全文获取类型
收费全文 | 2406篇 |
免费 | 159篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 41篇 |
妇产科学 | 34篇 |
基础医学 | 266篇 |
口腔科学 | 50篇 |
临床医学 | 166篇 |
内科学 | 590篇 |
皮肤病学 | 25篇 |
神经病学 | 240篇 |
特种医学 | 121篇 |
外科学 | 315篇 |
综合类 | 3篇 |
预防医学 | 234篇 |
眼科学 | 52篇 |
药学 | 167篇 |
中国医学 | 8篇 |
肿瘤学 | 264篇 |
出版年
2024年 | 5篇 |
2023年 | 39篇 |
2022年 | 76篇 |
2021年 | 172篇 |
2020年 | 87篇 |
2019年 | 112篇 |
2018年 | 106篇 |
2017年 | 89篇 |
2016年 | 88篇 |
2015年 | 119篇 |
2014年 | 109篇 |
2013年 | 139篇 |
2012年 | 193篇 |
2011年 | 175篇 |
2010年 | 105篇 |
2009年 | 100篇 |
2008年 | 128篇 |
2007年 | 135篇 |
2006年 | 117篇 |
2005年 | 88篇 |
2004年 | 100篇 |
2003年 | 60篇 |
2002年 | 54篇 |
2001年 | 17篇 |
2000年 | 19篇 |
1999年 | 18篇 |
1998年 | 16篇 |
1997年 | 3篇 |
1996年 | 9篇 |
1995年 | 6篇 |
1994年 | 2篇 |
1993年 | 8篇 |
1992年 | 17篇 |
1991年 | 8篇 |
1990年 | 6篇 |
1989年 | 9篇 |
1988年 | 7篇 |
1987年 | 3篇 |
1986年 | 3篇 |
1985年 | 6篇 |
1984年 | 2篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1974年 | 1篇 |
1973年 | 3篇 |
1972年 | 4篇 |
1971年 | 3篇 |
1970年 | 1篇 |
1969年 | 4篇 |
1968年 | 4篇 |
排序方式: 共有2583条查询结果,搜索用时 31 毫秒
41.
Alessio Gasperetti MD Marco Schiavone MD Mauro Biffi MD Michela Casella MD PhD Paolo Compagnucci MD Gianfranco Mitacchione MD PhD Andrea Angeletti MD Julia Vogler MD Riccardo Proietti MD PhD Matteo Ziacchi MD Antonio Dello Russo MD PhD Andrea Natale MD Roland R. Tilz MD Giovanni B. Forleo MD PhD 《Journal of cardiovascular electrophysiology》2021,32(11):3035-3041
42.
R Perondi L Gregorini G Pomidossi A Saino P Alessio A Zanchetti G Mancia 《European heart journal》1991,12(3):363-367
Although intravenous digital subtraction ventriculography (IDSV) is increasingly used to estimate end-diastolic left ventricular volume (EDV), end-systolic left ventricular volume (ESV) and left ventricular ejection fraction (EF), its ability to reproduce the precise estimates provided by left ventricle cineangiography (LVCA) and its role in clinical cardiology have not been unequivocally established. In 32 patients subjected to cardiac catheterization for a variety of cardiac disorders and a normal or reduced left ventricular function the EDV, ESV and EF provided by a 30 degrees right anterior oblique LVCA were compared with those provided by a 30 degrees right anterior oblique IDSV. The mean EDV, ESV and EF obtained by IDSV in the 32 patients were superimposable on those obtained by LVCA. The individual EDV, ESV and EF values provided by the two methods were all related in a close linear fashion. For EF the correlation coefficient was 0.98 and the 90% confidence interval of the mean difference between the two series of values was +/- 6.1%, i.e. +/- 10% error compared to the mean EF provided by LVCA. Thus IDSV is a reliable and not too invasive method for estimating left ventricle volumes and ejection fraction. It might provide serial estimations with a better assessment of the evolution of a patient's disease and the effect of treatment. 相似文献
43.
