全文获取类型
收费全文 | 20986篇 |
免费 | 1141篇 |
国内免费 | 176篇 |
专业分类
耳鼻咽喉 | 266篇 |
儿科学 | 418篇 |
妇产科学 | 468篇 |
基础医学 | 2387篇 |
口腔科学 | 753篇 |
临床医学 | 1672篇 |
内科学 | 5256篇 |
皮肤病学 | 248篇 |
神经病学 | 2386篇 |
特种医学 | 767篇 |
外科学 | 3599篇 |
综合类 | 48篇 |
一般理论 | 5篇 |
预防医学 | 843篇 |
眼科学 | 323篇 |
药学 | 1175篇 |
中国医学 | 29篇 |
肿瘤学 | 1660篇 |
出版年
2024年 | 18篇 |
2023年 | 215篇 |
2022年 | 498篇 |
2021年 | 797篇 |
2020年 | 467篇 |
2019年 | 658篇 |
2018年 | 719篇 |
2017年 | 546篇 |
2016年 | 609篇 |
2015年 | 658篇 |
2014年 | 889篇 |
2013年 | 1227篇 |
2012年 | 1682篇 |
2011年 | 1781篇 |
2010年 | 930篇 |
2009年 | 900篇 |
2008年 | 1314篇 |
2007年 | 1284篇 |
2006年 | 1125篇 |
2005年 | 1104篇 |
2004年 | 1064篇 |
2003年 | 827篇 |
2002年 | 815篇 |
2001年 | 204篇 |
2000年 | 171篇 |
1999年 | 178篇 |
1998年 | 162篇 |
1997年 | 136篇 |
1996年 | 109篇 |
1995年 | 99篇 |
1994年 | 88篇 |
1993年 | 61篇 |
1992年 | 101篇 |
1991年 | 89篇 |
1990年 | 87篇 |
1989年 | 82篇 |
1988年 | 55篇 |
1987年 | 62篇 |
1986年 | 57篇 |
1985年 | 35篇 |
1984年 | 46篇 |
1983年 | 48篇 |
1982年 | 36篇 |
1981年 | 28篇 |
1980年 | 25篇 |
1979年 | 27篇 |
1978年 | 14篇 |
1973年 | 23篇 |
1970年 | 15篇 |
1969年 | 14篇 |
排序方式: 共有10000条查询结果,搜索用时 296 毫秒
61.
62.
Craig B. Morgenthal Matthew D. Shane Alessandro Stival Nana Gletsu Graham Milam Vickie Swafford John G. Hunter C. Daniel Smith 《Journal of gastrointestinal surgery》2007,11(6):693-700
Laparoscopic Nissen fundoplication (LNF) has become the most commonly performed antireflux procedure since its introduction
in 1991. There are few studies with greater than 5-year outcomes. Herein we report a series of 312 consecutive patients who
underwent primary LNF before 1996. Follow-up of more than 6 years was available in 166 patients, and the mean follow-up was
11 years (median 11.1 years, range 6.1–13.3 years). Prospective data collection included preoperative and current symptom
scores (scale 0 = none to 3 = severe), as well as the level of patient satisfaction and use of antireflux medications. Total
symptom score for each patient was summed from seven symptoms for a maximum value of 21. Heartburn and regurgitation were
the most improved symptoms; however, all symptoms were significantly improved (P < 0.01). The total symptom score at follow-up was 2.6 down from 7.5 at baseline, with a mean difference of −4.9 (range −12
to 3). The percentage of patients stating they would have the procedure again was 93.3%, and 70% were off daily antireflux
medications. Outcomes at a mean of 11 years after LNF are excellent, and the majority of patients had their symptoms resolved
or significantly improved and are satisfied with their results.
Presented at the 47th Annual Meeting of the Society for Surgery of the Alimentary Tract, May 22, 2006, Los Angeles, CA 相似文献
63.
