全文获取类型
收费全文 | 4271篇 |
免费 | 332篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 68篇 |
儿科学 | 136篇 |
妇产科学 | 83篇 |
基础医学 | 616篇 |
口腔科学 | 57篇 |
临床医学 | 494篇 |
内科学 | 795篇 |
皮肤病学 | 76篇 |
神经病学 | 556篇 |
特种医学 | 167篇 |
外科学 | 579篇 |
综合类 | 13篇 |
预防医学 | 475篇 |
眼科学 | 29篇 |
药学 | 253篇 |
中国医学 | 12篇 |
肿瘤学 | 206篇 |
出版年
2024年 | 7篇 |
2023年 | 79篇 |
2022年 | 99篇 |
2021年 | 223篇 |
2020年 | 129篇 |
2019年 | 164篇 |
2018年 | 236篇 |
2017年 | 161篇 |
2016年 | 164篇 |
2015年 | 179篇 |
2014年 | 228篇 |
2013年 | 260篇 |
2012年 | 410篇 |
2011年 | 376篇 |
2010年 | 179篇 |
2009年 | 167篇 |
2008年 | 255篇 |
2007年 | 214篇 |
2006年 | 231篇 |
2005年 | 207篇 |
2004年 | 145篇 |
2003年 | 141篇 |
2002年 | 103篇 |
2001年 | 14篇 |
2000年 | 13篇 |
1999年 | 20篇 |
1998年 | 9篇 |
1997年 | 7篇 |
1996年 | 17篇 |
1995年 | 9篇 |
1994年 | 9篇 |
1993年 | 8篇 |
1992年 | 4篇 |
1985年 | 4篇 |
1983年 | 4篇 |
1981年 | 4篇 |
1976年 | 4篇 |
1942年 | 5篇 |
1939年 | 3篇 |
1932年 | 3篇 |
1928年 | 5篇 |
1926年 | 7篇 |
1923年 | 8篇 |
1922年 | 6篇 |
1921年 | 5篇 |
1913年 | 3篇 |
1912年 | 6篇 |
1911年 | 7篇 |
1910年 | 3篇 |
1874年 | 3篇 |
排序方式: 共有4615条查询结果,搜索用时 0 毫秒
51.
Maggie D. Clarke Alexis N. Bosseler Julia C. Mizrahi Erica R. Peterson Eric Larson Andrew N. Meltzoff Patricia K. Kuhl Samu Taulu 《Human brain mapping》2022,43(12):3609
The excellent temporal resolution and advanced spatial resolution of magnetoencephalography (MEG) makes it an excellent tool to study the neural dynamics underlying cognitive processes in the developing brain. Nonetheless, a number of challenges exist when using MEG to image infant populations. There is a persistent belief that collecting MEG data with infants presents a number of limitations and challenges that are difficult to overcome. Due to this notion, many researchers either avoid conducting infant MEG research or believe that, in order to collect high‐quality data, they must impose limiting restrictions on the infant or the experimental paradigm. In this article, we discuss the various challenges unique to imaging awake infants and young children with MEG, and share general best‐practice guidelines and recommendations for data collection, acquisition, preprocessing, and analysis. The current article is focused on methodology that allows investigators to test the sensory, perceptual, and cognitive capacities of awake and moving infants. We believe that such methodology opens the pathway for using MEG to provide mechanistic explanations for the complex behavior observed in awake, sentient, and dynamically interacting infants, thus addressing core topics in developmental cognitive neuroscience. 相似文献
52.
