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71.
Marijon E Tivane A Voicu S Vilanculos A Jani D Ferreira B Ou P 《International journal of cardiology》2006,113(3):440-441
A survey conducted by cardiologists in Mozambique provided an opportunity for assessing the prevalence of congenital heart disease in public school children in Maputo. After randomization, a total of 2170 children were examined. Five children had clinical and echographic evidence of congenital heart disease, corresponding to a prevalence of 2.3 in 1000 (95% confidence interval: 1.0 to 5.4), 80% newly discovered during the survey. These findings confirm that congenital heart disease is at least as common in this South African black community as in Caucasians. Early detection of these cardiac diseases in children is important in order to prevent serious complications and to institute endocarditis prevention. 相似文献
72.
Alessandro Antonelli Poupak Fallahi Silvia Martina Ferrari Alda Corrado Marco Sebastiani Dilia Giuggioli Mario Miccoli Anna Linda Zignego Domenico Sansonno Santino Marchi Clodoveo Ferri 《Clinical rheumatology》2013,32(8):1147-1154
The aim was to investigate circulating levels of interelukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α, chemokine (C–X–C motif) ligand (CXCL)10, CXCL11 and chemokine (C–C motif) ligand (CCL)2 in “mixed cryoglobulinemia and hepatitis C” (MC?+?HCV). Serum levels of CXCL11, IL-1β, TNF-α, IL-6, and CCL2 were evaluated in 52 MC?+?HCV vs 52 sex- and age-matched controls to correlate them to the clinical features of mixed cryoglobulinemia. CXCL11 was significantly higher in MC?+?HCV than in controls (264?±?279 vs 70?±?16 pg/mL, respectively; P?=?0.0002; univariate analysis of variance (ANOVA)), in particular in 23 MC?+?HCV with active vasculitis vs those without (293?±?221 vs 168?±?57 pg/mL, respectively; P?<?0.001; ANOVA). Significantly high IL-1β, IL-6, TNF-α, CXCL10, and CCL2 in MC?+?HCV vs healthy controls were confirmed. In a multiple linear regression model (CXCL11 or CCL2, vs age, alanine aminotransferase, IL-1β, IL-6, TNF-α, and CXCL10), CXCL11 was significantly associated with high CXCL10 (P?<?0.001), while CCL2 with high IL-6 (P?<?0.001). This study demonstrates in MC?+?HCV high serum levels of (a) T-helper 1 chemokines, CXCL11 and CXCL10 (related to each other) and (b) proinflammatory cytokines IL-6 and CCL2 (related to each other). 相似文献
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74.
Kojima T Wakamatsu TH Dogru M Ogawa Y Igarashi A Ibrahim OM Inaba T Shimizu T Noda S Obata H Nakamura S Wakamatsu A Shirasawa T Shimazaki J Negishi K Tsubota K 《The American journal of pathology》2012,180(5):1879-1896
An imbalance between free radical generation and radical scavenging antioxidant systems results in oxidative stress, which has been associated with cell injury observed in many age-related diseases. The superoxide dismutase (SOD) family is a major antioxidant system, and deficiency of Cu,Zn-superoxide dismutase-1 (Sod1) in mice leads to many different phenotypes that resemble accelerated aging. In this study we examined the morphologic features and the secretory functions of the lacrimal glands in Sod1(-/-) mice. Lacrimal glands showed atrophy of acinar units; fibrosis; infiltration with CD4(+) T cells, monocytes, and neutrophils; increased staining with both 4-hydroxy-2-nonenal and 8-hydroxy-2'-deoxyguanosine; increases in apoptotic cells; and the presence of the epithelial-mesenchymal transition in senescent Sod1(-/-) mice. Electron microscopy findings revealed evidence of epithelial-mesenchymal transition, presence of swollen and degenerated mitochondria, and the presence of apoptotic cell death in the lacrimal glands of senescent Sod1(-/-) mice. These alterations were also associated with the accumulation of secretory vesicles in acinar epithelial cells, decreased production of both stimulated and nonstimulated tears, and a decline in total protein secretion from the lacrimal glands. Our results suggest that Sod1(-/-) mice may be a good model system in which to study the mechanism of reactive oxygen species-mediated lacrimal gland alterations. 相似文献
75.