Christian Casali Alessandro Stefani Pamela Natali Giulio Rossi Uliano Morandi 《European journal of cardio-thoracic surgery》2005,28(1):33-38
OBJECTIVE: Patients with non-small cell lung cancer (NSCLC) with metastases to ipsilateral mediastinal lymph nodes (N2) are an heterogeneous group of patients as regard to prognosis and treatment. Indication and timing of surgery remain controversial. The present study investigates the prognostic factors, in order to identify homogenous subgroups of patients. METHODS: Histologically proven N2-NSCLC patients, who underwent a complete surgical resection were retrospectively reviewed. Clinical and pathological features were reported and analyzed, and survival study was performed. RESULTS: One hundred eighty-three patients were analyzed. Overall 1.3 and 5 years survival rates were, respectively, 70, 35 and 20%, with a median survival time of 24 months. Univariate analysis showed a significant better prognosis for: incidental N2 respect to clinical N2 (5-years 35.4 vs 17.4%); single level lymph node involvement respect to multiple levels (5-years 23.8 vs 14.7%); metastases to superior mediastinal or aortic nodes respect to lower mediastinal nodes (5-years 32 and 24.3 vs 16.3%); right upper lobe tumors with superior mediastinal nodes and left upper lobe tumors with aortic nodes respect to lower lobes tumors with lower mediastinal nodes (5-years 31.8 and 26.9 vs 15.7%). Skip metastases had not a significant survival advantage respect to continuous lymphatic spread. N2 clinical status, the number of levels involved and the two specific patterns of lymphatic spread resulted significant prognostic factors at multivariate analysis. CONCLUSIONS: Clinical N2 status, number of lymph nodes levels involved and specific patterns of lymphatic spread identify homogenous subgroups of patients that can be proposed for different therapeutic strategies. 相似文献
64.
Vito Briganti Lucia Oriolo Vitaliano Buffa Salvatore Garofalo Sebastiano Cavallaro Alessandro Calisti 《European journal of cardio-thoracic surgery》2005,28(1):11-15
OBJECTIVE: A Tracheomalacia complicates 11-33% of cases of Oesophageal Atresia with distal Tracheo-Oesophageal Fistula. The lesion generally involves only the thoracic segment of the trachea, and it has close anatomical relationships with the mediastinal structures, specially with the aortic arch. We therefore tried to define the most important morphotypes of tracheobronchial malacia by using dynamic fiberoptic bronchoscopy (DFB) and spiral multilayer computed tomography (CT). METHODS: Between 1999 and 2003 we studied 40 children from two different institutions who had been operated on at birth for oesophageal atresia. All patients were been submitted to DFB, and the positive cases underwent examination by CT with an iodinated contrast medium. CT angiographic images of great vessels and multiplanar and three-dimensional images of the airways (virtual broncoscopy and broncography) were obtained for morphological evaluation. RESULTS: Twenty-five patients (62%) tested positive for malacia using DBF and all were also confirmed by CT study. In 11 cases (46%), the malacia was located at the thoracic section of the trachea, which was occluded by compression of the aorto-innominate complex. A simple intrinsic tracheomalacia without any vascular compression was present in eight cases (33%), while in five cases (21%), the malacia was complex. CONCLUSIONS: A correct morphological analysis of the malformed segment permitted 'tailored surgery' for each individual patient, allowing us to take account of the type of malacia, its length, and the compressive action exercised by the mediastinal great vessels. 相似文献
65.
Treatment of type B aortic dissection: endoluminal repair or conventional medical therapy? 总被引:4,自引:0,他引:4
Giovanni Dialetto Franco E Covino Giancarlo Scognamiglio Sabrina Manduca Alessandro Della Corte Bruno Giannolo Michelangelo Scardone Maurizio Cotrufo 《European journal of cardio-thoracic surgery》2005,27(5):826-830
OBJECTIVE: To evaluate the mid-term results of endovascular stent-grafting for type B aortic dissection, in comparison with those of standard medical therapy in uncomplicated cases. METHODS: Between January 1999 and 2004, among 56 patients (mean age 59.5+/-11.5 years) with type B aortic dissection, hypotensive medical therapy was the only treatment in 28 uncomplicated cases, (group A), while stent-graft implantation was performed in 28 patients with uncontrolled hypertension, persistent pain or evidence of dissection progression or complication (group B). In 14 cases (50%) the procedure was performed in an acute setting. Stent-grafting procedures were monitored with intraoperative trans-esophageal echocardiography and cine-angiography. CT scan and trans-esophageal echocardiography were performed before hospital discharge, at 6 and 12 months and then yearly. RESULTS: Follow-up (range 1-61 months, average 18.1+/-16.9 months) was 100% complete. In-hospital mortality was 10.7% (three patients, all belonging to Group B; P=0.24). No spinal cord injuries were observed. Early endoleak occurred in one patient (3.5%). Mid-term mortality was lower in Group B, although the difference was not significant (10.7 versus 14.3% in Group A, P=0.71). Follow-up CT scans evidenced complete thrombosis of the false lumen in 75% cases in Group B, 10.7% in Group A (P=0.0001), and an aneurismal dilatation of the descending aorta in 3.5% cases in Group B, 28.5% in Group A (P=0.02). CONCLUSIONS: Although with still considerable early mortality, endovascular stent-graft implantation is an effective option for the treatment of complicated type B aortic dissection. Endovascular treatment achieved a better mid-term fate of the descending thoracic aorta than medical therapy alone, even in patients with worse preoperative conditions. 相似文献
66.