Pablo Canales-Herrerias Etienne Crickx Matteo Broketa Aurlien Sokal Guilhem Chenon Imane Azzaoui Alexis Vandenberghe Angga Perima Bruno Iannascoli Odile Richard-Le Goff Carlos Castrillon Guillaume Mottet Delphine Sterlin Ailsa Robbins Marc Michel Patrick England Gael A. Millot Klaus Eyer Jean Baudry Matthieu Mahevas Pierre Bruhns 《The Journal of clinical investigation》2022,132(12)
The major therapeutic goal for immune thrombocytopenic purpura (ITP) is to restore normal platelet counts using drugs to promote platelet production or by interfering with mechanisms responsible for platelet destruction. Eighty percent of patients with ITP possess anti–integrin αIIbβ3 IgG autoantibodies that cause platelet opsonization and phagocytosis. The spleen is considered the primary site of autoantibody production by autoreactive B cells and platelet destruction. The immediate failure in approximately 50% of patients to recover a normal platelet count after anti-CD20 rituximab-mediated B cell depletion and splenectomy suggests that autoreactive, rituximab-resistant, IgG-secreting B cells (IgG-SCs) reside in other anatomical compartments. We analyzed more than 3,300 single IgG-SCs from spleen, bone marrow, and/or blood of 27 patients with ITP, revealing high interindividual variability in affinity for αIIbβ3, with variations over 3 logs. IgG-SC dissemination and range of affinities were, however, similar for each patient. Longitudinal analysis of autoreactive IgG-SCs upon treatment with the anti-CD38 mAb daratumumab demonstrated variable outcomes, from complete remission to failure with persistence of high-affinity anti–αIIbβ3 IgG-SCs in the bone marrow. This study demonstrates the existence and dissemination of high-affinity autoreactive plasma cells in multiple anatomical compartments of patients with ITP that may cause the failure of current therapies. 相似文献
53.
Zhong Ning Leonard Goh Roland Yii Lin Teo Bui Khiong Chung Alexis Ching Wong Chen-June Seak 《Medicine》2022,101(31)
Heart failure leading to cardiac ascites is an extremely rare and underrecognized entity in clinical practice. Recognizing cardiac ascites can be difficult, especially since patients presenting with ascites may have more than 1 etiology. Various biomarkers are available to aid in the diagnosis of cardiac ascites, though with differing sensitivities and specificities. Such biomarkers include serum albumin, ascitic albumin and protein, as well as serum N-terminal pro-brain natriuretic peptide (NT-proBNP). While serum NT-proBNP is a powerful biomarker in distinguishing the etiology of ascites and monitoring treatment progression, its cost can be prohibitive in low-resource settings. Clinicians practicing under these circumstances may opt to rely on other parameters to manage their patients. We go on further to report a series of 3 patients with cardiac ascites to illustrate how these biomarkers may be employed in the management of this patient population. Clinicians should always keep in mind the differential diagnosis of cardiac failure as a cause of ascites. The resolution of cardiac ascites may serve as a surrogate clinical marker for response to antifailure therapy in lieu of NT-proBNP at resource-scarce centers. 相似文献
54.
55.
Hisham F. Bahmad Robert Poppiti John Alexis 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2021,15(2):487-491
Background and aimsDiabetes mellitus (DM) is a chronic metabolic disease associated with long-term multisystem complications, among which nonhealing diabetic foot ulcers (DFUs) are recognized as major cause of morbidity and mortality. Treating DFUs with surgical procedures such as synthetic or biological skin grafts or skin substitutes has several limitations, where none of the currently available skin substitutes is ideal.MethodsOVID/Medline and PubMed databases were searched using the Medical Subject Heading (MeSH) or Title/Abstract words (“diabetic foot ulcers”, “skin substitutes”, and “nanofibers”), to identify published research studies on DFUs and nanofibers.ResultsElectrospinning nanotechnology is being used in the biomedical field to produce polymeric nanofibers impregnated with drugs for wound healing, burns and diabetic ulcers. Those nanofibers also enable seeding of cells into them and culturing them in vitro to synthesize tissue-like structures. Knowing the advantages of generating patient-specific induced pluripotent stem cells (iPSCs) and organoids in three-dimension (3D), including skin organoids, it is worth mingling these technologies to develop tissue-engineered biological skin substitutes.ConclusionNanofiber-skin substitutes hold promise for treatment of patients suffering from DFUs and inspire novel strategies that could be applied to other organ systems as well, introducing a new era of “regenerative and personalized medicine”. 相似文献
56.
57.
58.
59.
60.