Bauer M Glenn T Alda M Andreassen OA Ardau R Bellivier F Berk M Bjella TD Bossini L Del Zompo M Dodd S Fagiolini A Frye MA Gonzalez-Pinto A Henry C Kapczinski F Kliwicki S König B Kunz M Lafer B Lopez-Jaramillo C Manchia M Marsh W Martinez-Cengotitabengoa M Melle I Morken G Munoz R Nery FG O'Donovan C Pfennig A Quiroz D Rasgon N Reif A Rybakowski J Sagduyu K Simhandl C Torrent C Vieta E Zetin M Whybrow PC 《Bipolar disorders》2012,14(6):654-663
Bauer M, Glenn T, Alda M, Andreassen OA, Ardau R, Bellivier F, Berk M, Bjella TD, Bossini L, Del Zompo M, Dodd S, Fagiolini A, Frye MA, Gonzalez‐Pinto A, Henry C, Kapczinski F, Kliwicki S, König B, Kunz M, Lafer B, Lopez‐Jaramillo C, Manchia M, Marsh W, Martinez‐Cengotitabengoa M, Melle I, Morken G, Munoz R, Nery FG, O’Donovan C, Pfennig A, Quiroz D, Rasgon N, Reif A, Rybakowski J, Sagduyu K, Simhandl C, Torrent C, Vieta E, Zetin M, Whybrow PC. Impact of sunlight on the age of onset of bipolar disorder. Bipolar Disord 2012: 14: 654–663. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S. Objective: Although bipolar disorder has high heritability, the onset occurs during several decades of life, suggesting that social and environmental factors may have considerable influence on disease onset. This study examined the association between the age of onset and sunlight at the location of onset. Method: Data were obtained from 2414 patients with a diagnosis of bipolar I disorder, according to DSM‐IV criteria. Data were collected at 24 sites in 13 countries spanning latitudes 6.3 to 63.4 degrees from the equator, including data from both hemispheres. The age of onset and location of onset were obtained retrospectively, from patient records and/or direct interviews. Solar insolation data, or the amount of electromagnetic energy striking the surface of the earth, were obtained from the NASA Surface Meteorology and Solar Energy (SSE) database for each location of onset. Results: The larger the maximum monthly increase in solar insolation at the location of onset, the younger the age of onset (coefficient= ?4.724, 95% CI: ?8.124 to ?1.323, p = 0.006), controlling for each country’s median age. The maximum monthly increase in solar insolation occurred in springtime. No relationships were found between the age of onset and latitude, yearly total solar insolation, and the maximum monthly decrease in solar insolation. The largest maximum monthly increases in solar insolation occurred in diverse environments, including Norway, arid areas in California, and Chile. Conclusion: The large maximum monthly increase in sunlight in springtime may have an important influence on the onset of bipolar disorder. 相似文献
76.
A. Nunes R. Ardau A. Berghöfer A. Bocchetta C. Chillotti V. Deiana J. Garnham E. Grof T. Hajek M. Manchia B. Müller-Oerlinghausen M. Pinna C. Pisanu C. O’Donovan G. Severino C. Slaney A. Suwalska P. Zvolsky P. Cervantes M. del Zompo P. Grof J. Rybakowski L. Tondo T. Trappenberg M. Alda 《Acta psychiatrica Scandinavica》2020,141(2):131-141
77.
78.
Relational job characteristics and well‐being: A study among Portuguese and Brazilian hospital nurses
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Alda Santos Filipa Castanheira Maria José Chambel Michael Vieira Amarante Carlos Costa 《Stress and health》2017,33(4):415-425
Nurse well‐being is a crucial factor in the quality of care given to patients and in patient safety. The purpose of this study was to investigate the relationships between the psychological effects of relational job characteristics (PERJCs) and indicators of well‐being in hospital nurses. The data for this correlational study were collected from an online survey responded to by a sample of 620 hospital nurses (335 Portuguese and 285 Brazilian). Statistical procedures included structural equation modeling and multigroup analysis. A full mediation model was supported by data analysis, in which work‐related well‐being (i.e., engagement and burnout) explained the relationships between hospital nurses' perceived social worth and their context‐free well‐being. Moreover, in the Portuguese sample, the perceived social impact on client lives and the affective commitment to clients were indirectly related to the context‐free well‐being of nurses, through work engagement. Practical implications are presented in order to foster the PERJCs, thus contributing to nurse well‐being. 相似文献
79.
Alda Saldan Gabriella Forner Carlo Mengoli Daniel Tinto Loredana Fallico Marta Peracchi Nadia Gussetti Giorgio Palù Davide Abate 《Journal of clinical microbiology》2016,54(5):1352-1356
Human cytomegalovirus (CMV) infection is a major cause of congenital infection leading to birth defects and sensorineural anomalies, including deafness. Recently, cell-mediated immunity (CMI) in pregnant women has been shown to correlate with congenital CMV transmission. In this study, two interferon gamma release assays (IGRA), the CMV enzyme-linked immunosorbent spot (ELISPOT) and CMV QuantiFERON assays, detecting CMV-specific CMI were compared. These assays were performed for 80 CMV-infected (57 primarily and 23 nonprimarily) pregnant women and 115 controls, including 89 healthy CMV-seropositive pregnant women without active CMV infection, 15 CMV-seronegative pregnant women, and 11 seropositive or seronegative nonpregnant women. Statistical tests, including frequency distribution analysis, nonparametric Kruskal-Wallis equality-of-populations rank test, Wilcoxon rank sum test for equality on unmatched data, and lowess smoothing local regression, were employed to determine statistical differences between groups and correlation between the assays. The CMV ELISPOT and CMV QuantiFERON assay data were not normally distributed and did not display equal variance. The CMV ELISPOT but not CMV QuantiFERON assay displayed significant higher values for primarily CMV-infected women than for the healthy seropositive pregnant and nonpregnant groups (P = 0.0057 and 0.0379, respectively) and those with nonprimary infections (P = 0.0104). The lowess local regression model comparing the assays on an individual basis showed a value bandwidth of 0.8. Both assays were highly accurate in discriminating CMV-seronegative pregnant women. The CMV ELISPOT assay was more effective than CMV-QuantiFERON in differentiating primary from the nonprimary infections. A substantial degree of variability exists between CMV ELISPOT and CMV QuantiFERON assay results for CMV-seropositive pregnant women. 相似文献
80.
Alda Pereira da Silva A. Valente Â. Gil I. Alonso R. Ribeiro M. Bicho J. Gorjão-Clara 《The journal of nutrition, health & aging》2016,20(3):256-266