术中射频消融后病灶刮除治疗脊柱转移瘤 总被引:2,自引:1,他引:1
李浩淼 Alessandro Gasbarrini Michele Cappuccio Rakesh Donthineni Lu Boriani Stefano Bandier Laur Foroni Gianandre Pasquinelli Stefano Boriani 《中国脊柱脊髓杂志》2008,18(11)
目的:探讨术中射频消融(RFA)后再行病灶刮除术治疗脊柱转移瘤的可行性及疗效.方法:2004年~2006年,对11例脊柱转移瘤患者术中实施RFA后再行病灶刮除术,将FRA前后病灶标本进行光镜和电镜病理检查,随访患者疼痛缓解情况及肿瘤复发情况.结果:术中未出现脊髓和神经根损伤,RFA后瘤组织固缩,刮除顺利,出血量350~3800ml,平均1024.5ml.全部病例得到6个月以上随访,平均9.8个月,全部患者生存期超过6个月,VAS评分术前平均5.8分,术后6个月时平均1.9分.1例出现局部肿瘤复发.RFA前的标本光、电镜检查均未见肿瘤组织坏死.RFA后光镜检查3例无明显坏死,9例肿瘤细胞完全坏死:电镜检查10例肿瘤细胞完全坏死,1例肿瘤细胞部分坏死,1例无明显坏死.结论:术中RFA后再行病灶刮除治疗脊柱转移瘤安全可行,有利于肿瘤的刮除,减少局部复发的风险. 相似文献
67.
O. Díaz Rizo S. Olivares Reumont J. Viguri Fuente O. Díaz Arado N. López Pino K. D’Alessandro Rodríguez D. de la Rosa Medero A. Gelen Rudnikas G. Arencibia Carballo 《Bulletin of environmental contamination and toxicology》2010,84(1):136-140
Levels of iron, copper, zinc and lead were determined in sediments and soft tissue of the oyster Crassostrea rhizophorae collected from Guacanayabo Gulf, Cuba. Metal-to-Iron ratio in sediments shows an average enrichment for Cu (5,1), Pb (11,7)
and Zn (1,3) in the last 20 years. Metal concentrations found in soft tissue of C. rhizophorae are site dependent. The average biota-sediment accumulation factors (BSAFs) obtained for Fe, Cu and Pb are less than unity
in all cases, indicating that only a little fraction of Cu and Pb in the sediments is bioavailable, independently of their
enrichments. Zinc has an average BSAF value of 2.4 and may represent a serious impact in the area. The concentrations of zinc
and copper in some of the oysters are above typical public health recommended limits. 相似文献
68.
G Sozzi M Miozzo T C Cariani I Bongarzone S Pilotti M A Pierotti G Della Porta 《Cancer Genetics and Cytogenetics》1992,64(1):38-41
We report the cytogenetic analysis of five cases of follicular thyroid adenoma. In two of them, we observed an identical t(2;3)(q12-13;p24-25) as a unique chromosome change. A third case showed a hyperdiploid karyotype with trisomies of chromosomes 7 and 12. Two cases had a normal diploid karyotype. These changes could define subgroups of follicular adenomas endowed with different malignant potential. 相似文献
69.
Giovanni Battista Luciani M.D. Giuseppe Faggian M.D. Alessandro Mazzucco M.D. 《Journal of cardiac surgery》1994,9(2):109-114
We describe a patient with neonatal Marfan syndrome presenting with massive ascending and descending thoracic aortic aneurysm. Because of rapidly progressive respiratory distress due to tracheobronchial compression, emergency replacement of the descending thoracic aorta with a 12-mm PTFE vascular prosthesis was undertaken at 1 month of age. The postoperative course was complicated by bilateral tension pneumothorax contributing to irreversible respiratory failure. The unique clinico-pathological features and the relevant surgical implications of the case are discussed. (J Card Surg 1994;9:109–114) 相似文献
70.
Myocardial protection in adult cardiac surgery: current options and future challenges 总被引:3,自引:0,他引:3
Francesco Nicolini Cesare Beghi Claudio Muscari Andrea Agostinelli Alessandro Maria Budillon Igino Spaggiari Tiziano Gherli 《European journal of cardio-thoracic surgery》2003,24(6):986-993
Current techniques of myocardial protection are evolving with the use of less conventional modalities of cardioplegia and have reduced the morbidity and mortality of cardiac operations. Blood cardioplegic solutions appear superior to cold cardioplegia in terms of myocardial protection and adjuncts as glutamate/aspartate enhancement, antioxidant supplementation, nitric oxide donors and maintenance of calcium homeostasis seem effective. In the near future, further experimental and clinical investigations about pharmacological preconditioning, sodium–hydrogen exchangers inhibition and gene therapy need to be addressed to well define their potential role in the improvement of current techniques of myocardial protection that are suboptimal in high-risk clinical settings. 相似文献