Ballestrero A Boy D Gonella R Miglino M Clavio M Barbero V Nencioni A Gobbi M Patrone F 《Annals of hematology》2008,87(1):49-55
To evaluate the safety and efficacy of pegfilgrastim administered as haematological support after autologous peripheral blood
stem cell transplantation, we compared 44 patients with solid tumours and lymphomas receiving a 6-mg single dose of pegfilgrastim
on day +5 after transplantation to a historical control group of 25 patients receiving filgrastim 5 μg kg−1 day−1 starting on day +5. There were no significant differences in haematological recovery nor in the incidence and duration of
neutropenic fever. Median duration of grade 4 neutropenia in the pegfilgrastim and filgrastim group was similar. The incidence
of grade III–IV mucositis was lower in pegfilgrastim than in filgrastim group due to the significant difference observed among
the patients with solid tumours (p = 0.00). The only adverse event considered to be cytokine related was mild to moderate bone pain occurring during haematological
recovery. According to the present study design and taking into account the current prices in our institution, the cost of
the two drugs was similar in both treatment groups. In conclusion, a single injection of pegfilgrastim administered at day
+5 post-transplantation shows comparable safety and efficacy profiles to daily injections of filgrastim and may be cost effective.
Alberto Ballestrero and Davide Boy contributed equally to this article. 相似文献
44.
Cancer procoagulant in acute lymphoblastic leukemia 总被引:1,自引:0,他引:1
M G Alessio A Falanga R Consonni R Bassan B Minetti M B Donati T Barbui 《European journal of haematology》1990,45(2):78-81
In a previous study we characterized cancer procoagulant (CP), a 68 kd cysteine proteinase which directly activates coagulation factor X in various subtypes (from M1 to M5) of acute non-lymphoblastic leukemia (ANLL). The aim of this study was to determine whether CP is also expressed by acute lymphoblastic leukemia (ALL) cells. Blasts from 25 ALL patients were extracted and tested for their procoagulant properties. 16 samples (64%) shortened the recalcification time of normal human plasma, and 9 (36%) did not. 8 of the 16 active samples showed properties compatible with CP, i.e. independence from factor VII in triggering blood coagulation and sensitivity to cysteine proteinase inhibitors. Selected samples also cross-reacted with a polyclonal antibody raised against purified CP. The specific activity of CP in ALL extracts was significantly lower than in most ANLL types previously studied (all but M4). These finding indicate that CP can be a property of the lymphoid phenotype although its expression may be lower than in the myeloid phenotype. 相似文献
45.
Maarten A.J. De Smet Alessio Lissoni Timur Nezlobinsky Nan Wang Eef Dries Marta Prez-Hernndez Xianming Lin Matthew Amoni Tim Vervliet Katja Witschas Eli Rothenberg Geert Bultynck Rainer Schulz Alexander V. Panfilov Mario Delmar Karin R. Sipido Luc Leybaert 《The Journal of clinical investigation》2021,131(7)
Cx43, a major cardiac connexin, forms precursor hemichannels that accrue at the intercalated disc to assemble as gap junctions. While gap junctions are crucial for electrical conduction in the heart, little is known about the potential roles of hemichannels. Recent evidence suggests that inhibiting Cx43 hemichannel opening with Gap19 has antiarrhythmic effects. Here, we used multiple electrophysiology, imaging, and super-resolution techniques to understand and define the conditions underlying Cx43 hemichannel activation in ventricular cardiomyocytes, their contribution to diastolic Ca2+ release from the sarcoplasmic reticulum, and their impact on electrical stability. We showed that Cx43 hemichannels were activated during diastolic Ca2+ release in single ventricular cardiomyocytes and cardiomyocyte cell pairs from mice and pigs. This activation involved Cx43 hemichannel Ca2+ entry and coupling to Ca2+ release microdomains at the intercalated disc, resulting in enhanced Ca2+ dynamics. Hemichannel opening furthermore contributed to delayed afterdepolarizations and triggered action potentials. In single cardiomyocytes, cardiomyocyte cell pairs, and arterially perfused tissue wedges from failing human hearts, increased hemichannel activity contributed to electrical instability compared with nonfailing rejected donor hearts. We conclude that microdomain coupling between Cx43 hemichannels and Ca2+ release is a potentially novel, targetable mechanism of cardiac arrhythmogenesis in heart failure. 相似文献
46.
