. Gregory W. Whiting B.S Neil McDonnell Pharm.D. 《Pharmacotherapy》1998,18(6):1290-1297
We performed a literature search for all clinical studies reporting outcomes in patients with the acquired immunodeficiency syndrome (AIDS) receiving granulocyte-macrophage colony-stimulating factor (GM-CSF) for any indication. Safety outcomes included human immunodeficiency virus replication, immune status, and frequency of opportunistic infections and neoplasms. Data were synthesized qualitatively. We identified 22 studies (274 patients): 12 addressed AIDS neutropenia, 8 AIDS cancer therapy, and 2 opportunistic infections. Viral burden was assessed by serum p24Ag in 15 studies. Nine reported no change in levels, three net decreases, and three net increases. All studies showing net increases involved patients receiving GM-CSF without a concurrent antiretroviral. The CD4 counts were unchanged in 5 studies, increased in 3, and not reported in 14. The incidence of neoplasms or new opportunistic infections was low. The literature suggests no increased risk of viral replication or clinical deterioration in patients with AIDS who take GM-CSF concurrently with zidovudine. 相似文献
84.
Bruce Becker MD Robert Woolard MD Ted D. Nirenberg PhD P. Allison Minugh PhD Richard Longabaugh EdD Patrick R. Clifford PhD 《Academic emergency medicine》1995,2(9):784-790
Objectives: To determine the incidence of alcohol use in subcritically injured patients presenting to the ED, by using a saliva alcohol test (SAT) at ED triage during the ED initial assessment; to compare the incidence of alcohol use revealed by the SAT with documentation of alcohol use by ED nurses and emergency physicians (EPs) blinded to the SAT results; and to describe the demographics of the SAT-positive, subcritically injured population.
Methods: A blinded, prospective, observational evaluation of ED patients presenting with subcritical injuries was performed. The patients were tested for alcohol use with an SAT, and a subsequent record review was conducted for extraction of demographic data and evidence of documentation of alcohol use by ED nurses and EPs blinded to the SAT results.
Results: During the study. 791 subcritically injured patients had SATs performed. Twenty-one percent of these patients were found to be alcohol-positive by SAT. Either the ED nurse or the EP documented a clinical impression of alcohol use for 52% of the SAT-positive patients. There were higher SAT-positive rates among men (24%), victims of assault (47%), and patients arriving at night (41%).
Conclusions: While the SAT identified 21% of the subcritically injured patient population as alcohol-positive, ED nurse and EP documentation did not identify half of these alcohol-positive patients. Many of these patients may be at risk for additional injuries related to their drinking behavior. 相似文献
Methods: A blinded, prospective, observational evaluation of ED patients presenting with subcritical injuries was performed. The patients were tested for alcohol use with an SAT, and a subsequent record review was conducted for extraction of demographic data and evidence of documentation of alcohol use by ED nurses and EPs blinded to the SAT results.
Results: During the study. 791 subcritically injured patients had SATs performed. Twenty-one percent of these patients were found to be alcohol-positive by SAT. Either the ED nurse or the EP documented a clinical impression of alcohol use for 52% of the SAT-positive patients. There were higher SAT-positive rates among men (24%), victims of assault (47%), and patients arriving at night (41%).
Conclusions: While the SAT identified 21% of the subcritically injured patient population as alcohol-positive, ED nurse and EP documentation did not identify half of these alcohol-positive patients. Many of these patients may be at risk for additional injuries related to their drinking behavior. 相似文献
85.
Efficacy of Bupivacaine Delivered by Wound Catheter for Post-Caesarean Section Analgesia 总被引:4,自引:0,他引:4
David W. J. Mecklem FANZCA Michael D. Humphrey FRACOG FRCOG Ross W. Hicks DipRACOG 《The Australian & New Zealand journal of obstetrics & gynaecology》1995,35(4):416-421
Summary: A prospective, randomized, double-blind trial was conducted to assess contribution to postoperative analgesia of intermittent instillation of 0.25% bupivacaine beneath the rectus sheath in 70 women delivered by lower uterine segment Caesarean section. The operations were performed via a Pfannenstiel incision under spinal anaesthesia. Background intravenous narcotic analgesia was provided with a patient controlled analgesia system (PCAS) using a standard morphine regimen.
Overall (44 hr) mean morphine consumption was significantly greater in the placebo (saline) group compared to the treatment group (84.2 mg versus 63.3 mg. Two tailed t test p<0.001). The most significant intergroup differences in narcotic use were found in the first 4 hours and between 24 and 36 hours after commencing PCAS (Two tailed t test p=0.014 and 0.003 respectively).