Cristina Costa Antonio Curtoni Francesca Sidoti Cinzia Balloco Salvatore Simeone Samantha Mantovani Elsa Piasentin Alessio Daniela Libertucci Luisa Delsedime Paolo Solidoro Sergio Baldi Rossana Cavallo 《Archives of virology》2013,158(7):1461-1465
The role of human cytomegalovirus (HCMV) in lung transplantation (LT) and drawbacks related to viral quantification in bronchoalveolar lavage (BAL) underline the potential usefulness of investigating other specimens. Thirty-three LT recipients were prospectively studied by HCMV quantitative real time PCR on matched transbronchial biopsy (TBB), BAL, and whole blood specimens. Overall, 27/33 patients turned out HCMV-positive in at least one specimen: 7.1 %, 37.1 %, and 13.5 % of TBB, BAL, and blood samples, respectively. No significant association between HCMV on all types of specimens and acute rejection, lymphocytic bronchiolitis, bronchiolitis obliterans and bronchiolitis obliterans syndrome was found. HCMV pneumonia was associated to HCMV detection on TBB (p = 0.003) and whole blood (p = 0.008), not on BAL (p = 0.47). The highest mean viral load was detected in TBB from cases with HCMV pneumonia in comparison to all other cases, suggesting the potential use of HCMV investigation in TBB for evaluating posttransplant complications. 相似文献
47.
Rigoli Mattia Facchin Alessio Cardile Davide Beschin Nicoletta Luzzatti Claudio 《Neurological sciences》2021,42(6):2461-2469
Neurological Sciences - The speed of information processing is one of the most reliable indices of cognitive efficiency. The most common way to evaluate this ability is to assess reaction times... 相似文献
48.
Strazzulla Alessio Postorino Maria Concetta Youbong Tracie Rouyer Maxence Flateau Clara Chakvetadze Catherine de Pontfarcy Astrid Pitsch Aurelia Jochmans Sebastien Belfeki Nabil Monchi Mehran Diamantis Sylvain 《European journal of clinical microbiology & infectious diseases》2021,40(7):1511-1516
European Journal of Clinical Microbiology & Infectious Diseases - This is a subanalysis of a previous study which compared the effectiveness of trimetoprim-sulfametoxazole (TMP-SMX) with all... 相似文献
49.
Alessio Cittadini Federica Marsigli Andrea Sica Domenico P Santonastaso Emanuele Russo Emiliano Gamberini Vanni Agnoletti 《Indian Journal of Critical Care Medicine》2021,25(3):351
How to cite this article: Cittadini A, Marsigli F, Sica A, Santonastaso DP, Russo E, Gamberini E, et al. Video Laryngoscopy-guided Nasal Intubation: One More Bullet in Our Rifle. Indian J Crit Care Med 2021;25(3):351. 相似文献
50.
Patrick Maschmeyer Gitta Anne Heinz Christopher Mark Skopnik Lisanne Lutter Alessio Mazzoni Frederik Heinrich Sae Lim von Stuckrad Lorenz Elias Wirth Cam Loan Tran René Riedel Katrin Lehmann Imme Sakwa Rolando Cimaz Francesco Giudici Marcus Alexander Mall Philipp Enghard Bas Vastert Hyun-Dong Chang Pawel Durek Francesco Annunziato Femke van Wijk Andreas Radbruch Tilmann Kallinich Mir-Farzin Mashreghi 《European journal of immunology》2021,51(4):915-929