Subjective pain scores were assessed with a 10 cm visual analogue scale (VAS). The mean peak VAS score was greater in controls (5.37) than the treatment group (4.25) between 18 and 24 hours postoperatively (Mann-Whitney U=424, p=0.027). There were no intergroup differences in pain scores for any other time period. The overall incidence of nausea was lower in the treatment group compared to the control group (Chi squared with Yates' correction p=0.046) and a lower degree of sedation was seen in those receiving bupivacaine between 4 and 8 hours after commencing PCAS (Mann-Whitney U=427, p=0.028). No differences in other narcotic related side-effects (vomiting and pruritus) were shown between groups.
Regular instillation of 0.25% bupivacaine beneath the rectus sheath of women delivered by Caesarean section reduces their morphine requirements by 25% in the 44 hours after operation, with an associated reduction in both nausea and early sedation. 相似文献
Overall (44 hr) mean morphine consumption was significantly greater in the placebo (saline) group compared to the treatment group (84.2 mg versus 63.3 mg. Two tailed t test p<0.001). The most significant intergroup differences in narcotic use were found in the first 4 hours and between 24 and 36 hours after commencing PCAS (Two tailed t test p=0.014 and 0.003 respectively).
Subjective pain scores were assessed with a 10 cm visual analogue scale (VAS). The mean peak VAS score was greater in controls (5.37) than the treatment group (4.25) between 18 and 24 hours postoperatively (Mann-Whitney U=424, p=0.027). There were no intergroup differences in pain scores for any other time period. The overall incidence of nausea was lower in the treatment group compared to the control group (Chi squared with Yates' correction p=0.046) and a lower degree of sedation was seen in those receiving bupivacaine between 4 and 8 hours after commencing PCAS (Mann-Whitney U=427, p=0.028). No differences in other narcotic related side-effects (vomiting and pruritus) were shown between groups.
Regular instillation of 0.25% bupivacaine beneath the rectus sheath of women delivered by Caesarean section reduces their morphine requirements by 25% in the 44 hours after operation, with an associated reduction in both nausea and early sedation. 相似文献
86.
D J Baumgardner D K Johnson J E Ross 《The Journal of the American Board of Family Practice / American Board of Family Practice》1988,1(1):24-28
A serological investigation has suggested that Legionella pneumophila may be associated with sore throat in adults. In a study of 177 adults and children with acute pharyngitis, Legionella species were not isolated from pharyngeal cultures, which utilized selective and nonselective buffered charcoal-yeast extract media. Group A beta-hemolytic streptococci were isolated from 14 percent of the 177 symptomatic patients. Throat cultures from 88 asymptomatic control subjects were negative for Legionella and beta-hemolytic streptococci. Further studies are needed to determine if Legionella species are associated with acute pharyngitis. 相似文献
87.
88.
89.
Experimental studies demonstrated a severe cardiac load of the CO2 pneumoperitoneum caused by an accelerated after- and a decreased preload. Patients displaying cardiovascular risks are therefore
often rejected from laparoscopic surgery. Hence, the pathophysiological changes and the intraoperative risk of the CO2 pneumoperitoneum in high-risk cardiopulmonary patients (NYHA II–III, n= 15) undergoing laparoscopic cholecystectomy are described. The changes in cardiac after- and preload seem to be due to the
elevated intraabdominal pressure rather than transperitoneally resorbed CO2 and are reversible by desufflation. In one patient conversion to open operation had to be performed because of a severe drop
in cardiac output and right ventricle ejection fraction. Mixed oxygen saturation was predicting intraoperative worsening in
this case. The described pathophysiological changes may seem to be well tolerated even in high-risk cardiac patients. Monitoring
of hemodynamics should include an arterial catheter line and blood gas analyses. Pharmacologic interventions or pressureless
laparoscopic procedures might not be necessary as long as laparoscopic cholecystectomy is performed.
Received: 13 December 1996/Accepted: 8 January 1997 相似文献
90.
Tim Elliott Marc Bonneville Juan Carlos Zúiga-Pflücker Paul R. Walker David Essayan Nicolas Glaichenhaus Anna Vyakarnam Jean-Laurent Casanova Yang Liu Hugh Auchincloss Jr Gerry Waneck Christian LeGuern Cezmi Akdis Allison Green 《Current opinion in immunology》2002,14(6):673
A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in immunology. 相似文献